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PDHB

  • Official Full Name

    pyruvate dehydrogenase (lipoamide) beta

  • Overview

    The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene.
  • Synonyms

    PDHB; pyruvate dehydrogenase (lipoamide) beta; pyruvate dehydrogenase E1 component subunit beta, mitochondrial; pyruvate dehydrogenase, E1 beta polypeptide; PDHBD; PHE1B; PDHE1-B; DKFZp564K0164;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bacillus subtilis
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • Bovine Heart
  • E. coli or Yeast
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDHB-135H Recombinant Human PDHB Protein, His-tagged E.coli His
Human PDHB-1614H Recombinant Human PDHB, GST-tagged E.coli GST 1-359aa
Human PDHB-1322HCL Recombinant Human PDHB cell lysate N/A
Human PDHB-4855H Recombinant Human PDHB Protein (Leu31-Asn341), N-His tagged E.coli N-His Leu31-Asn341
Mouse PDHB-12574M Recombinant Mouse PDHB Protein Mammalian Cell His
Mouse Pdhb-1976M Recombinant Mouse Pdhb protein, His-tagged E.coli His Gly65~Lys336 ((Accession # Q9D051)
Mouse PDHB-6600M Recombinant Mouse PDHB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PDHB-6600M-B Recombinant Mouse PDHB Protein Pre-coupled Magnetic Beads HEK293
Rat PDHB-4343R Recombinant Rat PDHB Protein Mammalian Cell His
Rat PDHB-4003R Recombinant Rat PDHB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PDHB-4003R-B Recombinant Rat PDHB Protein Pre-coupled Magnetic Beads HEK293
Bacillus subtilis PDHB-1497B Recombinant Bacillus subtilis PDHB protein, His-tagged E. coli or Yeast His
Bovine PDHB-1860B Native Bovine Pyruvate Dehydrogenase (lipoamide) Beta Bovine Heart N/A
Rhesus Macaque PDHB-3356R Recombinant Rhesus monkey PDHB Protein, His-tagged Mammalian Cell His
Rhesus Macaque PDHB-3174R Recombinant Rhesus Macaque PDHB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PDHB-3174R-B Recombinant Rhesus Macaque PDHB Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PDHB-12370Z Recombinant Zebrafish PDHB Mammalian Cell His
Chicken PDHB-4188C Recombinant Chicken PDHB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDHB Related Research Area

PDHB involved in several pathways and played different roles in them. We selected most pathways PDHB participated on our site, such as Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisALDH3B1;ADH7;DLDH;ALDH9A1;G6PC3;PKM2;AKR1A1B;ALDH9A1B;HK1
Citrate cycle (TCA cycle)PDHB;MDH1;OGDHA;PDHA1A;DLAT;PCK2;DLD;SUCLA2;ACO1
Pyruvate metabolismMPC1;PDHA1;PCXB;ALDH2.2;MDH1;PDK4;PKM;PKMB;PDHA2
Metabolic pathwaysALPI.2;RDH10B;POLR2F;UGT8A;PRPS1;FDFT1;NAGS;COX4I1;PLCB1
Carbon metabolismGPI1;GPI;ACADS;PHGDH;HK2;PGAM1B;PFKM;ENO2;PGK1
HIF- signaling pathwayMAP2K1;ALDOA;CAMK2G;PLCG1;PIK3CA;PIK3CB;EIF4E2;Trf;PDHB
Central carbon metabolism in cancerHK3;NTRK3;NTRK1;HK1;PIK3R3;SIRT3;MTOR;PGAM1;KIT

PDHB has several biochemical functions, for example, protein binding, contributes_to pyruvate dehydrogenase (NAD+) activity, pyruvate dehydrogenase (acetyl-transferring) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDHB itself. We selected most functions PDHB had, and list some proteins which have the same functions with PDHB. You can find most of the proteins on our site.

Function Related Protein
protein bindingVTA1;ITGAV;EIF4EBP2;MCM7;PLAU;COX4I2;MTA1;LRCH1;CCDC64B
contributes_to pyruvate dehydrogenase (NAD+) activityPDHB;DLAT;PDHX;DLD
pyruvate dehydrogenase (acetyl-transferring) activityPDHA1A;PDHA2;PDHA1;PDHA1B;PDHB
pyruvate dehydrogenase activityPDHB;PDHA1

PDHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDHB here. Most of them are supplied by our site. Hope this information will be useful for your research of PDHB.

DLAT; PDHA1; 7242199; GH1; MCC; IKBKE; BRF2; WRAP73; PFDN1; ITGB1; FCER1A; RCC1; ANXA7; AKT1

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