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PGC

  • Official Full Name

    progastricsin (pepsinogen C)

  • Overview

    This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
  • Synonyms

    progastricsin (pepsinogen C); PEPC; PGII; FLJ99563; Gastricsin; PEPC_HUMAN; Pepsinogen C; PGC; Progastricsin; Pepsinogen II;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human
  • Human Cell
  • Human Gastric Mucosa
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PGC-1028H Active Recombinant Human Pepsinogen I Protein E.coli N/A
Human PGC-142H Recombinant Human PGC Protein, His-tagged E.coli His Val61~Ala388
Human PGC-3238H Recombinant Human PGC protein, His-tagged HEK293 His Met1-Ala388
Human PGC-1663H Recombinant Human PGC, His-tagged E.coli His 1-388aa
Human PGC-446H Recombinant Human PGC Protein, His-tagged E.coli His
Human PGC-2169HCL Recombinant Human PGC cell lysate Human Cell N/A
Human PGC-132H Native Human Pepsinogen II Human Gastric Mucosa N/A
Human PGC-0041H Recombinant Human PGC Protein HEK293 cells
Human PGC-2342H Recombinant Human PGC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PGC-8318H Native Human PGC Human N/A
Human PGC-1315H Recombinant Human PGC Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PGC-4879H Recombinant Human PGC Protein (Met1-Ala388), C-His tagged Mammalian cells C-His Met1-Ala388
Human PGC-023H Recombinant Human PGC protein, His-tagged E.coli His 379 aa
Mouse PGC-12681M Recombinant Mouse PGC Protein Mammalian Cell His
Mouse Pgc-143M Recombinant Mouse Pgc Protein, His/GST-tagged E.coli His/GST Ala17~Val392
Mouse Pgc-438M Recombinant Mouse Pgc Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse PGC-6662M Recombinant Mouse PGC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PGC-6662M-B Recombinant Mouse PGC Protein Pre-coupled Magnetic Beads HEK293
Rat Pgc-144R Recombinant Rat Pgc Protein, His-tagged E.coli His Ser17~Val392
Rat PGC-4404R Recombinant Rat PGC Protein Mammalian Cell His
Rat Pgc-2538R Recombinant Rat Pgc protein, His-tagged HEK293 His Met1-Val392
Rat PGC-1705RCL Recombinant Rat PGC cell lysate Human Cell N/A
Rat PGC-4064R Recombinant Rat PGC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PGC-4064R-B Recombinant Rat PGC Protein Pre-coupled Magnetic Beads HEK293
Chicken PGC-6440C Recombinant Chicken PGC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PGC Related Articles

PGC involved in several pathways and played different roles in them. We selected most pathways PGC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PGC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

PGC has several biochemical functions, for example, aspartic-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PGC itself. We selected most functions PGC had, and list some proteins which have the same functions with PGC. You can find most of the proteins on our site.

Function Related Protein
aspartic-type endopeptidase activitySPPL2;BACE2;PSEN2;PGA;CNTNAP5A;ANK2B;REN;Ren1;PSEN1

PGC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGC here. Most of them are supplied by our site. Hope this information will be useful for your research of PGC.

Anugraham, M; Everest-Dass, AV; et al. A platform for the structural characterization of glycans enzymatically released from glycosphingolipids extracted from tissue and cells. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 29:545-561(2015).
Michael, C; Rizzi, AM; et al. Quantitative isomer-specific N-glycan fingerprinting using isotope coded labeling and high performance liquid chromatography-electrospray ionization-mass spectrometry with graphitic carbon stationary phase. JOURNAL OF CHROMATOGRAPHY A 1383:88-95(2015).
  • Q&As
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