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Pdgfa

  • Official Full Name

    platelet-derived growth factor alpha polypeptide

  • Overview

    The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene
  • Synonyms

    PDGFA; platelet-derived growth factor alpha polypeptide; PDGF1; PDGF-A; PDGF A-chain; platelet-derived growth factor alpha chain; Platelet-derived growth factor subunit A; PDGF subunit A; Platelet-derived growth factor A chain; PDGF-1; OTTHUMP00000199955; OTTHUMP00000199956; platelet-derived growth factor alpha isoform 2 preproprotein;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human cells
  • Mammalian Cell
  • Yeast
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • His|S
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDGFA-101H Active Recombinant Human PDGFA E.coli N/A
Human PDGFA-523H Active Recombinant Human PDGFA HEK293 N/A
Human PDGFA&PDGFB-17H Active Recombinant Human PDGF-AB E.coli N/A
Human PDGFA-375H Active Recombinant Human Platelet-derived Growth Factor AA HEK293 N/A
Human PDGFA-257HG Active GMP Recombinant Human PDGFA protein, Fc-tagged HEK293 Fc DNA sequence encoding Human PDGF-AA(NP_002598.4) was expressed with Fc tag at the C-terminal.
Human PDGFA-047H Recombinant Human PDGFA Protein HEK293 N/A
Human PDGFA-56H Recombinant Human PDGFAA Yeast N/A
Human PDGFA-1609H Recombinant Human PDGFA, GST-tagged E.coli GST C-179aa
Human PDGFA-174H Recombinant Human PDGFA protein, His/S-tagged E.coli His/S
Human PDGFA-54H Recombinant Human PDGFA, His-tagged E.coli His
Human PDGFA-57H Recombinant Human PDGFA protein E.coli N/A Ser87-Thr211
Human PDGFA-121H Recombinant Human PDGFA E.coli N/A
Human PDGFA-3337HCL Recombinant Human PDGFA 293 Cell Lysate HEK293 N/A
Human PDGFA-563H Recombinant Human PDGFA Protein (Ser87-Thr211), His-tagged Yeast His Ser87-Thr211
Human PDGFA-1608H Recombinant Human PDGFA protein, GST-tagged E. coli GST
Human PDGFA-093H Active Recombinant Human PDGFA Protein E. coli
Human PDGFA-2570H Recombinant Human PDGFA Protein, His-tagged E.coli N-His Ser87-Thr211
Human PDGFA-1392H Recombinant Human PDGFA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDGFA-2569H Recombinant Human PDGFA Protein, His-tagged E.coli N-His Ser87-Thr211
Human PDGFA-094H Active Recombinant Human PDGFA Protein E. coli
Human PDGFA-17HG Active Recombinant Human PDGFA Protein (Ser87-Thr211), GMP Grade, Animal-Free E.coli Ser87-Thr211
Human PDGFA-221H Active Recombinant Human PDGFA Protein E.coli
Human PDGFA-222H Active Recombinant Human PDGF-AB Protein E.coli
Human PDGFA-32H Recombinant Human PDGFA Protein E.coli
Human PDGFA-39HG Recombinant Human PDGFA Protein, GMP Grade, Animal-Free E.coli
Human PDGFA-44H Active Recombinant Human PDGFA Protein, Animal Free Human cells
Mouse Pdgfa-304M Active Recombinant Mouse Pdgfa E.coli N/A
Mouse Pdgfa-048M Recombinant Mouse Pdgfa Protein HEK293 N/A
Mouse Pdgfa-298M Recombinant Mouse Platelet Derived Growth Factor AA E.coli N/A
Mouse PDGFA-12567M Recombinant Mouse PDGFA Protein Mammalian Cell His
Mouse Pdgfa-175M Recombinant Mouse Pdgfa protein, His/S-tagged E.coli His/S
Mouse Pdgfa-564M Recombinant Mouse Pdgfa protein, His-tagged E.coli His Ala94~Asp194
Mouse Pdgfa-4755M Active Recombinant Mouse Pdgfa Protein E. coli
Mouse Pdgfa-4754M Active Recombinant Mouse Pdgfa Protein E. coli
Mouse PDGFA-514M Recombinant Mouse PDGFA protein(Ser87-Arg196), His-tagged Yeast N-His Ser87-Arg196
Mouse Pdgfa-317P Active Recombinant Mouse Pdgfaa Protein (125 aa) E.coli 125
Mouse PDGFA-6594M Recombinant Mouse PDGFA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PDGFA-223M Active Recombinant Mouse PDGFA Protein E.coli
Mouse Pdgfa-4756M Recombinant Mouse Pdgfa Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PDGFA-6594M-B Recombinant Mouse PDGFA Protein Pre-coupled Magnetic Beads HEK293
Rat Pdgfa-215R Active Recombinant Rat Pdgfa E.coli N/A
Rat Pdgfa&Pdgfb-216R Active Recombinant Rat Pdgfa&Pdgfb E.coli N/A
Rat Pdgfa-176R Recombinant Rat Pdgfa protein, His/S-tagged E.coli His/S
Rat PDGFA-4337R Recombinant Rat PDGFA Protein Mammalian Cell His
Rat Pdgfa-2732R Recombinant Rat Pdgfa protein, His & T7-tagged E.coli His/T7 Glu90~Glu190 (Accession # P28576)
Rat PDGFA-3997R Recombinant Rat PDGFA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Pdgfa-375R Recombinant Rat Pdgfa protein E.coli N/A 111
Rat PDGFA-940R Recombinant Rat PDGFA Protein (Ser87-Arg196), His-tagged Yeast His Ser87-Arg196
Rat Pdgfa-1930R Recombinant Rat Pdgfa Protein, His-tagged E.coli N-His Glu90-Glu190
Rat PDGFA-3997R-B Recombinant Rat PDGFA Protein Pre-coupled Magnetic Beads HEK293
Canine PDGFA-1044C Active Recombinant Canine PDGFA protein(Ser87-Arg196), hFc-tagged HEK293 N-hFc Ser87-Arg196
Canine PDGFA-923C Recombinant Canine PDGFA Protein (Ser87-Arg196), His-tagged Yeast His Ser87-Arg196
Chicken PDGFA-5879C Recombinant Chicken PDGFA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Pdgfa Related Articles
  • Pdgfa Related Research Area

Pdgfa involved in several pathways and played different roles in them. We selected most pathways Pdgfa participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pdgfa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwaySTK4;GADD45BA;MAP2K5;CACNB3;FGF22;LRRK2;MAPK12B;MAPK10;PLA2G4D
Ras signaling pathwayFGFR4;CALM2;PIK3CD;IGF1R;FGFR1;SHC4;GNG4;PLD1;KIT
Rap signaling pathwayPIK3CA;ACTB;FGF16;PRKD3;CALML5;HGF;AKT1;RAC1;PARD6B
Cytokine-cytokine receptor interactionKITLGA;PDGFRA;IFNB1;KITLGB;IL19;CSF3R;CD40;CXCR3.1;IFNA6
Phospholipase D signaling pathwayTSC2;GRM4;GRM2;MAP2K1;SHC2;MS4A2;PTGFR;PPAP2C;GRM7
PIK-Akt signaling pathwayIFNB1;IL6;GNB3;GNG2;COL27A1;AKT2;OSMR;FGF3;Itga10&Itgb1
Focal adhesionACTN4;ROCK2A;MYLPF;Reln;PDPK1B;MAPK8;RAF1A;ITGB1;ITGB7
Gap junctionDRD2B;PRKACBB;GNA11A;HRAS;DRD1B;PRKG2;TUBA2;PRKACG;EGFRA
Regulation of actin cytoskeletonPIP5K1AA;HRASB;PDGFAA;PIK3R3B;Fgf15;PAK7;PDGFC;ROCK2B;SSH3
HTLV-I infectionETS2;MAP3K14;WNT4;DVL1;POLE2;DVL3;MRAS;MAP2K4;FZD7
Pathways in cancerGNAS;PIK3R3;PTGER1;RELA;FGF19;ZBTB16;EPAS1;FGF17;WNT9A
Transcriptional misregulation in cancerTRAF1;HIST1H3I;HIST1H3D;ETV6;ATM;HOXA10;CDK14;MEN1;HIST1H3A
MicroRNAs in cancerMMP9;HRAS;TRP63;ERBB2;BMF;PDGFRB;ZFPM2;EP300;CDC25C
GliomaMAP2K2;CCND1;CALM3;NRAS;PIK3CB;MAPK1;IGF1;Pdgfa&Pdgfb;BRAF
Prostate cancerPDGFD;TGFA;CREB3L2;IGF1R;TRP53;CREB3L3;Pdgfa&Pdgfb;ERBB2;MAP4K1
MelanomaMITF;FGF8;NRAS;MET;Fgf15;FGF16;FGF6;MAP2K2;Pdgfa&Pdgfb
Choline metabolism in cancerDGKE;DGKA;WAS;MAPK8;HRAS;PDPK1;GPCPD1;PPAP2B;DGKG

Pdgfa has several biochemical functions, for example, collagen binding, growth factor activity, platelet-derived growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pdgfa itself. We selected most functions Pdgfa had, and list some proteins which have the same functions with Pdgfa. You can find most of the proteins on our site.

Function Related Protein
collagen bindingLRRC15;CCBE1;LUM;DDR1;GPR56;VWF;Pdgfa&Pdgfb;ITGA9;Itga10&Itgb1
growth factor activityEPGN;FGF1A;LEFTY2;PRL2C3;HBEGF;DKK1;CSF1B;MANF;TIMP1
platelet-derived growth factor bindingCOL1A1;PDGFRB;COL3A1;Pdgfa&Pdgfb;COL2A1;PDGFB;COL4A1;PDGFRA;COL1A2
platelet-derived growth factor receptor bindingPTPRJ;PDGFC;FIGF;ITGB3;PDGFRB;LYN;Pdgfa&Pdgfb;ITGA5;PDGFB
protein bindingCRMP1;PAK4;CDC26;PSTPIP1;RBM41;RAB3IP;MPG;IFI35;ZBTB5
protein heterodimerization activityTIRAP;NFYBA;CLNS1A;ADIPOR1;MYOG;SRY;TENM1;RRAGA;AGTR1
protein homodimerization activityIDE;MTHFD1L;ANXA6;DROSHA;ERBB4;FAM109B;PTS;CD247;BHLHE40

Pdgfa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pdgfa here. Most of them are supplied by our site. Hope this information will be useful for your research of Pdgfa.

PDGFRA; PDGFRB; PDGFB

Miller, JD; Benjamin, JT; et al. Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 298:L637-L645(2010).
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