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PAX5

Official Full Name

paired box 5
Overview

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Synonyms

PAX5; paired box 5; ALL3; BSAP; paired box protein Pax-5; paired domain gene 5; paired box homeotic gene 5; transcription factor PAX 5; B-cell lineage specific activator;

Type

Cell & Tissue Lysates
Recombinant Proteins

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PAX5-3416HCL	Recombinant Human PAX5 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PAX5-3759H	Recombinant Human PAX5 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	PAX5-3663H	Recombinant Human PAX5 protein, His&Myc-tagged	E.coli	His&Myc	1-391aa	Inquiry
Human	PAX5-2551H	Recombinant Human PAX5 Protein, His-tagged	E.coli	N-His	Met1-His391	Inquiry
Mouse	Pax5-4686M	Recombinant Mouse Pax5 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	PAX5-9176Z	Recombinant Zebrafish PAX5	Mammalian Cell	His		Inquiry
Chicken	PAX5-5994C	Recombinant Chicken PAX5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PAX5 Related Articles
PAX5 Related Research Area

PAX5 involved in several pathways and played different roles in them. We selected most pathways PAX5 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Transcriptional misregulation in cancer	MLLT3;PML;MEIS1;Aff1;GRIA3;ETV4;TGFBR2;MMP3;HIST1H3I

PAX5 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX5 itself. We selected most functions PAX5 had, and list some proteins which have the same functions with PAX5. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	NEUROD6;HOXC11;FOS;FLI1;MSX2;FOXK2;HIST2H3A;TCF3B;NR3C1
protein binding	COX4I1;ARID3A;ANKRD45;HNF1A;PIP4K2B;CX3CL1;EFCAB11;C2orf63;C1orf109
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	POU4F3;FOS;PATZ1;NR6A1;MITFB;ATOH1;TFAP2C;NFAT5;SOX2

PAX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX5.

mll_enl_human_protein; KMT2A; KMT2A; q8td98_human; lysU; cdkn1b_human_gene; DAXX

Lin, SG; Guo, CG; et al. CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:1815-1820(2015).

Zwollo, P; Ray, JC; et al. B cell signatures of BCWD-resistant and susceptible lines of rainbow trout: A shift towards more EBF-expressing progenitors and fewer mature B cells in resistant animals. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:1-12(2015).

B Cell Transcription Factors