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PAK4

  • Official Full Name

    p21 protein (Cdc42/Rac)-activated kinase 4

  • Overview

    Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
  • Synonyms

    PAK4 + PAK5 + PAK6; PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4; PAK-4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • GST,His
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PAK4-18H Active Recombinant Human PAK4 E.coli N/A
Human PAK4-180H Active Recombinant Human PAK4(295-end) Protein, N-His,N-GST-tagged Sf21 GST,His 295-end
Human PAK4-380H Recombinant Human PAK4, GST-tagged, Active Sf9 Insect Cell GST
Human PAK4-723H Recombinant Human PAK4, GST-His Sf9 Insect Cell GST
Human PAK4-30671TH Recombinant Human PAK4 Insect Cell N/A 591 amino acids
Human PAK4-105H Recombinant Human P21 Protein-activated Kinase 4, His-tagged E.coli His
Human PAK4-69H Recombinant Human PAK4 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human PAK4-1283H Recombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 4, GST-tagged Insect Cell GST
Human PAK4-3455HCL Recombinant Human PAK4 293 Cell Lysate HEK293 N/A
Human PAK4-3456HCL Recombinant Human PAK4 293 Cell Lysate HEK293 N/A
Human PAK4-1966H Recombinant Human PAK4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PAK4-766H Recombinant Human PAK4 Protein, His-tagged E.coli His Val299~Ser542
Human PAK4-3316H Recombinant Human PAK4 protein, His-SUMO-tagged E.coli His-SUMO 1-426aa
Human PAK4-1647HF Active Recombinant Full Length Human PAK4 Protein, GST-tagged Insect (sf21) GST 1-591(end)
Human PAK4-382HFL Recombinant Full Length Human PAK4 Protein, C-Flag-tagged Mammalian cells Flag
Human PAK4-3407HF Active Recombinant Full Length Human PAK4 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-591(end)
Human PAK4-1603H Recombinant Human PAK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PAK4-319H Recombinant Human PAK4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human PAK4-1603H-B Recombinant Human PAK4 Protein Pre-coupled Magnetic Beads HEK293
Human PAK417138H Recombinant Human PAK4 (300-591) Protein
Human PAK4-3888H Recombinant Human PAK4 Protein (Val299-Ser542), His tagged E.coli His Val299-Ser542
Mouse PAK4-12321M Recombinant Mouse PAK4 Protein Mammalian Cell His
Mouse PAK4-6475M-B Recombinant Mouse PAK4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Pak4-1894M Recombinant Mouse Pak4 Protein, His-tagged E.coli N-His Ser46-Ile339
Mouse Pak4-4663M Recombinant Mouse Pak4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PAK4-6475M Recombinant Mouse PAK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PAK4-439Z Recombinant Zebrafish PAK4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PAK4 Related Articles
  • PAK4 Related Research Area
  • PAK4 Related Signal Pathway

PAK4 involved in several pathways and played different roles in them. We selected most pathways PAK4 participated on our site, such as Activation of Rac, Axon guidance, CDC42 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of Rac
Axon guidanceABL1;EPHA8;NRP1A;RHOGA;EPHB3;CSF2;EFNA4;SRGAP1;EFNA1A
CDC42 signaling eventsBAIAP2;ARPC3;ARPC2;ACTR2;PAK4;CTNNA1;CFL1;ARPC4;CDC42BPA
Developmental BiologyEFNA1;DNM1;SMAD3B;LGI1B;CFC1;TCF12;IL17RD;GDF1;KIF4
ErbB signaling pathwayNRG1;ABL2;PRKCB;EGFRA;PAK1;AKT2;MAPK3;PIK3CA;PRKCA
FGF signaling pathwayJUNBA;BGLAP;EGR2B;FGFRL1B;SOX32;FGF24;EGR2A;SP8B;TA
Focal AdhesionGRB2;SHC4;VASP;ITGA11A;PAK2A;VWF;RAF1;ITGA2B;CCND3

PAK4 has several biochemical functions, for example, ATP binding, Rac GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK4 itself. We selected most functions PAK4 had, and list some proteins which have the same functions with PAK4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTNK1;CSNK1G3;CDK7;CSNK1DA;PRKCBB;KSR1;TCP1;CCT8;SARS
Rac GTPase bindingCORO1C;SRGAP3;RAB7A;FMNL1;ARHGEF2;PAK4;ARHGAP4A;SOD1;CDKL5
protein bindingHTR3C;PIH1D1;UGP2;EXOSC8;LDHB;IRF2BP1;ACO1;CSTF1;PGF
protein kinase activityACVR1;MAP3K5;CSNK1DB;MMD2;LMTK2;MAP2K1;CSNK1A1;TBRG4;MAP4K3
protein serine/threonine kinase activityMAP2K1;STK36;MAP2K5;RPS6KA1;VPRBP;MAPK4;BMPR2A;RPS6KA3B;IKBKB

PAK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK4.

YWHAZ; CDC42; YWHAG; YWHAB; TERF1; SRPK2; SRPK1; YWHAQ; SFN; LRRK1; ARHGEF2; DLST; GATAD2A

Kesanakurti, D; Chetty, C; et al. Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma. CELL DEATH & DISEASE 3:-(2012).
Zhang, HJ; Siu, MKY; et al. Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma. CARCINOGENESIS 32:765-771(2011).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any FDA-approved drugs targeting PAK4? 12/19/2021

As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting PAK4.

Are there any diagnostic tests based on PAK4 for cancer screening? 05/19/2021

PAK4 is not commonly used as a specific diagnostic marker for cancer screening. Other markers, like PSA for prostate cancer or mammography for breast cancer, are more common.

What are the current clinical trials involving PAK4 inhibitors? 06/26/2020

Clinical trials involving PAK4 inhibitors may vary over time. To find the latest information, you should consult clinical trial databases or healthcare professionals.

What are the challenges in developing PAK4 inhibitors for clinical use? 02/08/2020

Selectivity and potential side effects are challenges in developing PAK4 inhibitors, which need to be carefully addressed in clinical trials.

How is PAK4-related research contributing to personalized medicine? 05/14/2019

PAK4-related research may help identify specific patient populations that could benefit from PAK4-targeted therapies, contributing to personalized treatment approaches.

Customer Reviews (3)

Write a review
Reviews
11/16/2021

    The prompt and knowledgeable assistance they offer has greatly enhanced my confidence in using the PAK4 protein.

    03/01/2020

      I am highly satisfied with the performance and support associated with this protein, as it has proven to be an essential tool in advancing my scientific investigations.

      05/18/2016

        Its purity and reliability have provided consistent and reliable results in my research.

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