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PER1

Official Full Name

period homolog 1 (Drosophila)
Overview

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.
Synonyms

PER1; period homolog 1 (Drosophila); PER, period (Drosophila) homolog 1; period circadian protein homolog 1; RIGUI; Circadian clock protein PERIOD 1; Circadian clock protein PERIOD1; Circadian pacemaker protein RIGUI; hPER 1; hPER; hPER1; KIAA0482; MGC88021; PER 1; PER; PER1 protein; Period 1; Period drosophila homolog of; Period homolog 1; Period1; Period, drosophila, homolog of;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Source

E.coli
E.coli expression system
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PER1-1645H	Recombinant Human PER1, GST-tagged	E.coli	GST	1-341aa	$319 / 25ug
Human	PER1-1332HCL	Recombinant Human PER1 cell lysate		N/A		Inquiry
Human	PER1-1864H	Recombinant Human PER1 protein, GST-tagged	E.coli	GST	1-346 aa	$319 / 25ug
Human	PER1-1923H	Recombinant Human PER1 protein, His & T7-tagged	E.coli	His/T7	Ile208~Gln414 (Accession # O15534)	Inquiry
Human	PER1-2576H	Recombinant Human PER1 Protein, His-tagged	E.coli	N-His	Ile208-Gln414	Inquiry
Human	PER1-3730H	Recombinant Human PER1 protein, His-tagged	E.coli	His	1-341 aa	$319 / 25ug
Mouse	PER1-12635M	Recombinant Mouse PER1 Protein	Mammalian Cell	His		Inquiry
Mouse	PER1-6636M	Recombinant Mouse PER1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PER1-6636M-B	Recombinant Mouse PER1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PER1-4377R	Recombinant Rat PER1 Protein	Mammalian Cell	His		Inquiry
Rat	PER1-4037R-B	Recombinant Rat PER1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PER1-4037R	Recombinant Rat PER1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	RFL24629SF	Recombinant Full Length Saccharomyces Cerevisiae Protein Per1(Per1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (22-357)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PER1 Related Articles

PER1 involved in several pathways and played different roles in them. We selected most pathways PER1 participated on our site, such as Circadian rhythm, Circadian entrainment, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PER1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Circadian rhythm	BHLHE40;PRKAG2;PRKAA2;RORB;CSNK1E;RORA;ARNTL;CRY2;NPAS2
Circadian entrainment	GRIA4;CACNA1H;MAPK1;CAMK2B;PLCB3;PRKG2;MTNR1B;GNAI2;PRKCA
Herpes simplex infection	HCFC1A;EEF1DA;HLA-DMB;BF2;SRSF5A;FADD;IKBKB;JAK2B;IFNA3

PER1 has several biochemical functions, for example, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PER1 itself. We selected most functions PER1 had, and list some proteins which have the same functions with PER1. You can find most of the proteins on our site.

Function	Related Protein
E-box binding	ARNTL;TAL1;NEUROG2;GATA3;TFAP4;TWIST1;ZEB1;CLOCK;LMO2
RNA polymerase II core promoter proximal region sequence-specific DNA binding	NKX2;HHEX;ZNF253;MYF6;MLXIPL;ZSCAN21;CEBPB;GMEB2;ISL1
chromatin DNA binding	NOTCH1;EP300;SLAMF7;RELA;VAX2;MED1;APEX1;RUVBL2;H2AFY
kinase binding	DLG1;MIDN;SNAI1;TAX1BP1;SGOL1;PER1;CHP;JAKMIP1;LDHA
transcription factor activity, transcription factor binding	TP63;PER2;ASCL1B;LDB2B;TRP63;PER1;ASCL1;LDB1A;LDB2A
transcription factor binding	TRERF1;TFDP2;KCTD1;HYAL1;NKX3-1;PPARGC1B;DOT1L;SRY;Ar
ubiquitin protein ligase binding	DBT;HSPA1A;FZD8;ARRB2;CASP10;UBE2J1;HSPA9;TXNIP;HDAC6

PER1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PER1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PER1.

Cry1; CSNK1E; Csnk1e; TNS2; FAM65B; Csnk1d; GTSE1

Ait-Hmyed, O; Felder-Schmittbuhl, MP; et al. Mice lacking Period 1 and Period 2 circadian clock genes exhibit blue cone photoreceptor defects. EUROPEAN JOURNAL OF NEUROSCIENCE 37:1048-1060(2013).

LeSauter, J; Lambert, CM; et al. Antibodies for Assessing Circadian Clock Proteins in the Rodent Suprachiasmatic Nucleus. PLOS ONE 7:-(2012).