NOXA1
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Official Full Name
NADPH oxidase activator 1
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Overview
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive;oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3;domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the;tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NOXA1; NADPH oxidase activator 1; SDCCAG31, serologically defined colon cancer antigen 31; FLJ25475; NY CO 31; MGC131800; SDCCAG31; Antigen NY CO 31; Antigen NY-CO-31; Inhibitory NADPH oxidase activator 1; NCF2 like protein; NCF2-like protein; NOX activator 1; NOXA 1; NOXA1_HUMAN; p51 nox; p51-nox; p51NOX; P67phox like factor; P67phox-like factor; Serologically defined colon cancer antigen 31; NY-CO-31;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
NOXA1 involved in several pathways and played different roles in them. We selected most pathways NOXA1 participated on our site, such as Integrated Breast Cancer Pathway, Integrated Cancer pathway, Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOXA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Integrated Breast Cancer Pathway | UBE2F;CYP19A1;USP38;GDI1;MYT1;PLK3;CCNB1IP1;EDAR;SMARCA4 |
| Integrated Cancer pathway | |
| Integrated Pancreatic Cancer Pathway | CASP12;MAPK4;FKBP1B;TFF1;RAPGEF3;AGA;FST;CST3;IL11 |
| Prostate Cancer | PIK3R1;PDPK1;PIK3CB;ARID1A;MAP2K1;CASP9;CREB3L2;INS2;PDGFRA |
| RAC1 signaling pathway | IQGAP3;RACGAP1;NOXO1;BAIAP2;ABI1;ABI2;NOXA1;NCKAP1 |
| RHO GTPase Effectors | DIAPH1;ABI2;SKA2;ZW10;RHPN2;NOXO1;NCKAP1;EVL;CIT |
| RHO GTPases Activate NADPH Oxidases | NOXO1;NOXO1A;NOXA1 |
| Signal Transduction | SOX13;TAC3;DACT1;PDK2;METAP2B;RPGRIP1L;PPEF1;ASH2L;AMOTL2B |
NOXA1 has several biochemical functions, for example, Rac GTPase binding, SH3 domain binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOXA1 itself. We selected most functions NOXA1 had, and list some proteins which have the same functions with NOXA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rac GTPase binding | CORO1C;PAK2A;NOXA1;RALBP1;PAK1;RCC2;PAK2B;ARHGEF2;SRGAP1 |
| SH3 domain binding | SGIP1;ADAM19;SHANK3;CASP9;FAM125A;ILK;INPPL1;ABI2;DNAJC6 |
| enzyme binding | MTA1;A2M;MAPK8;TNKS2;CDC20;CAT;GSTM4;CRB2;TGFB1 |
| protein binding | PTPN9;TRAIP;CHMP1B;SCARB2;KRT17;SMU1;TRIM10;ZC3HC1;UBE2E2 |
| superoxide-generating NADPH oxidase activator activity | PDGFB;NOXA1;NOXO1;NCF4;AGT |
NOXA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOXA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOXA1.
NOXO1; RIMBP3; Dlg4; RHOU; CACNA1A; PRKCG; EP300; ugpB3; YWHAZ
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