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PAPSS2

  • Official Full Name

    3-phosphoadenosine 5-phosphosulfate synthase 2

  • Overview

    Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3-phosphoadenosine 5-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.
  • Synonyms

    PAPSS2; 3-phosphoadenosine 5-phosphosulfate synthase 2; bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2; ATPSK2; SK 2; PAPSS 2; PAPS synthase 2; PAPS synthetase 2; ATP sulfurylase/APS kinase 2; ATP sulfurylase/adenosine 5-phosphosulfate kinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PAPSS2-32H Recombinant Human PAPSS2, His-tagged E.coli His
Human PAPSS2-1524H Recombinant Human PAPSS2, His-tagged E.coli His 1-333aa
Human PAPSS2-3440HCL Recombinant Human PAPSS2 293 Cell Lysate HEK293 N/A
Human PAPSS2-5274H Recombinant Human PAPSS2 Protein (Met1-Asn614), C-His tagged Mammalian cells C-His Met1-Asn614
Mouse Papss2-4675M Recombinant Mouse Papss2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque PAPSS2-3299R Recombinant Rhesus monkey PAPSS2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PAPSS2-3117R-B Recombinant Rhesus Macaque PAPSS2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PAPSS2-3117R Recombinant Rhesus Macaque PAPSS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PAPSS2 Related Articles

PAPSS2 involved in several pathways and played different roles in them. We selected most pathways PAPSS2 participated on our site, such as Purine metabolism, Selenocompound metabolism, Sulfur metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismNUDT5;UOX;PDE3A;ADSL;NT5C1B-RDH14;AK8;POLE4;PRPS1B;NT5C2
Selenocompound metabolismMARS2;SPS2;PAPSS2A;SEPHS2;SEPHS1;SEPSECS;PSTK;TXNRD3;PAPSS1
Sulfur metabolismCYCS;ETHE1;cysH;PAPSS2A;TST;PAPSS1;IMPAD1;PAPSS2B;SQRDL
Metabolic pathwaysMTHFD1B;CYP11B1;DHCR7;CHIA.4;GNPDA2;CYP21A1;ALDOB;ATP6V1BA;B3GNT5A

PAPSS2 has several biochemical functions, for example, ATP binding, adenylylsulfate kinase activity, nucleotidyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPSS2 itself. We selected most functions PAPSS2 had, and list some proteins which have the same functions with PAPSS2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCAMK2G1;MKKS;TAF1;NLRC4;ACLYA;UBE2Z;ABCB10;KIAA1804;RTCD1
adenylylsulfate kinase activityPAPSS2A;PAPSS2B;PAPSS2;PAPSS1
nucleotidyltransferase activityPAPSS2;POLN;GKUP;POLE2;TAMM41;TERT;GMPPAA;GDPGP1;REV3L
sulfate adenylyltransferase (ATP) activityPAPSS1;PAPSS2A;PAPSS2B;PAPSS2

PAPSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPSS2.

VHL; Papss1

Miccolis, A; Galluccio, M; et al. Significance of redox-active cysteines in human FAD synthase isoform 2. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:2086-2095(2014).
Iida, A; Simsek-Kiper, PO; et al. Clinical and Radiographic Features of the Autosomal Recessive form of Brachyolmia Caused by PAPSS2 Mutations. HUMAN MUTATION 34:1381-1386(2013).
  • Q&As
  • Reviews

Q&As (5)

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Are there any known inhibitors or activators of PAPSS2, and how could they be applied in a clinical setting? 06/03/2022

Investigations into PAPSS2 modulators are ongoing, and if identified, they could serve as potential therapeutic agents in clinical settings.

How does PAPSS2 contribute to hormone metabolism, and what are the implications for related clinical conditions? 05/03/2022

PAPSS2 is involved in sulfating hormones, impacting their activity. Mutations in PAPSS2 can lead to disorders like steroid sulfatase deficiency, affecting hormone metabolism.

How does the expression of PAPSS2 vary in different tissues and developmental stages? 01/09/2022

PAPSS2 expression varies among tissues and developmental stages, reflecting its diverse roles in different physiological contexts.

Can PAPSS2 be a potential target for drug development? 05/15/2020

Research exploring the therapeutic potential of targeting PAPSS2 is ongoing. It may offer new avenues for drug development in the future.

How does PAPSS2 contribute to the sulfation of sulfatide lipids, and what role do these lipids play in cellular membranes? 10/20/2019

PAPSS2 is involved in sulfating sulfatide lipids, which are crucial for the integrity and function of cellular membranes.

Customer Reviews (3)

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Reviews
03/24/2022

    Whether investigating the role of PAPSS2 in angiogenesis, vascular development, or disease pathways, this protein surpasses expectations and guarantees reliable results.

    08/19/2020

      The PAPSS2 protein is a superior-quality protein that perfectly aligns with my experimental requirements.

      03/11/2020

        Its exceptional purity, consistency, and reliability make it an ideal choice for a wide range of research applications.

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