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NR0B1

Official Full Name

nuclear receptor subfamily 0, group B, member 1
Overview

This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
Synonyms

NR0B1; nuclear receptor subfamily 0, group B, member 1; AHC, dosage sensitive sex reversal , DSS; nuclear receptor subfamily 0 group B member 1; AHCH; DAX1; nuclear receptor DAX1; nuclear receptor DAX-1; nuclear hormone receptor; DSS-AHC critical region;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
Myc
DDK
MYC
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NR0B1-11833H	Recombinant Human NR0B1, His-tagged	E.coli	His	202-380a.a.	$319 / 25ug
Human	NR0B1-3723HCL	Recombinant Human NR0B1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NR0B1-6064H	Recombinant Human NR0B1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	NR0B1-2810H	Recombinant Human NR0B1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	NR0B1-6687HF	Recombinant Full Length Human NR0B1 Protein, GST-tagged	In Vitro Cell Free System	GST	470 amino acids	Inquiry
Mouse	Nr0b1-1094M	Recombinant Mouse Nr0b1 protein, His & T7-tagged	E.coli	His/T7	Met1~Ala227 (Accession # Q61066)	Inquiry
Mouse	Nr0b1-556M	Recombinant Mouse Nr0b1 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Rat	Nr0b1-1095R	Recombinant Rat Nr0b1 protein, His & T7-tagged	E.coli	His/T7	Met1~Ala227 (Accession # P70503)	Inquiry
Rat	NR0B1-4060R	Recombinant Rat NR0B1 Protein	Mammalian Cell	His		Inquiry
Rat	NR0B1-3719R	Recombinant Rat NR0B1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NR0B1-3719R-B	Recombinant Rat NR0B1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	NR0B1-3091R	Recombinant Rhesus monkey NR0B1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	NR0B1-2910R	Recombinant Rhesus Macaque NR0B1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	NR0B1-2910R-B	Recombinant Rhesus Macaque NR0B1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	NR0B1-5308Z	Recombinant Zebrafish NR0B1	Mammalian Cell	His		Inquiry
Chicken	NR0B1-6162C	Recombinant Chicken NR0B1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

NR0B1 involved in several pathways and played different roles in them. We selected most pathways NR0B1 participated on our site, such as Gene Expression, Generic Transcription Pathway, Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR0B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gene Expression	SUGP1;ZNF324;KHSRP;ZNF544;HIPK1;YAP1;EIF3K;SETB;METTL1
Generic Transcription Pathway	ZNF597;ZNF498;ZNF547;ZNF697;ZNF354B;ZNF556;RRAGA;COX8A;ZNF230
Nuclear Receptor transcription pathway	VDRB;RARGA;NR2F6;NR2E1;NR2F1A;NR1D2B;NRBP1;NR4A2B;NR1I2
Nuclear Receptors	NR0B1;NR1D2B;RORAA;NR2E1;VDRB;RARGB;NR2F6;NR2F2;ROR1
Regulation of Androgen receptor activity	SMARCA2;NR0B1;NR2C2;KAT7;SPDEF;SMARCE1;GATA2;HOXB13;NR2C1

NR0B1 has several biochemical functions, for example, AF-2 domain binding, DNA binding, DNA hairpin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR0B1 itself. We selected most functions NR0B1 had, and list some proteins which have the same functions with NR0B1. You can find most of the proteins on our site.

Function	Related Protein
AF-2 domain binding	NR0B1;ESRRG;PPARGC1B
DNA binding	PTF1A;EBF4;STAT5B;C1D;HIST1H2AD;SETBP1;ZNF83;PGR;TAF1A
DNA hairpin binding
RNA binding	DDX19A;PAPOLB;RNMT;KIAA0430;ZFP346;DAZL;ADAD2;RAVER1;SNRPF
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	NR2F2;ESRRA;NR4A2A;NR2F6B;NR1D2;STAT3;RORC;PPARD;NR5A1
protein binding	RIPPLY2;PLEKHG4;SKP2;MTF1;CCDC103;SHD;TTC12;CYBA;ELMOD3
protein domain specific binding	HIST1H4C;HAND2;GNAI3;DDX20;CALM3;GABRR3;ETV6;MTOR;XPA
protein homodimerization activity	RAB11FIP3;CCDC88A;STK10;TPD52L1;MAP3K10;ABCG1;ODZ4;PDCD6IP;TCF4
sequence-specific DNA binding	ZNF35;ZGPAT;RORAB;ESRRA;OTP;DLX4;LHX8;LHX2A;HLF
steroid hormone receptor activity	NR2F6B;NR6A1;NR2C1;HNF4A;OLFR78;RORC;NR2F1A;VDR;RARG
steroid hormone receptor binding
transcription corepressor activity	TBL1Y;PSMC3;PFDN5;JAZF1;CDYL;SSX4;NAB2;SKI;BASP1
transcription factor binding	PAX2;HHEX;DACT2;RNF19A;SMARCA4;TRIB2;ATOH8;PBX1;RBL1

NR0B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR0B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR0B1.

ESRRG; NR5A1; RORA