Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

ORC4

Official Full Name

origin recognition complex, subunit 4
Overview

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene.
Synonyms

ORC4L; ORC4P; FLJ46668; origin recognition complex subunit 4; OTTHUMP00000162673; origin recognition complex, subunit 4-like; origin recognition complex, subunit 4 homolog; ORC4; origin recognition complex, subunit 4;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Cynomolgus Monkey
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
His|SUMO
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ORC4-30514TH	Recombinant Human ORC4	Wheat Germ	N/A	248 amino acids	Inquiry
Human	ORC4-2850H	Recombinant Human ORC4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	ORC4-703H	Recombinant Human ORC4 Protein (1-436 aa), His-SUMO-tagged	E.coli	His/SUMO	1-436 aa	Inquiry
Human	ORC4-288H	Recombinant Human ORC4 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	ORC4-1558H	Recombinant Human ORC4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Orc4-4600M	Recombinant Mouse Orc4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Cynomolgus Monkey	ORC4-769C	Recombinant Cynomolgus ORC4 Protein, His-tagged	Mammalian Cell	His		Inquiry
Cynomolgus Monkey	ORC4-513C	Recombinant Cynomolgus Monkey ORC4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Cynomolgus Monkey	ORC4-513C-B	Recombinant Cynomolgus Monkey ORC4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	ORC4-12395Z	Recombinant Zebrafish ORC4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ORC4 involved in several pathways and played different roles in them. We selected most pathways ORC4 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell cycle	LIN37;HUS1;ARPP19A;E2F4;RAD21;RAD21A;STAG2A;ODF2B;CDC25A

ORC4 has several biochemical functions, for example, ATP binding, DNA binding, DNA replication origin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ORC4 itself. We selected most functions ORC4 had, and list some proteins which have the same functions with ORC4. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	CLCN7;PIK3R4;CCT6B;SLC27A5;EIF4A3;HLCS;PC;GART;UBE2NB
DNA binding	RBFOX3;SUPV3L1;HUWE1;ADNP2;GABPA;ZZZ3;FOXJ1A;HIST1H2BF;ZNF143B
DNA replication origin binding	CDC45;ORC4L;HSPD1;ORC2L;MCM10;MCM2;ORC3L;MCM5;ORC4
nucleotide binding	RAVER2;RBM5;ATP8B5;KIAA0430;ARF3A;DIRAS1A;LMTK3;MYH11A;TSSK5

ORC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ORC4.