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OSM

  • Official Full Name

    oncostatin M

  • Overview

    Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene. OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction.
  • Synonyms

    OSM; oncostatin M; MGC20461; oncostatin-M; OTTHUMP00000198700;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • Bovine
  • Canine
  • Human
  • Mouse
  • Rat
  • Rhesus macaque
  • Rhesus Macaque
  • Swine
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • Human cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • DDK
  • N/A
  • N
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human OSM-656H Active Recombinant Human OSM, His-tagged, Biotinylated Human Cell His
Human OSM-131H Active Recombinant Human Oncostatin M HEK293 N/A
Human OSM-658H Active Recombinant Human OSM, Fc-tagged Human Cell Fc
Human OSM-657H Active Recombinant Human OSM, Fc-tagged, Biotinylated Human Cell Fc
Human OSM-514H Active Recombinant Human OSM protein HEK293 N/A Met1-Arg221
Human OSM-2106H Active Recombinant Human OSM protein HEK293 N/A Ala 26 - Arg 252
Human OSM-346H Recombinant Human Oncostatin M, His-tagged Human His
Human OSM-1472H Recombinant Human OSM, His-tagged E.coli His C-227aa
Human OSM-513H Recombinant Human OSM protein HEK293 227
Human OSM-358H Recombinant Human Oncostatin M Human N/A
Human OSM-25H Recombinant Human OSM protein E.coli N/A 227
Human OSM-259H Recombinant Human OSM, StrepII-tagged Human Cell Strep II 26-220, 195 a.a.
Human OSM-6998H Active Recombinant Human OSM protein, His-tagged HEK293 His Met1-Arg221
Human OSM-206H Recombinant Human OSM, His-tagged E.coli His
Human OSM-964H Recombinant Human OSM Protein E.coli N/A
Human OSM-463H Recombinant Human OSM protein, His-tagged HEK293F His Ala26~Arg220
Human OSM-759H Recombinant Human OSM protein, His & GST-tagged E.coli His/GST Ala26~Arg220
Human OSM-962H Recombinant Human OSM protein E.coli N/A 195
Human OSM-963H Recombinant Human OSM protein E.coli N/A 209
Human OSM-1766HCL Recombinant Human OSM cell lysate Human Cell N/A
Human OSM-4374H Recombinant Human OSM Protein Yeast N/A 196aa
Human OSM-111H Recombinant Human OSM Protein, His-tagged E.coli His
Human OSM-220H Active Recombinant Human OSM Protein E.coli
Human OSM-31H Recombinant Human OSM Protein E.coli
Human OSM-321O Active Recombinant Human OSM Protein (228 aa) E.coli 228
Human OSM-945HFL Recombinant Full Length Human OSM Protein, C-Flag-tagged Mammalian cells Flag
Human OSM-43H Active Recombinant Human OSM Protein, Animal Free Human cells
Human OSM-065O Active Recombinant Human OSM Protein (227 aa) E.coli 227
Human OSM-322O Active Recombinant Human OSM Protein (210 aa) E.coli 210
Human OSM-307H Active Recombinant Human OSM Protein E.coli Tag Free
Human OSM-064O Active Recombinant Human OSM Protein (209 aa) E.coli 209
Human OSM-725HB Recombinant Human OSM protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala26-Arg221
Human OSM-2601H Active Recombinant Human OSM protein E.coli N/A Ala26-Arg221
Human OSM-4771H Recombinant Human OSM Protein (Met1-Arg221), C-His tagged Mammalian cells C-His Met1-Arg221
Human OSM-1589H Recombinant Human OSM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human OSM-725H Recombinant Human OSM protein, His-Avi-tagged HEK293 His-Avi Ala26-Arg221
Human OSM-5257H Recombinant Human OSM protein, GST-tagged E.coli GST 26-220aa
Human OSM-4772H Recombinant Human OSM Protein (Ala26-Arg252), C-His tagged Mammalian cells C-His Ala26-Arg252
Human OSM-522H Recombinant Human OSM Protein 252
Human OSM-437HG Active GMP Recombinant Human OSM protein HEK293 DNA sequence encoding Human Oncostatin M(NCBI Reference Sequence: NP_065391.1) was expressed with His tag at the C-terminal.
Human OSM-5489H Recombinant Human OSM protein, His-tagged Yeast His 26-220aa
Human OSM-4773H Recombinant Human OSM Protein (Ala26-Arg221), His tagged E.coli His Ala26-Arg221
Human OSM-1589H-B Recombinant Human OSM Protein Pre-coupled Magnetic Beads HEK293
Human OSM-130H Human Oncostatin M (rDNA derived) Reference standard N/A
Mouse Osm-8302M Active Recombinant Mouse Osm E.coli N/A
Mouse Osm-841M Active Recombinant Mouse Osm Protein, His-tagged HEK293 His
Mouse Osm-524M Recombinant Mouse Osm protein E.coli N/A 181
Mouse Osm-1771M Recombinant Mouse Oncostatin M Mammalian cells N/A
Mouse Osm-760M Recombinant Mouse Osm protein, His-tagged E.coli His Asn25~Leu115
Mouse OSM-1659MCL Recombinant Mouse OSM cell lysate Human Cell N/A
Mouse Osm-5214M Recombinant Mouse Osm protein E.coli N/A Ala24-Arg206
Mouse Osm-4358M Recombinant Mouse Osm Protein Yeast N/A 182aa
Mouse Osm-10606M Recombinant Mouse Osm Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Osm-168O Active Recombinant Mouse Osm Protein HEK293
Mouse Osm-10606M-B Recombinant Mouse Osm Protein Pre-coupled Magnetic Beads HEK293
Mouse Osm-320O Active Recombinant Mouse Osm Protein (182 aa) E.coli 182
Mouse Osm-4619M Recombinant Mouse Osm Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Osm-585R Recombinant Rat Osm protein E.coli N/A 214
Rat OSM-4208R Recombinant Rat OSM Protein Mammalian Cell His
Rat Osm-5106R Recombinant Rat Osm protein, His-tagged HEK293 His 26-208aa
Rat Osm-1886R Recombinant Rat Osm Protein, His-tagged E.coli N-His Lys26-Pro116
Rat Osm-4527R Recombinant Rat Osm protein, His-tagged E.coli His 26-208aa
Rat Osm-5782R Recombinant Rat Osm protein, His-tagged Yeast His 26-208aa
Rat Osm-319O Active Recombinant Rat Osm Protein (215 aa) E.coli 215
Rat OSM-3870R Recombinant Rat OSM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat OSM-3870R-B Recombinant Rat OSM Protein Pre-coupled Magnetic Beads HEK293
Bovine OSM-4337B Recombinant Bovine OSM Protein Yeast N/A 180aa
Canine OSM-4338C Recombinant Canine OSM Protein Yeast N/A 181aa
Rhesus Macaque OSM-3255R Recombinant Rhesus monkey OSM Protein, His-tagged Mammalian Cell His
Rhesus macaque OSM-5550R Recombinant Rhesus macaque OSM protein Yeast N/A 1-231aa
Rhesus macaque OSM-5551R Recombinant Rhesus macaque OSM protein, His-Myc-tagged Yeast His/Myc 1-231aa
Rhesus Macaque OSM-3073R-B Recombinant Rhesus Macaque OSM Protein Pre-coupled Magnetic Beads HEK293
Rhesus macaque OSM-2267R Recombinant Rhesus macaque OSM protein, His-tagged Insect Cell His 1-231aa
Rhesus Macaque OSM-3073R Recombinant Rhesus Macaque OSM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Swine OSM-4391S Recombinant Swine OSM Protein Yeast N/A 181aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • OSM Related Articles
  • OSM Related Research Area

OSM involved in several pathways and played different roles in them. We selected most pathways OSM participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCCL21B;GM1987;CCL19;IL17RB;IL7;INHBE;TNFSF9;GM10591;GM13305
PIK-Akt signaling pathwayIL2RA;EIF4E2;IFNA12;IFNA7;PIK3CA;PIK3CD;ITGB5;CASP9;PCK1
Jak-STAT signaling pathwayFHL1;IL21R;THPO;CSH2;IL21R.1;SOCS3B;IL4R;IFNPHI1;GM2002

OSM has several biochemical functions, for example, cytokine activity, growth factor activity, oncostatin-M receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OSM itself. We selected most functions OSM had, and list some proteins which have the same functions with OSM. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIL17F;IL17A/F3;TNFSF4;HMGB1;IL5;Il23a; Il12b;IL18;GDF11;Ccl12
growth factor activityINHBA;KLK1B3;VEGFA;NTF4;PDGFAA;FGF18B;HBEGF;BMP8A;NRG4
oncostatin-M receptor binding

OSM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSM here. Most of them are supplied by our site. Hope this information will be useful for your research of OSM.

IL6ST; LIFR; COL4A6; TNNT1

Lapeire, L; Hendrix, A; et al. Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling. CANCER RESEARCH 74:6806-6819(2014).
Torres, C; Perales, S; et al. Serum Cytokine Profile in Patients With Pancreatic Cancer. PANCREAS 43:1042-1049(2014).
  • Q&As
  • Reviews

Q&As (7)

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What is the impact of OSM on cancer development and progression, particularly in terms of tumor microenvironment modulation? 03/25/2022

OSM can influence cancer progression by altering the tumor microenvironment and affecting tumor cell behavior.

How does OSM (Oncostatin M) regulate inflammatory and immune responses in the body? 01/30/2021

OSM plays a key role in regulating inflammatory and immune responses, modulating cytokine production and immune cell activity.

How does OSM contribute to wound healing and tissue regeneration processes? 06/08/2020

OSM aids in wound healing and tissue regeneration, promoting cell growth and repair mechanisms.

What role does OSM play in the pathogenesis of autoimmune diseases like rheumatoid arthritis? 04/27/2020

OSM is implicated in autoimmune diseases, contributing to inflammation and joint damage in conditions like rheumatoid arthritis.

How does OSM influence liver fibrosis and hepatic diseases? 03/17/2020

OSM is involved in liver fibrosis, impacting the development and progression of hepatic diseases.

What are the mechanisms by which OSM modulates cellular growth, differentiation, and apoptosis? 06/22/2018

OSM regulates cellular processes like growth, differentiation, and apoptosis, affecting various tissue functions.

How do alterations in OSM expression or signaling affect cardiovascular health and disease? 02/20/2018

Changes in OSM signaling can impact cardiovascular health, influencing disease development and progression.

Customer Reviews (3)

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Reviews
11/25/2020

    Outstanding protein-protein interaction studies, vital for our projects.

    03/02/2020

      High-quality protein characterization, fundamental for our experiments.

      02/27/2019

        Expertise in peptide synthesis, accelerates our peptide-based research.

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