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PENK

  • Official Full Name

    proenkephalin

  • Overview

    Met-and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
  • Synonyms

    Leu-enkephalin; Met-enkephalin; Met-enkephalin-Arg-Gly-Leu; Met-enkephalin-Arg-Phe; Methionine enkephalin; OGF; Opioid growth factor; PENK; PENK(114-133); PENK(143-183); PENK(237-258); PENK_HUMAN; PPA; Proenkephalin A; Proenkephalin; Proenkephalin-A; Synenkephalin; Met Enkephalin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PENK-177H Recombinant Human PENK, His-tagged HEK293 His
Human PENK-8008H Recombinant Human PENK protein, His & T7-tagged E.coli His/T7 Glu25~Phe267 (Accession # P01210)
Human PENK-3298HCL Recombinant Human PENK 293 Cell Lysate HEK293 N/A
Human PENK-2338H Recombinant Human PENK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PENK-1647H-B Recombinant Human PENK Protein Pre-coupled Magnetic Beads HEK293
Human PENK-1647H Recombinant Human PENK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PENK-1950HFL Recombinant Full Length Human PENK Protein, C-Flag-tagged Mammalian cells Flag
Human PENK-3226H Recombinant Human PENK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PENK-4863H Recombinant Human PENK Protein (Glu25-Ala133), N-His tagged E.coli N-His Glu25-Ala133
Human PENK-5909H Recombinant Human PENK Protein (Glu25-Phe267), C-His tagged Mammalian cells C-His Glu25-Phe267
Mouse PENK-12632M Recombinant Mouse PENK Protein Mammalian Cell His
Mouse Penk-4793M Recombinant Mouse Penk Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PENK-6634M-B Recombinant Mouse PENK Protein Pre-coupled Magnetic Beads HEK293
Mouse PENK-6634M Recombinant Mouse PENK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PENK-4375R Recombinant Rat PENK Protein Mammalian Cell His
Rat PENK-4035R-B Recombinant Rat PENK Protein Pre-coupled Magnetic Beads HEK293
Rat PENK-4035R Recombinant Rat PENK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PENK Related Articles

PENK involved in several pathways and played different roles in them. We selected most pathways PENK participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PENK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)PENKB;PPY;CCK;SSTR3;PENK;GPR4;GPR31B;ADRB2;ADORA2B
G alpha (i) signalling eventsDRD3;SSTR5;RLN3;APPB;OPN1MW;SST;OPN1LW1;RGS11;LPAR2B
GPCR downstream signalingOXGR1;CGA;EDN1;FPR-RS6;PYY;RASGRP2;OPN1MW;ANXA1C;PDE10A
GPCR ligand bindingINSL3;SCT;PTHLH;ADCYAP1B;TAS2R13;NPFF;KISS1;CYSLTR1;OXGR1
Peptide ligand-binding receptorsNMB;CCK;OXTRL;EDN3;XK;RLN3A;NPFF;INSL3;QRFPR
Signal TransductionCCRL2;SHARPIN;GPR55A;CHN2;SHRPRBCK1R;S1PR5B;GHRH;ACVR1C;SOX4A
Signaling by GPCRGPR18;OXER1;CCL19A.2;APLN;SCT;INSL5;GPR55;CD97;DCLRE1B

PENK has several biochemical functions, for example, neuropeptide hormone activity, opioid peptide activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PENK itself. We selected most functions PENK had, and list some proteins which have the same functions with PENK. You can find most of the proteins on our site.

Function Related Protein
neuropeptide hormone activityC12orf39;PENK;AGRP;UCN;NPPA;PRLH;NPFF;ADCYAP1;GAL
opioid peptide activityPNOC;PDYN;ZFP106;CDC42EP2;PENK
protein bindingPARP16;NDUFB9;DPP3;ZWINT;BTRC;TXNL4A;CRP;PHB2;ATXN1L

PENK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PENK here. Most of them are supplied by our site. Hope this information will be useful for your research of PENK.

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Subiran, N; Candenas, L; et al. Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide. FERTILITY AND STERILITY 98:617-U382(2012).
Hanrieder, J; Ljungdahl, A; et al. L-DOPA-induced Dyskinesia is Associated with Regional Increase of Striatal Dynorphin Peptides as Elucidated by Imaging Mass Spectrometry. MOLECULAR & CELLULAR PROTEOMICS 10:-(2011).
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