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OPN5

Official Full Name

opsin 5
Overview

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants.
Synonyms

OPN5; opsin 5; TMEM13, transmembrane protein 13; opsin-5; dJ402H5.1; neuropsin; Gpr136; G protein-coupled receptor 136; G-protein coupled receptor PGR12; HGNC:21318; PGR12; TMEM13; Transmembrane protein 13; G-protein coupled receptor 136;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Chicken
Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)
Zebrafish

Source

E.coli
E.coli expression system
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	OPN5-919H	Recombinant Human OPN5	Mammalian Cell	His		Inquiry
Human	OPN5-2531H	Recombinant Human OPN5 Protein, His-tagged	E.coli	N-His	Met1-Thr181	Inquiry
Human	OPN5-3733H-B	Recombinant Human OPN5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	OPN5-3733H	Recombinant Human OPN5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	OPN5-12172M	Recombinant Mouse OPN5 Protein	Mammalian Cell	His		Inquiry
Mouse	OPN5-6400M	Recombinant Mouse OPN5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	OPN5-6400M-B	Recombinant Mouse OPN5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL22543HF	Recombinant Full Length Human Opsin-5(Opn5) Protein, His-Tagged	E.coli expression system	His	Full Length (1-354)	Inquiry
Mus musculus (Mouse)	RFL35382MF	Recombinant Full Length Mouse Opsin-5(Opn5) Protein, His-Tagged	E.coli expression system	His	Full Length (1-377)	Inquiry
Zebrafish	OPN5-7908Z	Recombinant Zebrafish OPN5	Mammalian Cell	His		Inquiry
Chicken	OPN5-3861C	Recombinant Chicken OPN5	Mammalian Cell	His		Inquiry
	Kit-1449	OPN5 CHO-K1 β-Arrestin Orphan GPCR Assay Kit		N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein

OPN5 involved in several pathways and played different roles in them. We selected most pathways OPN5 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with OPN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)	PNOC;S1PR1;DRD2;INSL5;DRD3;PENK;HCAR1-2;CHRM1;ACKR4
G alpha (i) signalling events	CCR3;CCL27;OPN1MW2;OPN1LW1;ADRA2B;NMU;APPA;OXGR1A.1;CCR9
GPCR downstream signaling	CRH;TAE1;ADM;PTH2;GPR4;APPB;ARHGAP4A;OR10A5;ADORA2A
GPCR ligand binding	GAL;ZFPM2B;NPS;RLN3;GPBAR1;PROKR1A;SSTR1;CRHR1;GCGA
Opsins	OPN4B;OPN4;OPN1LW2;OPN4A;OPN1LW1;OPN1SW1;OPN4.1;OPN5;RGR
Signal Transduction	ARHGAP4A;CIT;WIPF3;KDM4C;FOXH1;MYO9B;ARHGAP18;METAP2B;RDH14B
Signaling by GPCR	PTH;OPN4.1;PTHLHA;GPR77;EMR3;RGS17;INSL5;SCT;GPR31

OPN5 has several biochemical functions, for example, 11-cis retinal binding, G-protein coupled receptor activity, photoreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OPN5 itself. We selected most functions OPN5 had, and list some proteins which have the same functions with OPN5. You can find most of the proteins on our site.

Function	Related Protein
11-cis retinal binding	OPN5;OPN4;RLBP1
G-protein coupled receptor activity	VIPR1B;OR4N4;OR2AP1;OLFR495;OR8U1;RGR;OR52B2;OR4D6;TAS2R104
photoreceptor activity	OPN4A;OPN1MW1;OPN1SW1;EXORH;TMTOPS2B;TMTOPS3B;OPN3;OPN4XB;RHO

OPN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OPN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of OPN5.