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ORC1L

Official Full Name

ORC1 origin recognition complex, subunit 1
Overview

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms

ORC1L; PARC1; HSORC1; origin recognition complex subunit 1; OTTHUMP00000009797; OTTHUMP00000009798; replication control protein 1; origin recognition complex, subunit 1-like; origin recognition complex, subunit 1 homolog;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ORC1L-3553HCL	Recombinant Human ORC1L 293 Cell Lysate	HEK293	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ORC1L involved in several pathways and played different roles in them. We selected most pathways ORC1L participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORC1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell cycle	GADD45G;DNA2;SMC3;CDC25B;ENSAB;CLIP1;SETA;HAUS2;CENPJ

ORC1L has several biochemical functions, for example, ATP binding, DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ORC1L itself. We selected most functions ORC1L had, and list some proteins which have the same functions with ORC1L. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ACTR2B;HLTF;MYHZ2;STRADA;CSNK1G2;HSP90AA1.2;NAV3;BMPR1AB;LIMK1
DNA binding	ZFP513;DRL;PUF60;TFB1M;IKZF1;ZNF571;NHEJ1;MSXC;RBPJB
chromatin binding	WAC;ADNP;FEZF2;SAFB;MEIS3;SP110;KDM5A;JMJD5;BRD3
protein binding	ZNF227;SCAMP1;ERH;TRIP6;CATSPERG2;RAD51C;HDAC2;PDIK1L;LSM3

ORC1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORC1L here. Most of them are supplied by our site. Hope this information will be useful for your research of ORC1L.

ORC2; ORC5; ORC3