npy1r
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  • Official Full Name
  • neuropeptide Y receptor Y1
  • Background
  • Neuropeptide Y (NPY; MIM 162640) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits;a diverse range of important physiologic activities, including effects on psychomotor activity, food intake,;regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major;subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors, such as NPY1R, have been;identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic;smooth muscle (Herzog et al., 1992 (PubMed 1321422)).
  • Synonyms
  • NPY1R; neuropeptide Y receptor Y1; NPYR; neuropeptide Y receptor type 1; NPY1-R
Cat.#:NPY1R-1351HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPY1R, GST-tagged
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Cat.#:NPY1R-10846MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NPY1R Protein
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Cat.#:NPY1R-3087RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NPY1R Protein, His-tagged
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Cat.#:NPY1R-3179CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NPY1R
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Cat.#:NPY1R-5917ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NPY1R
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Cat.#:NPY1R-1214HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NPY1R cell lysate
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Cat.#:Kit-1443Tag:
Source (Host):Species:
Product nameNPY1R CHO-K1 β-Arrestin GPCR Assay Kit
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Cat.#:Kit-0957Tag:
Source (Host):Species:
Product nameTR-FRET Progesterone Receptor Coactivator Assay Kit
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Cat.#:CSC-RG0331Tag:
Source (Host):Species:Human
Product nameHuman NPY1R-FLAG Stable Cell Line-CHO-K1 Galphaqi5
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Cat.#:CSC-RG0575Tag:
Source (Host):Species:Human
Product nameHuman NPY1R/Gi/Go Stable Cell Line-CHO
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Cat.#:CSC-RG0899Tag:
Source (Host):Species:Human
Product nameHuman NPY1R Stable Cell Line-HEK293-CNG
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Involved Pathway

NPY1R involved in several pathways and played different roles in them. We selected most pathways NPY1R participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPY1R were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
CNGA4; HHIP; CREB5; PRKACB; GIPR; MAPK1; HCAR2; PIK3CD; NFATC1; RAP1B
Neuroactive ligand-receptor interaction
CHRNB3A; TRHR; GRIN2BB; LPAR2; HTR5A; F2RL1.1; P2RY14; MTNR1A; Chrng; OPRD1A
Regulation of lipolysis in adipocytes
FABP4; PIK3CD; PIK3CA; AKT2; IRS4; PTGER3; IRS2; PRKACG; Adcy4; GNAI3

Protein Function

NPY1R has several biochemical functions, for example, neuropeptide Y receptor activity, pancreatic polypeptide receptor activity, peptide YY receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NPY1R itself. We selected most functions NPY1R had, and list some proteins which have the same functions with NPY1R. You can find most of the proteins on our site.
Function
Related Protein
Function neuropeptide Y receptor activity
Related Protein NPY1R; PROKR2; NPY5R; NPY8BR; PRLH2R; PRLHR2B; QRFPR; NPY2R; NPY8AR; PROKR1
Function pancreatic polypeptide receptor activity
Related Protein PPYR1; NPY8BR; NPY5R; NPY1R; NPY8AR
Function peptide YY receptor activity
Related Protein NPY1R; NPY2R; PPYR1; NPY5R
Function protein binding
Related Protein WNT3; BLK; PPARG; FAM92A; P2RX4; TAP1; HSPA14; ANKRD24; CDK13; ALOX12B

Interacting Protein

NPY1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPY1R here. Most of them are supplied by our site. Hope this information will be useful for your research of NPY1R.
GALR2; NPY; PYY; ATP13A2; LSM7

NPY1R Related Articles

Xiang, Q; Wang, CL; et al. Interaction of Somatostatin receptor-2 and Neuropeptide Y receptor-1 in mice dorsal root ganglion neurons on the Pinch-nerve injury model (Retracted article. See vol. 110, pg. 273, 2013). PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 105:71-75(2013).
Singh, S; Metz, I; et al. Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons. ACTA NEUROPATHOLOGICA 125:595-608(2013).