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ORC2L

Official Full Name

ORC2 origin recognition complex, subunit 2
Overview

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.
Synonyms

ORC2L; origin recognition complex subunit 2; OTTHUMP00000163672; origin recognition complex, subunit 2-like; origin recognition complex protein 2 homolog; origin recognition complex, subunit 2 homolog;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ORC2L-1466H	Recombinant Human ORC2L, His-tagged	E.coli	His	C-term-350aa	$319 / 25ug
Human	ORC2L-3552HCL	Recombinant Human ORC2L 293 Cell Lysate	HEK293	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ORC2L Related Articles

ORC2L involved in several pathways and played different roles in them. We selected most pathways ORC2L participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORC2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell cycle	LIN37;YWHAB;KIF2B;CENPA;CSNK2B;CDC23;RNF168;SMC4;SETA

ORC2L has several biochemical functions, for example, DNA replication origin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ORC2L itself. We selected most functions ORC2L had, and list some proteins which have the same functions with ORC2L. You can find most of the proteins on our site.

Function	Related Protein
DNA replication origin binding	MCM5;ORC4L;MCM10;MCM2;ORC3L;HSPD1;ORC2L;CDC45;ORC4
protein binding	CD58;YARS2;RARS;AGR2;CLCNKB;KHDC1B;SNRNP27;CDC42BPG;POLDIP3

ORC2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORC2L here. Most of them are supplied by our site. Hope this information will be useful for your research of ORC2L.

ORC1; ORC5; MCM10

Wang, L; Huang, JX; et al. Signal Transducer and Activator of Transcription 2 (STAT2) Metabolism Coupling Postmitotic Outgrowth to Visual and Sound Perception Network in Human Left Cerebrum by Biocomputation. JOURNAL OF MOLECULAR NEUROSCIENCE 47:649-658(2012).

Wu, B; Zhang, Y; et al. Gene expression profiles in liver of mouse after chronic exposure to drinking water. JOURNAL OF APPLIED TOXICOLOGY 29:569-577(2009).