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NPHP4

Official Full Name

nephronophthisis 4
Overview

This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa.
Synonyms

NPHP4; nephronophthisis 4; nephrocystin-4; KIAA0673; nephrocystin 4; nephroretinin; POC10; POC10 centriolar protein homolog (Chlamydomonas); SLSN4; NPHP4_HUMAN; POC10 centriolar protein homolog;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

C
His
GST
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NPHP4-6029H	Recombinant Human NPHP4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	NPHP4-6622HF	Recombinant Full Length Human NPHP4 Protein, GST-tagged	In Vitro Cell Free System	GST	81 amino acids	Inquiry
Mouse	NPHP4-10821M	Recombinant Mouse NPHP4 Protein	Mammalian Cell	His		Inquiry
Mouse	Nphp4-6758M	Recombinant Mouse Nphp4 Protein (Met1-Gly478), C-His tagged	E.coli	C-His	Met1-Gly478	Inquiry
Mouse	NPHP4-6159M-B	Recombinant Mouse NPHP4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	NPHP4-6159M	Recombinant Mouse NPHP4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Nphp4-6759M	Recombinant Mouse Nphp4 Protein (Gly760-Gln1425), C-His tagged	E.coli	C-His	Gly760-Gln1425	Inquiry

Involved Pathway
Protein Function
Interacting Protein

NPHP4 involved in several pathways and played different roles in them. We selected most pathways NPHP4 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPHP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Anchoring of the basal body to the plasma membrane	MARK4;FBF1;CEP135;CSNK1D;CEP89;CCP110;DCTN2;ODF2B;DYNC1I2
Assembly of the primary cilium	NEK2;TRAF3IP1;TTBK2;DYNLRB2;TCTN1;NEDD1;HSPB11;HDAC6;CENPJ
Organelle biogenesis and maintenance	LZTFL1;B9D1;GABPA;MKS1;MRPL52;UNC119.1;IFT80;TTC21B;TFB2M
Signal Transduction	OMG;FSTL1B;TAGAP1;METAP2;CDC73;ADH8B;SKIA;PTPRU;GAS8
Signaling by Hippo	MOB1BA;AMOTL2A;TJP2B;NPHP4;AMOTL2;AMOTL2B

NPHP4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPHP4 itself. We selected most functions NPHP4 had, and list some proteins which have the same functions with NPHP4. You can find most of the proteins on our site.

Function	Related Protein
protein binding	DNAAF2;SUFU;ERO1L;TCEA2;SLC1A2;MYCN;RPL19;NSF;ATP2B1

NPHP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPHP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPHP4.

Nphp1; Rpgrip1l; Iqcb1; Nphp1; a2bfa6_mouse; Calu