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PAK6

  • Official Full Name

    p21 protein (Cdc42/Rac)-activated kinase 6

  • Overview

    This gene encodes a member of the p21-activated kinase (PAK) family. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. This gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    PAK6; p21 protein (Cdc42/Rac)-activated kinase 6; PAK5; p21-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated protein kinase 6; EC 2.7.11.1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PAK6-19H Active Recombinant Human PAK6 E.coli N/A
Human PAK6-182H Active Recombinant Human PAK6(382-end) Protein, N-His-tagged Sf21 His 382-end
Human PAK6-724H Recombinant Human PAK6, GST-His Sf9 Insect Cell GST
Human PAK6-32H Recombinant Human PAK6 protein, GST-tagged Wheat Germ GST
Human PAK6-1284H Recombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 6, His-tagged Insect Cell His
Human PAK6-381H Recombinant Human PAK6, GST-tagged, Active Sf9 Insect Cell GST
Human PAK6-3454HCL Recombinant Human PAK6 293 Cell Lysate HEK293 N/A
Human PAK6-3616H Recombinant Human PAK6 protein, GST-tagged E.coli GST 97-262 aa
Human PAK6-3177H Recombinant Human PAK6 protein, His-tagged E.coli His 210-370 aa
Human PAK6-1108H Recombinant Human PAK6 Protein (G383-Y674), Tag Free E.coli No tag G383-Y674
Human PAK6-9312HF Active Recombinant Full Length Human PAK6 Protein, GST-tagged Insect (sf21) GST 1-681
Human PAK6-3328H Recombinant Human PAK6 protein, His-tagged E.coli His 97-262 aa
Human PAK6-1109H Recombinant Human PAK6 Protein (G383-Y674), His tagged E.coli His G383-Y674
Human PAK6-704HF Recombinant Full Length Human PAK6 Protein, GST-tagged In Vitro Cell Free System GST 681 amino acids
Mouse PAK6-12322M Recombinant Mouse PAK6 Protein Mammalian Cell His
Mouse PAK6-6476M Recombinant Mouse PAK6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PAK6-6476M-B Recombinant Mouse PAK6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PAK6-3292R Recombinant Rhesus monkey PAK6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PAK6-3110R Recombinant Rhesus Macaque PAK6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PAK6-3110R-B Recombinant Rhesus Macaque PAK6 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PAK6 Related Articles
  • PAK6 Related Research Area
  • PAK6 Related Signal Pathway

PAK6 involved in several pathways and played different roles in them. We selected most pathways PAK6 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayNCK2A;PAK2B;NRAS;CAMK2B;SHC3;PIK3R2;CDKN1BB;PRKCG;MAPK8A
Ras signaling pathwayRAB5B;GNG4;RELA;RAC2;NGFR;GNB4;PRKCG;STK4;PDGFA
Axon guidanceEFNA5;PLXNA1;CAP2;RNF8;TRPC5;KLB;EGF;AP2B1;NRG3
Focal adhesionCOL27A1B;ITGA2B;PPP1R12C;VTNB;RHOAB;LAMB1A;MYL2;VAV2;MYLPF
T cell receptor signaling pathwayBCL10;CD4;CDC42;Il2;PPP3CC;CBLC;DLG1;ZAP70;MAPK1
Regulation of actin cytoskeletonPIP5K1AA;IQGAP3;DIAPH3;PIP4K2AA;INSB;PIP5K1B;F2R;FGF6B;FGF7
Renal cell carcinomaGRB2;PIK3R2;RAC1;MET;PIK3R3;EGLN1;SOS1;PAK1;RBX1

PAK6 has several biochemical functions, for example, ATP binding, Rac GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK6 itself. We selected most functions PAK6 had, and list some proteins which have the same functions with PAK6. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAPK6;FAM20B;DDX42;ACTA1A;LIMK2;PDIK1L;UBE2C;FGFR1B;PRKACB
Rac GTPase bindingITPKA;SRGAP2;ARFIP2;PAK4;RALBP1;SRGAP2B;PAK6;CAV1;RAB7
protein bindingCCL5;UBE2G2;PLEKHG4;MPDU1;IL6;FRAS1;RAB3B;VPREB1;NHLH2
protein serine/threonine kinase activityLMTK3;ROCK2B;TRIO;TAOK2;MAPK8A;CSNK1DB;TTBK2;C9orf96;MAPK1

PAK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK6.

LRRK2; RHOJ; PKM; LRRK1; HSP90AB1; YWHAQ; SNX2; CDK1; CDC42; SEMA3B; MAPK14; TPD52L1; NEK6

Liu, WS; Liu, HO; et al. Prognostic Significance of p21-activated Kinase 6 Expression in Patients with Clear Cell Renal Cell Carcinoma. ANNALS OF SURGICAL ONCOLOGY 21:S575-S583(2014).
Zapatero, A; Morente, M; et al. Predictive value of PAK6 and PSMB4 expression in patients with localized prostate cancer treated with dose-escalation radiation therapy and androgen deprivation therapy. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32:1327-1332(2014).
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