OPA1
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Official Full Name
optic atrophy 1 (autosomal dominant)
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Overview
This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
OPA1; optic atrophy 1 (autosomal dominant); dynamin-like 120 kDa protein, mitochondrial; dynamin like guanosine triphosphatase; FLJ12460; KIAA0567; MGM1; mitochondrial dynamin like GTPase; NPG; NTG; optic atrophy protein 1; mitochondrial dynamin-like GTPa;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Oncorhynchus masou (Cherry salmon) (Masu salmon)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | OPA1-30511TH | Recombinant Human OPA1 | Wheat Germ | N/A | 110 amino acids |
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| Human | OPA1-1251HCL | Recombinant Human OPA1 cell lysate | N/A |
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| Human | OPA1-1580H | Recombinant Human OPA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | OPA1-3996H | Recombinant Human OPA1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | OPA1-4769H | Recombinant Human OPA1 Protein (Ser607-Lys960), N-His tagged | E.coli | N-His | Ser607-Lys960 |
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| Human | OPA1-2529H | Recombinant Human OPA1 Protein, His-tagged | E.coli | N-His | Gln285-Glu561 |
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| Human | OPA1-31HFL | Recombinant Full Length Human OPA1 Protein, C-Flag-tagged | Mammalian cells | Flag |
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| Human | OPA1-1580H-B | Recombinant Human OPA1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Opa1-4592M | Recombinant Mouse Opa1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | OPA1-4187R | Recombinant Rat OPA1 Protein | Mammalian Cell | His |
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| Rat | OPA1-3849R | Recombinant Rat OPA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | OPA1-3849R-B | Recombinant Rat OPA1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Danio rerio (Zebrafish) (Brachydanio rerio) | RFL9186DF | Recombinant Full Length Danio Rerio Dynamin-Like 120 Kda Protein, Mitochondrial(Opa1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (194-966) |
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| Gallus gallus (Chicken) | RFL34073GF | Recombinant Full Length Chicken Dynamin-Like 120 Kda Protein, Mitochondrial(Opa1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (212-977) |
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| Homo sapiens (Human) | RFL6000HF | Recombinant Full Length Human Dynamin-Like 120 Kda Protein, Mitochondrial(Opa1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (195-960) |
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| Mus musculus (Mouse) | RFL2438MF | Recombinant Full Length Mouse Dynamin-Like 120 Kda Protein, Mitochondrial(Opa1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (195-960) |
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| Oncorhynchus masou (Cherry salmon) (Masu salmon) | RFL3139OF | Recombinant Full Length Oncorhynchus Masou Dynamin-Like 120 Kda Protein, Mitochondrial(Opa1) Protein, His-Tagged | E.coli expression system | His | Full Length (201-971) |
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| Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL12897PF | Recombinant Full Length Pongo Abelii Dynamin-Like 120 Kda Protein, Mitochondrial(Opa1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (195-960) |
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| Rattus norvegicus (Rat) | RFL24154RF | Recombinant Full Length Rat Dynamin-Like 120 Kda Protein, Mitochondrial(Opa1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (195-960) |
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| Zebrafish | OPA1-1692Z | Recombinant Zebrafish OPA1 | Mammalian Cell | His |
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| Chicken | OPA1-3368C | Recombinant Chicken OPA1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- OPA1 Related Articles
OPA1 involved in several pathways and played different roles in them. We selected most pathways OPA1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with OPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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OPA1 has several biochemical functions, for example, GTP binding, GTPase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OPA1 itself. We selected most functions OPA1 had, and list some proteins which have the same functions with OPA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | DIRAS2;SEPT7A;GNAI1;GNA14;RHOGA;RASD1;RAB10;AK4;TUBA1A |
| GTPase activity | IFT27;TUBA3E;ARL1;ARF3;GIMAP7;RAB3DA;GTPBP5;MTG1;RHOJ |
| magnesium ion binding | NEK6;PPA1;COMT;SRPK2;MAPK12;NUDT3;ATP9B;PGP;TSSK2 |
| protein binding | VARS;PLEKHO1;PDLIM2;SH2B3;UBE2Q1;DPCD;DTNA;HDAC7A;UBXN4 |
OPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OPA1.
BNIP3; MYC; SIRT3; LRRK2; KAT2B; PTP4A3
- Q&As
- Reviews
Q&As (6)
Ask a questionThis protein is involved in the maintenance of mitochondrial inner membrane structure and mitochondrial fusion, which is essential for the normal maintenance of mitochondrial function.
OPA1 protein mutations may be involved in the development of type 2 diabetes identified in some studies, but the specific mechanism needs to be further investigated and verified.
In some experimental studies, it has been found that the expression level of OPA1 protein may be up-regulated in some specific tumors, but its specific role and mechanism in tumors still need to be further studied.
The protein is associated with cardiovascular diseases such as myocardial infarction and may affect the survival of heart cells by regulating mitochondrial function and mitochondrial fusion.
OPA1 protein may play a role in intracellular antioxidant responses, maintaining intracellular oxidative balance by affecting mitochondrial function.
OPA1 protein is involved in the functional regulation of mitochondria in cells, and mitochondrial aging and impaired function are considered to be one of the important factors of cell aging, so OPA1 protein may play a certain role in the process of cell aging.
Customer Reviews (3)
Write a reviewThe purity is good, and the results obtained after analysis by SDS-PAGE or Western blot are good.
OPA1 products are reliable and stable, and are widely used in scientific research, industrial production and medical fields.
When using OPA1 protein for experiments, it is possible to meet specific experimental requirements and research purposes.
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