NTHL1
-
Official Full Name
nth endonuclease III-like 1 (E. coli)
-
Overview
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. -
Synonyms
NTHL1; nth endonuclease III-like 1 (E. coli); nth (E.coli endonuclease III) like 1; endonuclease III-like protein 1; NTH1; OCTS3; Endonuclease III like protein 1; NTH 1; NTH endonuclease III Like 1; NTHL 1; NTHL1_HUMAN; OCTS 3; OTTHUMP00000158939;
- Recombinant Proteins
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- Myc
- DDK
- Myc|DDK
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | NTHL1-20H | Recombinant Human NTHL1 protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
|
|
| Human | NTHL1-2488H | Recombinant Human Nth Endonuclease III-Like 1 (E. coli), His-tagged | E.coli | His | 1-312aa |
|
| Human | NTHL1-107H | Recombinant Human NTHL1 Protein, His-tagged | E.coli | His |
|
|
| Human | NTHL1-1982H | Recombinant Human NTHL1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
|
|
| Mouse | Nthl1-4519M | Recombinant Mouse Nthl1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
|
|
| Chicken | NTHL1-3545C | Recombinant Chicken NTHL1 | Mammalian Cell | His |
|
- Involved Pathway
- Protein Function
- Interacting Protein
- NTHL1 Related Articles
- NTHL1 Related Research Area
NTHL1 involved in several pathways and played different roles in them. We selected most pathways NTHL1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | XRCC1;OGG1;LIG3;MPG;POLB;NEIL3;PARP4;MUTYH;PARP2 |
NTHL1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, DNA N-glycosylase activity, DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NTHL1 itself. We selected most functions NTHL1 had, and list some proteins which have the same functions with NTHL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 4 iron, 4 sulfur cluster binding | LIAS;ISCA1;POLE;CDKAL1;RSAD1;TYW1;ACO1;NDUFS7;DPYDB |
| DNA N-glycosylase activity | NEIL3;NEIL1;TDG;SMUG1;OGG1;NTHL1 |
| DNA-(apurinic or apyrimidinic site) lyase activity | APEX2;HMGA2;HMGA1B;APEX1;NEIL3;HMGA1A;HMGA1;NTHL1;NEIL1 |
| double-stranded DNA binding | SAFB;RAD51C;HLF;TDG;DMC1;DDX58;CTNNB1;TRP63;USF1 |
| endonuclease activity | DROSHA;EAR14;DCLRE1C;RNASE3;PMS2;RNASEL2;OGG1;DNASE2A;ENDOU2 |
| metal ion binding | PDE6B;KDM3B;TRIM43B;PRKCDA;TRIM35-19;CYP2K17;LOC780933;TIMM10B;ANKFY1 |
| oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | SMUG1;NTHL1 |
| protein binding | NCDN;EIF2S1;ZFAND2B;HRK;IMPA1;ATP6V0C;KRTAP4-2;ARNTL1A;SYT2 |
NTHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTHL1.
GAPDHS; MYH7; RBL1; NUDT1; RNMTL1; RPL10; Rpl35; CAMKK1; Gspt1
- Q&As
- Reviews
Q&As (5)
Ask a questionIndividuals with NTHL1 mutations may benefit from genetic counseling to understand their cancer risks and make informed decisions about their healthcare.
Yes, individuals with NTHL1 mutations may have an increased risk of developing certain types of cancer, making it a potential biomarker for cancer risk assessment.
NTHL1 protein is involved in the base excision repair pathway, where it removes damaged DNA bases and initiates the repair process.
NTHL1 mutations can be inherited in an autosomal recessive manner, meaning that both parents need to carry a mutated copy of the gene to pass it on to their children.
Studies have suggested that individuals of Ashkenazi Jewish descent may have a higher prevalence of NTHL1 mutations and associated cancer risks.
Customer Reviews (3)
Write a reviewWith its well-characterized nature and availability in various formats, the arnC protein is an advantageous tool that aids researchers in achieving their scientific goals.
The manufacturer also ensures that the NTHL1 protein is well-characterized, with extensive documentation on its functional properties.
Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.
Ask a Question for All NTHL1 Products
Required fields are marked with *
My Review for All NTHL1 Products
Required fields are marked with *
