NUMBL
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Official Full Name
numb homolog (Drosophila)-like
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Overview
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. -
Synonyms
NUMBL; numb homolog (Drosophila)-like; NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE; numb-like protein; numb homolog-like; numb-related protein;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | NUMBL-673H | Recombinant Human NUMBL | Mammalian Cell | His |
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| Human | NUMBL-1410H | Recombinant Human NUMBL | E.coli | N/A | ||
| Human | NUMBL-1411H | Recombinant Human NUMBL, GST-tagged | E.coli | GST | 0-280AA | |
| Human | NUMBL-1981H | Recombinant Human NUMBL Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | NUMBL-3700H-B | Recombinant Human NUMBL Protein Pre-coupled Magnetic Beads | HEK293 |
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| Human | NUMBL-900H | Recombinant Human NUMBL Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | NUMBL-5304H | Recombinant Human NUMBL Protein (Ala60-Lys204), N-His tagged | E.coli | N-His | Ala60-Lys204 |
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| Human | NUMBL-3700H | Recombinant Human NUMBL Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Numbl-4548M | Recombinant Mouse Numbl Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Zebrafish | NUMBL-2030Z | Recombinant Zebrafish NUMBL | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- NUMBL Related Articles
NUMBL involved in several pathways and played different roles in them. We selected most pathways NUMBL participated on our site, such as Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUMBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | LNX1;RBPJB;CIR1;DTX3;NOTCH3;NOTCH1A;DLA;HES1;NOTCH4 |
NUMBL has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUMBL itself. We selected most functions NUMBL had, and list some proteins which have the same functions with NUMBL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | A2M;SPRR1A;FBP1;FAIM;CRY1A;LIN37;DCAF11;CHRDL2;ING1 |
NUMBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUMBL here. Most of them are supplied by our site. Hope this information will be useful for your research of NUMBL.
RBFOX1; EGFR; PSMA3; TRAF5; BHLHE40; GAA; ACTN1; THPO; ATXN1; RIPK1; TMC5; spoIVA; SIAH1; ESRP2; TAB2; GPATCH8; TRAF6; MAGED1
- Q&As
- Reviews
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