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PEX19

Official Full Name

peroxisomal biogenesis factor 19
Overview

This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants.
Synonyms

PEX19; peroxisomal biogenesis factor 19; peroxisomal farnesylated protein , PXF; D1S2223E; HK33; housekeeping gene; 33kD; PMP1; PMPI; PXMP1; peroxin-19; housekeeping gene, 33kD; 33 kDa housekeeping protein; peroxisomal farnesylated protein; PXF; FLJ55296;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Human
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|T7
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PEX19-1650H	Recombinant Human PEX19, GST-tagged	E.coli	GST	1-299aa	$319 / 25ug
Human	PEX19-2962H	Recombinant Human PEX19, His-tagged	E.coli	His		Inquiry
Human	PEX19-3637H	Recombinant Human PEX19, His-tagged	Human	His		Inquiry
Human	PEX19-27601TH	Recombinant Human PEX19, His-tagged	E.coli	His	296 amino acids	Inquiry
Human	PEX19-28143TH	Recombinant Human PEX19, His-tagged	E.coli	His		Inquiry
Human	PEX19-3289HCL	Recombinant Human PEX19 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PEX19-2003H	Recombinant Human PEX19 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	PEX19-12650M	Recombinant Mouse PEX19 Protein	Mammalian Cell	His		Inquiry
Mouse	Pex19-1693M	Recombinant Mouse Pex19 protein, His & T7-tagged	E.coli	His/T7	Ala2~Cys296 (Accession # Q8VCI5)	Inquiry
Mouse	Pex19-4798M	Recombinant Mouse Pex19 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	PEX19-6647M	Recombinant Mouse PEX19 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PEX19-6647M-B	Recombinant Mouse PEX19 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	PEX19-2318Z	Recombinant Zebrafish PEX19	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PEX19 involved in several pathways and played different roles in them. We selected most pathways PEX19 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEX19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Peroxisome	ACSL5;DECR2;PXMP2;PEX11B;SCP2A;SOD1;AGXTB;PEX5;ANI_1_2390104

PEX19 has several biochemical functions, for example, ATPase binding, peroxisome membrane class-1 targeting sequence binding, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEX19 itself. We selected most functions PEX19 had, and list some proteins which have the same functions with PEX19. You can find most of the proteins on our site.

Function	Related Protein
ATPase binding	PKD2;ATP6V0A2;FBL;FXYD3;PGR;ATP1B2;RALB;NKAIN1;EZR
peroxisome membrane class-1 targeting sequence binding
protein N-terminus binding	SMARCA4;RBPJ;EXOC4;VWF;PIAS3;MYO7A;MAU2;ERCC4;ACOX1
protein binding	ANKFY1;TARS;RASD1;SRSF3;KCNA5;MAP2;UBR1;TMEM79;GGPS1

PEX19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEX19 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEX19.

PEX3