PFDN6
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Official Full Name
prefoldin subunit 6
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Overview
PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and;beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin;containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 (PubMed 10209023)). -
Synonyms
PFDN6; prefoldin subunit 6; HKE2, HLA class II region expressed gene KE2 , prefoldin 6; H2 KE2; KE 2; PFD6; H2KE2; HKE2; HLA class II region expressed gene KE2; KE2; KE2 protein; PFD6_HUMAN; Protein Ke2; prefoldin 6; KE-2; H2-KE2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PFDN6 involved in several pathways and played different roles in them. We selected most pathways PFDN6 participated on our site, such as Chaperonin-mediated protein folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFDN6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chaperonin-mediated protein folding | FBXW4;CCT2;FBXL5;CCT8;TUBB4B;CCT4;CCT6A;VBP1;CCT3 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | PFDN1;TUBB4A;CCT7;TUBA1B;CCT3;CCT6A;CCT5;PFDN2;TUBB4B |
| Metabolism of proteins | SAMM50;DPAGT1;LMAN2;MPDU1B;PHC3;TRAPPC3;FKBP9;CCDC59;EXOC5 |
| Prefoldin mediated transfer of substrate to CCT/TriC | PFDN5;VBP1;PFDN4;CCT6A;PFDN1;PFDN6;CCT7;PFDN2 |
| Protein folding | FBXL5;FBXW5;PFDN1;VBP1;TBCC;FBXW9;CCT7;PFDN2;SERPINA7 |
PFDN6 has several biochemical functions, for example, chaperone binding, unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFDN6 itself. We selected most functions PFDN6 had, and list some proteins which have the same functions with PFDN6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chaperone binding | FGB;CP;SYVN1;CTSC;UBL4A;TBCA;ATP1A2;TP53;SERPINA7 |
| unfolded protein binding | PFDN1;DNAJA2;CCT6A;HSPA5;HSPA6;HSP90AA1;HSP104;CCT4;TOR1A |
PFDN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFDN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFDN6.
PRPF4; Tubb4b; MDM2; TUBA3E; MAP3K3; WRAP73; SPATA2; B4GALT2; Pfdn2; PPP6R2; POLR1A; PPP1CC; Ruvbl1; Vbp1; PPP2CB; MAPK7; HDAC1; Isy1; Wdr61; POLR3E
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