NUB1
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Official Full Name
negative regulator of ubiquitin-like proteins 1
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Overview
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinsons disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. -
Synonyms
NUB1; negative regulator of ubiquitin-like proteins 1; NEDD8 ultimate buster 1; BS4; NYREN18; NEDD8 ultimate buster-1; renal carcinoma antigen NY-REN-18; NUB1L;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | NUB1-866H | Recombinant Human NUB1 | Mammalian Cell | His |
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| Human | NUB1-1391H | Recombinant Human NUB1, His-tagged | E.coli | His | 252-601aa | |
| Human | NUB1-3663HCL | Recombinant Human NUB1 293 Cell Lysate | HEK293 | N/A |
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| Human | NUB1-5228H | Recombinant Human NUB1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | NUB1-3692H | Recombinant Human NUB1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | NUB1-3692H-B | Recombinant Human NUB1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | NUB1-10951M | Recombinant Mouse NUB1 Protein | Mammalian Cell | His |
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| Mouse | Nub1-4525M | Recombinant Mouse Nub1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Mouse | NUB1-6240M-B | Recombinant Mouse NUB1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | NUB1-6240M | Recombinant Mouse NUB1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Zebrafish | NUB1-6320Z | Recombinant Zebrafish NUB1 | Mammalian Cell | His |
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| Chicken | NUB1-4888C | Recombinant Chicken NUB1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- NUB1 Related Research Area
NUB1 involved in several pathways and played different roles in them. We selected most pathways NUB1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NUB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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NUB1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUB1 itself. We selected most functions NUB1 had, and list some proteins which have the same functions with NUB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MARVELD2;SPATA22;FBXO4;SERPINA3K;Reln;SRSF1;MAGEA6;BRCA1;DLX2 |
NUB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUB1.
SF3B4; AIPL1; HTT; COPB1; SHFM1
- Q&As
- Reviews
Q&As (5)
Ask a questionScientists are exploring the potential of NUB1 as a target for novel drug development, with the aim of developing therapies for cancer and neurodegenerative diseases.
Research suggests that NUB1 protein levels may serve as a potential biomarker for certain types of cancer, aiding in diagnosis and prognosis.
NUB1 has been linked to diseases such as Alzheimer's and Parkinson's, making it a potential target for therapeutic interventions.
Researchers are exploring ways to modulate the activity of NUB1 protein to inhibit cancer cell growth and promote tumor suppression.
NUB1 protein has been shown to interact with the ubiquitin-proteasome system, influencing the degradation of various proteins involved in disease pathways.
Customer Reviews (3)
Write a reviewIn addition to its outstanding quality, the NUB1 Protein exhibits exceptional stability during storage and usage.
With its remarkable purity and reliability, coupled with the manufacturer's excellent technical support, this protein is a crucial asset in addressing my scientific inquiries and advancing my research goals.
Its ability to maintain structural integrity and stability ensures accurate imaging, enabling me to gain deeper insights into the three-dimensional organization and interactions of the proteins under investigation.
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