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PDK1

  • Official Full Name

    pyruvate dehydrogenase kinase, isozyme 1

  • Overview

    Phosphoinositide-dependent protein kinase 1 (PDK-1) plays a central role in many signal transduction pathways, activating AKT and the PKC isoenzyme p70S6 kinase and RSK. Through its effects on these kinases, PDK-1 is involved in the regulation of wide variety of process, including cell proliferation, differentiation and apoptosis.
  • Synonyms

    PDK1; pyruvate dehydrogenase kinase, isozyme 1; pyruvate dehydrogenase kinase, isoenzyme 1; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDK1-123H Recombinant Human Pyruvate dehydrogenase kinase, isozyme 1, His-tagged E.coli His
Human PDK1-30240TH Recombinant Human PDK1, His-tagged His 408 amino acids
Human PDK1-598H Recombinant Human PDK1 Mammalian Cell His
Human PDK1-904H Recombinant Human PDK1, His tagged Insect Cell His
Human PDK1-603HCL Recombinant Human PDK1 cell lysate Insect Cell N/A
Human PDK1-6460H Recombinant Human PDK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDK1-4857H Recombinant Human PDK1 Protein (Tyr233-Met430), N-His tagged E.coli N-His Tyr233-Met430
Human PDK1-824H Recombinant Human PDK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PDK1-1638H-B Recombinant Human PDK1 Protein Pre-coupled Magnetic Beads HEK293
Human PDK1-7254HF Active Recombinant Full Length Human PDK1 Protein, GST-tagged Insect (sf21) GST 1-436
Human PDK1-124H Active Recombinant Human PDK1 Protein, GST-tagged Insect cells GST
Human PDK1-1424HFL Recombinant Full Length Human PDK1 Protein, C-Flag-tagged Mammalian cells Flag
Human PDK1-1638H Recombinant Human PDK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PDK1-12583M Recombinant Mouse PDK1 Protein Mammalian Cell His
Mouse Pdk1-8026M Recombinant Mouse Pdk1 protein, His & T7-tagged E.coli His/T7 Val172~Pro399 (Accession # Q8BFP9)
Mouse PDK1-6607M-B Recombinant Mouse PDK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse PDK1-6607M Recombinant Mouse PDK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pdk1-4766M Recombinant Mouse Pdk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pdk1-2329M Recombinant Mouse Pdk1 protein, His-tagged Insect Cell His 27-434aa
Rat Pdk1-1932R Recombinant Rat Pdk1 Protein, His-tagged E.coli N-His Val172-Pro399
Chicken PDK1-3005C Recombinant Chicken PDK1 Mammalian Cell His
Kit-0672 PDK1 Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDK1 Related Articles
  • PDK1 Related Research Area
  • PDK1 Related Signal Pathway

PDK1 involved in several pathways and played different roles in them. We selected most pathways PDK1 participated on our site, such as HIF- signaling pathway, Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HIF- signaling pathwayPFKL;TCEB1;IL6;MAP2K1;AKT2;MAP2K2;CAMK2A;FLT1;HK1
Central carbon metabolism in cancerTRP53;MET;KIT;SLC1A5;PDHA2;GLS2;PIK3CA;PTEN;PKM2

PDK1 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK1 itself. We selected most functions PDK1 had, and list some proteins which have the same functions with PDK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingRFC4;ATAD3A;CDK9;ACTG1;DCLK2;UBE2D1;PIK3C2G;CDC6;KIF16B
protein bindingC1R;KANSL2;L3MBTL3;GFAP;ALKBH3;PPP1R16A;NOP56;EPB41L3;ISY1
protein kinase activityCSNK1E;MAPK14A;OXSR1A;CSNK2A2A;BSK146;INSRA;LRRK2;CLK2A;NEK10
pyruvate dehydrogenase (acetyl-transferring) kinase activityPDK2;PDK1;PDK4;PDK3

PDK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK1.

SGK3; PDHA1; RPS6KB1; PKN2; EPAS1; XRCC6; VWA8; CELF2; RIMS1; COG4; HMGN1; MYH1; COL4A5; PDK2

Dieni, CA; Storey, KB; et al. Protein kinase C in the wood frog, Rana sylvatica: reassessing the tissue-specific regulation of PKC isozymes during freezing. PEERJ 2:-(2014).
Hong, HJ; Kang, W; et al. Effects of resveratrol on the insulin signaling pathway of obese mice. JOURNAL OF VETERINARY SCIENCE 15:179-185(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is PDK1 associated with obesity? 04/13/2022

May play a role in the occurrence of obesity, and the current research conclusions still need to be further verified.

Is PDK1 related to the cardiovascular system? 03/12/2022

PDK1 is thought to be associated with the occurrence and progression of cardiovascular disease, and may affect the health of the cardiovascular system by regulating the glucose metabolism of cardiomyocytes and the activity of phosphatase. However, further research and validation are needed.

What signal pathways does PDK1 participate in and how does it regulate signals? 09/24/2021

Participates in a variety of signaling pathways, such as Akt and PKC, and affects the transmission and regulation of various signaling pathways by regulating the kinase activities of related receptors and enzymes.

In which tumors are PDK1 abnormally expressed? 09/17/2020

PDK1 has abnormal expression in a variety of tumors, such as breast cancer, pancreatic cancer, colorectal cancer, etc., and is one of the important markers of tumor occurrence and prognosis.

How does PDK1 regulate cell metabolism? 12/31/2019

The plays an important role in regulating cell metabolism and plays an important role in energy metabolism by regulating the phosphorylation state of various enzymes.

Can PDK1 be used as a target for the treatment of new diabetes? 01/15/2019

It has been identified as a potential therapeutic target for new diabetes, possibly by improving insulin signaling and glycogen synthesis, but further exploration is needed.

Customer Reviews (3)

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Reviews
07/22/2022

    PDK1 production process is strictly controlled and the quality of the product is guaranteed.

    08/08/2020

      Reproducibility of PDK1 is simply unrivaled, with identical results in every experiment or application, demonstrating its high stability and reliability.

      09/15/2019

        The catalytic activity of PDK1 is excellent, which can simplify complex chemical reactions and improve yields, and its scientific research value is self-evident.

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