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NRP2

  • Official Full Name

    neuropilin 2

  • Overview

    Vascular Endothelial Growth Factor (VEGF) is a potent mitogen for vascular endothelial cells. It significantly influences vascular permeability and is a strong angiogenic protein. VEGF probably also plays a role in neovasularization under physiological conditions. A potent synergism between VEGF and bFGF in the induction of angiogenesis has been observed. Due to its influences on vascular permeability, VEGF may be involved in altering blood-brain-barrier functions under normal and pathological conditions.
  • Synonyms

    NRP2; neuropilin 2; neuropilin-2; VEGF165R2; neuropilin-2b(0); neuropilin-2a(17); neuropilin-2a(22); receptor for VEGF165 and semaphorins class3; vascular endothelial cell growth factor 165 receptor 2; NP2; NPN2; PRO2714; MGC126574;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • hFc
  • His
  • Fc
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NRP2-1047H Recombinant Human NRP2 protein(Met1-Tyr855), hFc-tagged HEK293 C-hFc Met1-Tyr855
Human NRP2-273H Recombinant Human NRP2, Fc tagged Human Cell His
Human NRP2-8250H Recombinant Human NRP2 protein, His & T7-tagged E.coli His/T7 Gly231~Val490 (Accession # O60462)
Human NRP2-818H Recombinant Human NRP2, His tagged Human Cell His
Human NRP2-937HCL Recombinant Human NRP2 cell lysate Human Cell N/A
Human NRP2-1241H Recombinant Human NRP2 protein, His-tagged HEK293 His Met1-Tyr855
Human NRP2-4970H Recombinant Human NRP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NRP2-0517H Active Recombinant Human NRP2 protein, His-tagged HEK293 His Arg21-Pro864
Human NRP2-5253H Recombinant Human NRP2 Protein (Gly231-Val490), N-His tagged E.coli N-His Gly231-Val490
Mouse Nrp2-956M Active Recombinant Mouse Nrp2 Protein, Fc Chimera Mammalian cells Fc
Mouse NRP2-10899M Active Recombinant Mouse Nrp2 protein, Fc-tagged Mammalian cells Fc
Mouse Nrp2-4503M Recombinant Mouse Nrp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NRP2-508M Active Recombinant Mouse NRP2 protein(Met1-Pro864), His-tagged HEK293 C-His Met1-Pro864
Mouse Nrp2-94M Recombinant Mouse Nrp2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Nrp2-94M-B Recombinant Mouse Nrp2 Protein Pre-coupled Magnetic Beads HEK293
Rat Nrp2-492R Active Recombinant Rat Neuropilin 2, His-tagged Mammalian cells His
Rat Nrp2-954R Active Recombinant Rat Nrp2 Protein, Fc Chimera Mammalian cells Fc
Rat NRP2-4085R Recombinant Rat NRP2 Protein Mammalian Cell His
Rat Nrp2-8251R Recombinant Rat Nrp2 protein, His & GST-tagged E.coli His/GST Glu652~Pro858
Rat Nrp2-1863R Recombinant Rat Nrp2 Protein, His-tagged E.coli N-His Glu652-Pro858
Rat Nrp2-15R-B Recombinant Rat Nrp2 Protein Pre-coupled Magnetic Beads HEK293
Rat Nrp2-15R Recombinant Rat Nrp2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken NRP2-5857C Recombinant Chicken NRP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NRP2 Related Articles
  • NRP2 Related Research Area

NRP2 involved in several pathways and played different roles in them. We selected most pathways NRP2 participated on our site, such as Axon guidance, Developmental Biology, L1CAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceGSK3B;SEMA3B;GFRA2;PTK2;KIF4;TRPC4;NRP2;PAQR3A;SIAH2
Developmental BiologyDPYSL2;MED6;PRDM14;INSM1B;DUSP6;EPHA2A;CDON;CRMP1;NKX2.2A
L1CAM interactionsDPYSL2;KCNQ2;NRP1A;DCX;SCN8A;RANBP9;DLG3;SCN3A;KCNQ3
Neurophilin interactions with VEGF and VEGFRNRP2;NRP1A;NRP2A;NRP2B
NrCAM interactions
Signal TransductionGPR37L1;STRA6;PYGO2;RGS9BP;ANXA1A;GPR18;GPR132B;RGS6;SCT
Signaling by VEGFSHB;JUPA;NRP2A;NRP2;DSCAMA;NRP2B;AXL
Signaling events mediated by VEGFR1 and VEGFR2

NRP2 has several biochemical functions, for example, cytokine binding, growth factor binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRP2 itself. We selected most functions NRP2 had, and list some proteins which have the same functions with NRP2. You can find most of the proteins on our site.

Function Related Protein
cytokine bindingKIT;Fzd4;ELANE;NRP1;NOG;IL31RA;CHRD;IFNGR1;LIFR
growth factor bindingLTBP4;NRP2;NKD2;BMPR2;FGFBP2;RHBDF2;TEK;RHBDF1;FLT1
heparin bindingADAMTSL5;APLP2;VEGFAB;ADAMTS1;SERPINA10;FGF12;UBE4A;CTGFA;EPYC
metal ion bindingTNNI1;ZNF83;ZNF124;TTC4;GART;TRIM55B;ZFPM2A;MARCH6;ZFP879
receptor activityCALCR;PVR;TIGIT;NLGN3B;Tnfrsf22;GRIA4A;ANPEP;TACSTD2;LILRB2
semaphorin receptor activityNRP1;PLXNC1;PLXNB2A;NRP1A;PLXNA1B;NRP2B;NRP1B;NRP2A;PLXND1
vascular endothelial growth factor-activated receptor activityFLT4;NRP1A;NRP1B;PDGFRA;NRP2;NRP2A;FLT1;NRP2B;NRP1

NRP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRP2.

Gogineni, A; Caunt, M; et al. Inhibition of VEGF-C Modulates Distal Lymphatic Remodeling and Secondary Metastasis. PLOS ONE 8:-(2013).
Susarla, R; Gonzalez, AM; et al. Expression of receptors for VEGFs on normal human thyroid follicular cells and their role in follicle formation. JOURNAL OF CELLULAR PHYSIOLOGY 227:1992-2002(2012).
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