OTX2
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Official Full Name
orthodenticle homeobox 2
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Overview
OTX2 (Orthodenticle homeobox 2) belongs to the bicoid subfamily of paired-box, homeodomain-containing transcription factors. OTX2 is a critically important neuronal transcription factor that functions to regulate the expression of cell cycle genes control -
Synonyms
OTX2; orthodenticle homeobox 2; orthodenticle homolog 2 (Drosophila); homeobox protein OTX2; orthodenticle homolog 2; CPHD6; MCOPS5; MGC45000;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- C
- His
- SUMO
- N/A
- T7|His
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | OTX2-193H | Recombinant Human OTX2 protein, T7/His-tagged | E.coli | T7/His |
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| Human | OTX2-165H | Recombinant Human OTX2 | E.coli | N/A |
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| Human | OTX2-390H | Recombinant Human OTX2 Protein, His-tagged | E.coli | His |
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| Human | OTX2-26H | Recombinant Human OTX2 Protein, His-tagged | E.coli | His |
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| Human | OTX2-25H | Recombinant Human OTX2 Protein, His-tagged | E.coli | His |
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| Human | OTX2-3511HCL | Recombinant Human OTX2 293 Cell Lysate | HEK293 | N/A |
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| Human | OTX2-4776H | Recombinant Human OTX2 Protein (Met1-Leu297), C-His tagged | E.coli | C-His | Met1-Leu297 |
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| Human | OTX2-3310H | Recombinant Human OTX2 protein, His-SUMO-tagged | E.coli | His-SUMO | 1-297aa |
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| Mouse | Otx2-3311M | Recombinant Mouse Otx2 protein, His-tagged | E.coli | His | 1-289aa |
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| Zebrafish | OTX2-8848Z | Recombinant Zebrafish OTX2 | Mammalian Cell | His |
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| Chicken | OTX2-6089C | Recombinant Chicken OTX2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- OTX2 Related Articles
- OTX2 Related Research Area
OTX2 involved in several pathways and played different roles in them. We selected most pathways OTX2 participated on our site, such as TP53 network, which may be useful for your reference. Also, other proteins which involved in the same pathway with OTX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TP53 network | BOK;OTX2 |
OTX2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, eukaryotic initiation factor 4E binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OTX2 itself. We selected most functions OTX2 had, and list some proteins which have the same functions with OTX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NR1H2;EGR2;FUBP3;SNAI3;RFX2;AEBP2;PAX5;HAND1;NOBOX |
| eukaryotic initiation factor 4E binding | GRA;EIF4G1;HHEX;EIF4EBP3L;EIF4EBP3;LARP1;EIF4EBP2;OTX2;EIF4EBP1 |
| protein binding | CC10;GABPB2;LCP2;ATE1;S100A12;TMEM67;NFKBIB;CDK10;RIC8 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NFKB2;TFAP2E;ZFAT;MZF1;ELF3;LEF1;TFAP2C;TCF4;NR1H4 |
OTX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OTX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of OTX2.
ATXN1; HBZ; CDK4
- Q&As
- Reviews
Q&As (5)
Ask a questionAs of my last knowledge update, there were no specific drugs targeting OTX2 in advanced stages of development, but ongoing research might uncover potential drug candidates.
Yes, gene therapy targeting the OTX2 gene is being investigated as a potential approach for treating disorders related to OTX2 dysfunction.
While not yet widely used in clinical practice, diagnostic tests assessing OTX2 expression levels may become relevant in the future for certain developmental and neurological disorders.
OTX2 has been implicated in certain types of brain tumors, and understanding its role in cancer may provide insights into potential targeted therapies.
As of my last knowledge update in January 2022, specific clinical trials involving OTX2 were not widely reported. However, ongoing research may have progressed since then.
Customer Reviews (3)
Write a reviewThe OTX2 protein is of exceptional quality, meeting all my experimental requirements with precision and reliability.
This dedication ensures that I have access to the most advanced and reliable protein in my studies, enhancing the overall quality and impact of my research outcomes.
This exceptional level of support enables me to overcome challenges efficiently and progress smoothly with my research.
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