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GABPA

  • Official Full Name

    GA binding protein transcription factor, alpha subunit 60kDa

  • Overview

    This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    GABPA; GA binding protein transcription factor, alpha subunit 60kDa; GA binding protein transcription factor, alpha subunit (60kD); GA-binding protein alpha chain; E4TF1 60; E4TF1A; human nuclear respiratory factor 2 subunit alpha; NFT2; NRF2; NRF2A; nucl;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GABPA-482H Recombinant Human GABPA Mammalian Cell His
Human GABPA-6071HCL Recombinant Human GABPA 293 Cell Lysate HEK293 N/A
Human GABPA-102H Recombinant Human GABPA Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human GABPA-554H Recombinant Human GABPA Protein, His-tagged E.coli His Ala168~Thr314
Human GABPA-2992H Recombinant Human GABPA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GABPA-4631H Recombinant Human GABPA Protein, GST-tagged Wheat Germ GST
Human GABPA-5179HF Recombinant Full Length Human GABPA Protein, GST-tagged In Vitro Cell Free System GST 454 amino acids
Human GABPA-2992H-B Recombinant Human GABPA Protein Pre-coupled Magnetic Beads HEK293
Mouse GABPA-6143M Recombinant Mouse GABPA Protein Mammalian Cell His
Mouse GABPA-3426M Recombinant Mouse GABPA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GABPA-3426M-B Recombinant Mouse GABPA Protein Pre-coupled Magnetic Beads HEK293
Mouse Gabpa-3126M Recombinant Mouse Gabpa Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque GABPA-1790R Recombinant Rhesus monkey GABPA Protein, His-tagged Mammalian Cell His
Rhesus Macaque GABPA-1611R Recombinant Rhesus Macaque GABPA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GABPA-1611R-B Recombinant Rhesus Macaque GABPA Protein Pre-coupled Magnetic Beads HEK293
Zebrafish GABPA-9128Z Recombinant Zebrafish GABPA Mammalian Cell His
Chicken GABPA-1781C Recombinant Chicken GABPA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

GABPA involved in several pathways and played different roles in them. We selected most pathways GABPA participated on our site, such as Energy Metabolism, Mitochondrial biogenesis, Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Energy MetabolismMEF2B;MYBBP1A;UCP3;ESRRA;TFB2M;TFB1M;GABPA;PPARGC1B;UCP2
Mitochondrial biogenesisMTERF;TFB2M;PPARGC1B;GABPA;TFB1M;C10orf2;POLRMT;PPRC1;ESRRA
Myometrial Relaxation and Contraction PathwaysMAFF;RGS16;RGS11;RAMP3;IGFBP4;RAMP2;CORIN;RGS6;GABPB1
Organelle biogenesis and maintenanceIFT52;PKD2;TUFM;EXOC6;MRPS27;TNPO1;UNC119B;MRPL40;MRPS30
Transcriptional activation of mitochondrial biogenesisMTERF;PPRC1;POLRMT;GABPB1;TFB1M;GABPA;C10orf2;POLG2

GABPA has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GABPA itself. We selected most functions GABPA had, and list some proteins which have the same functions with GABPA. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF469;HEMK1;FEZF1;RORAA;HIST1H3H;MNX2A;SCMH1;SP8;ZBTB2
RNA polymerase II core promoter proximal region sequence-specific DNA bindingNPAS4;ZNF100;MAX;PDX1;TTC6;TGIF1;NFE2L3;KLF5;BATF2
chromatin bindingRUNX2;MLL1;KDM1A;POU4F2;BCL6;DLX2;HCFC1;ATF2;MEIOB
protein bindingIL12A;SLX1B;SHC1;PIF1;TUBGCP2;FAM98A;STIM2;TRIM2;DNAJB9
protein heterodimerization activityFLOT2;SOX14;CD3E;NFYBB;LIMK2;DRD1;TFAP2B;BAXB;HIST1H2AI
transcription coactivator activityARID1A;SUB1B;SMARCB1;TADA2A;NR1I2;MED14;BRCA1;SUB1;NFE2L3
transcription factor activity, sequence-specific DNA bindingATOH1;FOXD1L;DMRTA1;PBX3B;ZNF239;SMAD7;PRRXL1;EGR2B;NFE2L2A
transcription regulatory region DNA bindingFOS;CREB3L2;ATF4;DHX36;BCL11B;DLX5;GATA5;ATMIN;SIX1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingZFP750;POU2F3;TCF12;POU4F2;NR2E1;MAFB;GATA2;NPAS4;RAX
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingMAF;REST;CEBPA;GABPA;DMRT1;BARHL2;MSGN1;SOHLH1;GATA5

GABPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABPA here. Most of them are supplied by our site. Hope this information will be useful for your research of GABPA.

SP1; SP3; HCFC1; ADGRB2; PINX1; brca1_human_gene

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