NUDT9

Official Full Name

nudix (nucleoside diphosphate linked moiety X)-type motif 9

Background

The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms

NUDT9; nudix (nucleoside diphosphate linked moiety X)-type motif 9; ADP-ribose pyrophosphatase, mitochondrial; MGC3037; mitochondrial; Adenosine diphosphoribose pyrophosphatase; ADP ribose diphosphatase; ADP ribose phosphohydrolase; ADP ribose pyrophosphatase, mitochondrial precursor; ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ADP-ribose pyrophosphatase; ADPR PPase; ADPR-PPase; EC 3.6.1.13; Nucleoside diphosphate linked moiety X motif 9; Nucleoside diphosphate-linked moiety X motif 9; Nudix motif 9; NUDT9_HUMAN; ADP-ribose pyrosphosphatase NUDT9; nucleoside diphosphate linked moiety X-type motif 9; NUDT10