PFDN5
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Official Full Name
prefoldin subunit 5
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Overview
This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
PFDN5; prefoldin subunit 5; prefoldin 5; MM 1; PFD5; 1190001O17Rik; 1700010A06Rik; c myc binding protein; c-myc binding protein MM 1; C-myc-binding protein Mm-1; D15Ertd697e; EIG 1; Eig1; MGC5329; MGC71907; MM1; Myc modulator 1; PFD5_HUMAN; myc modulator-1; c-myc binding protein; MM-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- N
- GST
- Involved Pathway
- Protein Function
- Interacting Protein
PFDN5 involved in several pathways and played different roles in them. We selected most pathways PFDN5 participated on our site, such as Chaperonin-mediated protein folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFDN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chaperonin-mediated protein folding | VBP1;PFDN5;CCT4;NOP56;FBXW5;CCT5;CCT3;PFDN6;FBXW2 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | CCT6A;PFDN5;PFDN4;PFDN2;CCT3;PFDN1;VBP1;CCT2;TCP1 |
| Metabolism of proteins | CST3;RING1;NEU3;NAPAA;TRAPPC6A;SSPO;GAS6;DDOST;EXOC1 |
| Prefoldin mediated transfer of substrate to CCT/TriC | PFDN5;CCT7;PFDN4;PFDN2;PFDN6;CCT6A;PFDN1;VBP1 |
| Protein folding | PFDN1;FKBP9;FBXW5;FBXW9;TBCD;TBCB;FBXL5;PFDN6;PFDN4 |
PFDN5 has several biochemical functions, for example, protein binding, transcription corepressor activity, unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFDN5 itself. We selected most functions PFDN5 had, and list some proteins which have the same functions with PFDN5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SLC3A2;XPO5;ALAS2;RCOR3;PIK3R3;PACS1;IGF1;ANKRD1;SCARF1 |
| transcription corepressor activity | NR0B1;BATF3;CSDA;E4F1;BCL11A;TFCP2L1;PROX1;TBL1Y;PBXIP1 |
| unfolded protein binding | CCT6A;HSPD1;TBCA;GRPEL2;H2-KE2;DNAJA2L;CDC37L1;CALRL2;TMEM67 |
PFDN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFDN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFDN5.
vIRF-3; CALCOCO2; GLRX3; PSME3; IKZF3
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