PFN1
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Official Full Name
profilin 1
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Synonyms
PFN1; profilin 1; profilin-1; profilin I;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- N/A
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- PFN1 Related Research Area
PFN1 involved in several pathways and played different roles in them. We selected most pathways PFN1 participated on our site, such as Rap signaling pathway, Regulation of actin cytoskeleton, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | KLK1B4;P2RY1;ANGPT4;Pdgfa&Pdgfb;PDGFRB;FGF14;VAV2;ITGB2L;PARD3 |
| Regulation of actin cytoskeleton | FGF10A;ARHGEF6;SCINLB;BRK1;EZRB;PIP5K1A;MLCK2;FGF6A;FN1A |
| Shigellosis | ACTB;MAD2L2;VCL;ELMO2;ITGA5;MAPK12;RELA;NFKB1;RIPK2 |
| Salmonella infection | FOS;MYD88;FLNC;RHOGC;MYH10;ACTB1;DYNC1LI2;CD14;PFN3 |
PFN1 has several biochemical functions, for example, Rho GTPase binding, actin binding, actin monomer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFN1 itself. We selected most functions PFN1 had, and list some proteins which have the same functions with PFN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho GTPase binding | FMNL2;DIAP1;DOCK10;ROCK2;DIAP3;AKAP13;ECT2;ANTXR2A;ROCK2B |
| actin binding | VILL;SMYHC1;CAPG;WASF3B;PACRG;GC;FHL3;TBCCD1;PFN1 |
| actin monomer binding | LIMA1;PFN1;ABL1;MYL2;COBL;COBLL1;MKL1;LMOD3;PFN2 |
| adenyl-nucleotide exchange factor activity | GRPEL1;PFN1;HSPBP1;PFN2;SIL1;GRPEL2 |
| phosphatidylinositol-4,5-bisphosphate binding | TWF2;ANXA8;STXBP6L;ACTN2;SCIN;ADAP2;FAM123A;PFN1;RS1 |
| poly(A) RNA binding | FNDC3A;FYTTD1;STAU2;EXOSC10;EIF5;RBMX;MYO5A;SRPK1;MACF1 |
| proline-rich region binding | RABAC1;PFN1;ITSN1;FAM59A;TCERG1;APBB1;PRPF40A;ABI2;NEDD4 |
| protein binding | DPPA4;TRPC2;DRD4;PRSS21;ATRX;MYLK2;ZBTB48;POLE4;TMEM174 |
PFN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFN1.
Wasl; WASF1; SRPK1; Diaph1; YWHAZ; Bles03; Csnk1e; Akap12; ZNF16; ACTB; TLE1; RAD51; UNC119; CRMP1; tdh; RIF1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, PFN1 is involved in processes such as endocytosis, cytokinesis, and cell signaling, highlighting its importance in various cellular functions.
Research on targeting PFN1 in cancer therapy is ongoing, and there are clinical trials exploring potential drugs that could inhibit PFN1 activity to impede cancer cell metastasis.
PFN1 has been found to promote cancer cell migration and invasion, suggesting its role in cancer metastasis, making it a potential target for cancer therapy.
Yes, researchers are exploring the potential of developing drugs that target PFN1 to modulate its activity, especially in the context of cancer metastasis and neurodegenerative disorders.
PFN1 regulates cell motility and migration by controlling the dynamics of actin filaments, essential components of the cell's cytoskeleton involved in cell movement.
Customer Reviews (3)
Write a reviewThe manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.
Their excellent technical support, commitment to scientific collaboration, and efficient supply chain management greatly contribute to the success and productivity of my research.
One of the key advantages of using PFN1 protein in trials is its high quality.
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