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PAN2

  • Official Full Name

    PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

  • Overview

    This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3 to 5 exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants.
  • Synonyms

    PAN2; PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); ubiquitin specific peptidase 52 , ubiquitin specific protease 52 , USP52; PAB-dependent poly(A)-specific ribonuclease subunit 2; hPAN2; KIAA0710; PAN2 homolog; PABP1 dependent poly A specific ribonuclease subunit (S. cerevisiae); Inactive ubiquitin carboxyl terminal hydrolase 52; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB dependent poly(A) specific ribonuclease subunit 2; PABP dependent poly(A) nuclease 2; PAN 2; PAN2 homolog PABP1 dependent poly A specific ribonuclease subunit; PAN2 poly(A) specific ribonuclease subunit homolog; PAN2 polyA specific ribonuclease subunit homolog; PAN2_HUMAN; Ubiquitin specific peptidase 52; Ubiquitin specific protease 52; USP 52; USP52; OTTHUMP00000243750; OTTHUMP00000243751; OTTHUMP00000243752; PABP-dependent poly(A) nuclease 2; PAN2 polyA specific ribonuclease subunit; inacti;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PAN2-3446HCL Recombinant Human PAN2 293 Cell Lysate HEK293 N/A
Human PAN2-3540H Recombinant Human PAN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse PAN2-12331M Recombinant Mouse PAN2 Protein Mammalian Cell His
Mouse PAN2-6482M Recombinant Mouse PAN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pan2-224M Recombinant Mouse Pan2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse PAN2-6482M-B Recombinant Mouse PAN2 Protein Pre-coupled Magnetic Beads HEK293
Rat PAN2-4265R Recombinant Rat PAN2 Protein Mammalian Cell His
Rat PAN2-3927R Recombinant Rat PAN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PAN2-3927R-B Recombinant Rat PAN2 Protein Pre-coupled Magnetic Beads HEK293
Chicken PAN2-2165C Recombinant Chicken PAN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PAN2 Related Articles

PAN2 involved in several pathways and played different roles in them. We selected most pathways PAN2 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA degradationTOB1;SKIV2L;LSM3;EXOSC9;EXOSC3;EXOSC4;DCP2;PFKM;CNOT6L

PAN2 has several biochemical functions, for example, 3-5-exoribonuclease activity, nucleic acid binding, poly(A)-specific ribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAN2 itself. We selected most functions PAN2 had, and list some proteins which have the same functions with PAN2. You can find most of the proteins on our site.

Function Related Protein
3-5-exoribonuclease activityTOE1;USB1;SMFN;CNOT7;ERI1;EXOSC5;DIS3;DOM3Z;DIS3L2
nucleic acid bindingZFP382;NARS2;KRBOX4;ZNF728;ZBED6;TREX2;ZFP574;KLF2B;RSFR
poly(A)-specific ribonuclease activityPAN2;PARN;CNOT6;TOE1;PDE12;CNOT6L;CNOT7;CNOT8
protein bindingIVL;PABPC1;MAST2;JMJD6;ZBTB25;COMMD2;FHL2;EIF3D;CEP55

PAN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAN2.

PAN3; ARCN1; VBP1; PLEC; TCEB1; TCEB2; TWF2; CBWD2; NUP93; CCT7; MRPL39; PFDN2; iutA; yubA; q81rg9_bacan

Nishii, Y; Yamaguchi, M; et al. A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1781-1787(2015).
Inami, K; Kajino, K; et al. Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma. ONCOLOGY REPORTS 20:1375-1380(2008).
  • Q&As
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