NPR1
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Official Full Name
natriuretic peptide receptor 1
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Overview
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009] -
Synonyms
NPR1; natriuretic peptide receptor 1; ANPa; NPRA; ANPRA; GUC2A; GUCY2A; atrial natriuretic peptide receptor 1; GC-A; ANP-A; NPR-A; ANPR-A; guanylate cyclase A; natriuretic peptide receptor A; atrionatriuretic peptide receptor A; natriuretic peptide A type receptor; atrial natriuretic peptide receptor type A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A);
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- Involved Pathway
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- Interacting Protein
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NPR1 involved in several pathways and played different roles in them. We selected most pathways NPR1 participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | ADSSL;ADA;ADSSL1;NT5C1A;XDH;ENTPD8;NME1-NME2;IMPDH2;PRIM1 |
| cGMP-PKG signaling pathway | PLCB4;KCNMB4;ATP1B4;MYH7;INS1;PDE5A;ROCK2;BNP;PIK3CB |
| cAMP signaling pathway | MC2R;FXYD1;PIK3R1;PLN;LIPE;ATP2A2;HCAR3;MAPK10;MLLT4 |
| Vascular smooth muscle contraction | RHOAA;RAF1;CACNA1D;ADCY2B;EDNRAA;PRKCD;NPR1;PLA2G2E;PRKCH |
| Oxytocin signaling pathway | PIK3CD;MYL6B;PRKACB;RCAN1;MAP2K1;ITPR3;PIK3R5;FOS;PRKAG3 |
| Regulation of lipolysis in adipocytes | PDE3B;NPY;GNAI3;NPR1;NPY1R;PLIN1;IRS2;PTGS1;PRKG1 |
| Renin secretion | ORAI1;PPP3R2;PRKACB;REN;GNAI2;GNAS;LOC100328615;CLCA3;AGTR1A |
| Aldosterone synthesis and secretion | ADCY7;SLC14A2;CREB3;PLCB2;NETO2;CAMK4;CAMK2B;PRKACB;CAMK2D |
NPR1 has several biochemical functions, for example, ATP binding, G-protein coupled peptide receptor activity, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPR1 itself. We selected most functions NPR1 had, and list some proteins which have the same functions with NPR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NEK4;FLAD1;NTRK3;MAPK6;EPHA7;MTHFS;PARS2;MAPKAPK5;FGFR2 |
| G-protein coupled peptide receptor activity | NPR3;FSHR;NPR1;GPR37;TSHR;RXFP4;MCHR2;CYSLTR1;MC1R |
| GTP binding | RAB18;CDC42L2;CDC42;ATL1;GTPBP5;GUCY1A3;DIRAS3;RAB7L1;ARL17B |
| NOT adenylate cyclase activity | GUCY2C;GUCY1A3;NPR1;NPR2;GUCY1B3;GC2;NPR1A;GC3;NPR3 |
| guanylate cyclase activity | GUCY1B3;NPR1A;NPR2;GUCY2C;GC3;GUCY2E;GUCY2F;NPR1;GUCY1A3 |
| hormone binding | LRP2;TTR;MC5R;GPR30;MTNR1A;CRYM;NPR1;ADIPOR1A;NPR2 |
| natriuretic peptide receptor activity | NPR3;NPR2;NPR1;NPR1A |
| peptide hormone binding | CRHR2;RXFP2;PTH1RA;OXTR;MAS1;NPR2;HCRTR2;GHSR;NPR3 |
| protein kinase activity | CHUK;EK1;CDK9;PKN1;TNIKA;EIF2AK3;JAK2;MAP2K5;AKT1 |
| protein kinase binding | SKAP1;GATA4;SPRED1;PARK2;TENC1;MAPK8IP2;PDGFRB;CCNL1B;TRIB3 |
NPR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPR1.
Ndc80; ATF7IP; MYC
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