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OPRD1

  • Official Full Name

    opioid receptor, delta 1

  • Overview

    The opioid receptors are G-protein coupled, seven-transmembrane domain receptors for enkephalins, endorphins, and dynorphins. Three different opioid receptor subtypes (kappa, delta, and mu) were first identified by their different selectivities for various naturally occurring alkaloid opioid ligands, and subsequently confirmed by molecular cloning. The amino acid sequences of the opioid receptor subtypes are ~70% homologous, and are similar to somatostatin receptors (SSTRs) showing ~40 % homology with SSTR1.
  • Synonyms

    Delta type opioid receptor; Delta type opioid receptor DOR 1; DOR 1; DOR1; mDOR; Nbor; Opioid receptor delta 1; OPRD; OPRD1; delta-type opioid receptor; DOR-1; D-OR-1; OTTHUMP00000003778; delta opioid receptor 1; Opioid Receptor, delta;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli expression system
  • HEK293
  • In vitro E. coli expression system
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human OPRD1-3573HCL Recombinant Human OPRD1 293 Cell Lysate HEK293 N/A
Human OPRD1-3025H Recombinant Human OPRD1 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-372aa
Human OPRD1-1145HFL Recombinant Human OPRD1 protein, His&Flag-tagged HEK293 His&Flag 1-372 aa
Rat OPRD1-4193R Recombinant Rat OPRD1 Protein Mammalian Cell His
Rat OPRD1-3855R-B Recombinant Rat OPRD1 Protein Pre-coupled Magnetic Beads HEK293
Rat OPRD1-3855R Recombinant Rat OPRD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL24099HF Recombinant Full Length Human Delta-Type Opioid Receptor(Oprd1) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Mus musculus (Mouse) RFL26823MF Recombinant Full Length Mouse Delta-Type Opioid Receptor(Oprd1) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Rattus norvegicus (Rat) RFL3269RF Recombinant Full Length Rat Delta-Type Opioid Receptor(Oprd1) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Sus scrofa (Pig) RFL32234SF Recombinant Full Length Pig Delta-Type Opioid Receptor(Oprd1) Protein, His-Tagged E.coli expression system His Full Length (1-228)
Kit-1079 Aminopeptidase N (APN/CD13) Activity Assay Kit (Fluorometric) N/A
Kit-0958 TR-FRET LXR alpha Coactivator Assay Kit, goat N/A
Kit-1450 OPRD1 Activated GPCR Internalization Assay Kit N/A
Kit-1451 OPRD1 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1452 cAMP OPRD1 CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • OPRD1 Related Articles
  • OPRD1 Related Research Area

OPRD1 involved in several pathways and played different roles in them. We selected most pathways OPRD1 participated on our site, such as cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with OPRD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayPIK3CG;PDE3A;PRKCE;CREB3L2;PRKG2;MYLK3;ATP2B1;GNAI3;KCNMB4
Sphingolipid signaling pathwayAKT2;MS4A2;TRADD;HRAS;SMPD2;PLD1;PPP2R2B;LASS2;SPTLC3
Neuroactive ligand-receptor interactionNMUR2;CHRNB3B;GHRHR;GHRHRL;GPR35;GRIN1B;TAAR14B;GLP2R;GLRA3

OPRD1 has several biochemical functions, for example, enkephalin receptor activity, neuropeptide binding, opioid receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OPRD1 itself. We selected most functions OPRD1 had, and list some proteins which have the same functions with OPRD1. You can find most of the proteins on our site.

Function Related Protein
enkephalin receptor activityOPRD1B;OPRD1A;OPRD1
neuropeptide bindingNPBWR2;PTGDR2;OPRD1A;OPRK1;GPR1;SSTR2;MRGPRX2;NPY8AR;OPRM1
opioid receptor activityOPRD1B;NPBWR2;OPRK1;SIGMAR1;OPRD1;NPBWR1;OPRD1A;OGFR
protein bindingASTE1;EIF3B;SRI;HIST2H4;GP6;NASP;SH3RF1;GRAP2;ZDHHC17

OPRD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OPRD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OPRD1.

ATP2A2; GPRASP1; ATP2A2; CANX; dpdpe

Saxon, AJ; et al. Commentary on Burns et al. (2015): Retention in buprenorphine treatment. ADDICTION 110:656-657(2015).
Vakonaki, E; Tzatzarakis, M; et al. A commonly intronic variant in OPRD1 is associated with buprenorphine response in former heroin users. TOXICOLOGY LETTERS 229:S95-S95(2014).
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