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NPAS4

  • Official Full Name

    neuronal PAS domain protein 4

  • Overview

    NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS);class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe;et al., 2004 (PubMed 14701734)).
  • Synonyms

    NPAS4; neuronal PAS domain protein 4; neuronal PAS domain-containing protein 4; bHLHe79; Le PAS; limbic enhanced PAS protein; PASD10; bHLH PAS type transcription factor NXF; Class E basic helix-loop-helix protein 79; HLH-PAS transcription factor NXF; Neuronal PAS4; NPAS4_HUMAN; NXF; PAS domain-containing protein 10; limbic-enhanced PAS protein; bHLH-PAS type transcription factor NXF; LE-PAS;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NPAS4-6017H Recombinant Human NPAS4 Protein, GST-tagged Wheat Germ GST
Human NPAS4-6608HF Recombinant Full Length Human NPAS4 Protein, GST-tagged In Vitro Cell Free System GST 802 amino acids
Mouse NPAS4-10805M Recombinant Mouse NPAS4 Protein Mammalian Cell His
Mouse NPAS4-6150M Recombinant Mouse NPAS4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NPAS4-6150M-B Recombinant Mouse NPAS4 Protein Pre-coupled Magnetic Beads HEK293
Rat NPAS4-4036R Recombinant Rat NPAS4 Protein Mammalian Cell His
Rat NPAS4-3695R Recombinant Rat NPAS4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NPAS4-3695R-B Recombinant Rat NPAS4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NPAS4 Related Articles

NPAS4 involved in several pathways and played different roles in them. We selected most pathways NPAS4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NPAS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

NPAS4 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPAS4 itself. We selected most functions NPAS4 had, and list some proteins which have the same functions with NPAS4. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZSCAN4C;SRFB;EOMES;FOXO3;C19orf40;NKX2-3;EGR3;HLTF;LIN28B
RNA polymerase II core promoter proximal region sequence-specific DNA bindingSIX2;TTC6;ZFP746;ESRRA;ZNF543;MIXL1;ETV4;ZNF395;E2F4
RNA polymerase II regulatory region DNA bindingTXK;ATXN3L;NCOA1;NKX2-1;NPAS4;PPARG
RNA polymerase II transcription factor activity, sequence-specific DNA bindingETV5B;PLAGL1;FOXO1B;HIF1AL2;SOX8B;PAX6B;FOXQ2;TP53;OVOL1
protein dimerization activityMESPBB;USF1L;HER1;ZBED4;ATOH1A;ABCG1;MYO5A;MYC;HES7
protein heterodimerization activityPOLA1;TAF6;ADORA1;Itgam&Itgb2;WHRN;EFHA1;POLE4;RARA;NFE2L2A
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGATA1;NR6A1;NEUROD1;NR1H4;PATZ1;TRP63;ESR1;ONECUT1;SIX4

NPAS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPAS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPAS4.

Jaehne, EJ; Klaric, TS; et al. Effects of Npas4 deficiency on anxiety, depression-like, cognition and sociability behaviour. BEHAVIOURAL BRAIN RESEARCH 281:276-282(2015).
Wang, D; Ren, M; et al. The Inhibitory Effects of Npas4 on Seizures in Pilocarpine-Induced Epileptic Rats. PLOS ONE 9:-(2014).
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