NXN
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Official Full Name
nucleoredoxin
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Synonyms
NXN; nucleoredoxin; FLJ12614; NRX; nucleoredoxin 1; NXN_HUMAN; OTTHUMP00000115356; TRG 4; TRG-4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
NXN involved in several pathways and played different roles in them. We selected most pathways NXN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NXN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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NXN has several biochemical functions, for example, protein-disulfide reductase activity, thioredoxin-disulfide reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NXN itself. We selected most functions NXN had, and list some proteins which have the same functions with NXN. You can find most of the proteins on our site.
Function | Related Protein |
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protein-disulfide reductase activity | |
thioredoxin-disulfide reductase activity | TXNRD1;TXNRD2;TXNRD3;NXN;TRR1 |
NXN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NXN here. Most of them are supplied by our site. Hope this information will be useful for your research of NXN.
USP3; SEC63
- Q&As
- Reviews
Q&As (6)
Ask a questionThe applications of NXN in tumor treatment include: (1) direct killing of tumor cells and inhibition of tumor growth by carrying chemotherapy drugs, siRNAs, etc.; (2) enhanced immunotherapy, which enhances the body's immune response by carrying immunomodulators or vaccines, (3) anti-angiogenic therapy, which inhibits tumor angiogenesis by inhibiting the expression of angiogenesis, and (4) radiotherapy sensitization, which improves the effect of radiotherapy by carrying radioisotopes.
NXN has the following advantages: (1) high drug loading capacity, which can achieve precise drug delivery, (2) biocompatibility and biodegradability, and no toxic side effects to the body, (3) it can achieve sustained and controlled release of drugs to improve the effect of drug treatment, and (4) it has tumor targeting and cell membrane penetration, which can be used for tumor treatment.
The preparation methods of NXN include physicochemical methods and biochemical methods. Among them, the physical and chemical methods include nanoimprint, nanotemplate method, solvent volatilization method and emulsion method, and the biochemical methods include molecular self-assembly, gene coding and cell membrane coating. These methods can be prepared according to the specific application needs.
The performance of NXN is mainly evaluated by the following aspects: (1) particle size and morphology analysis, which is characterized by nanoparticle size analyzer, scanning electron microscopy and transmission electron microscopy, (2) drug loading and release performance, which is evaluated by drug content determination and in vitro release experiments, (3) biocompatibility and safety evaluation, cytotoxicity experiments, acute toxicity experiments and immunogenicity evaluation, etc., (4) targeting and in vivo distribution, Fluorescence imaging techniques and other methods to observe.
In addition to oncology treatment, NXN can also be used in other areas of drug delivery. For example, NXN is used in gene therapy as a carrier for gene drugs such as siRNA and miRNA, NXN is used in antimicrobial therapy as a carrier for antibiotic drugs, and NXN is used in the treatment of neurodegenerative diseases as a carrier for neuroprotective drugs.
The effect of NXN in tumor treatment is mainly evaluated through the following aspects: (1) tumor growth inhibition effect, observing the growth of tumor after NXN treatment, (2) survival evaluation, observing the survival time of animals after NXN treatment, (3) enhancing immune response effect, detecting the changes of immune indicators of the body after NXN treatment, and (4) safety evaluation, detecting the toxicity and side effects of animals after NXN treatment.
Customer Reviews (3)
Write a reviewIt has good stability in different environments, with thermal stability, acid and alkali stability.
The storage method is simple, and there is no need to prepare a special environment.
It is highly safe and can be used with confidence.
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