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PGR

  • Official Full Name

    progesterone receptor

  • Overview

    This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]
  • Synonyms

    PGR; progesterone receptor; PR; NR3C3; nuclear receptor subfamily 3 group C member 3;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Dog
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PGR-182H Recombinant Human Progesterone Receptor E.coli N/A
Human PGR-29707TH Recombinant Human PGR E.coli N/A
Human PGR-106H Recombinant Human Progesterone receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
Human PGR-228H Recombinant Human PGR, StrepII-tagged Human Cell Strep II 412-526, 115 a.a.
Human PGR-20H Recombinant Human PGR protein, GST-tagged Insect Cell GST
Human PGR-183H Recombinant Human PGR protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PGR-6753H Recombinant Human PGR protein, His & T7-tagged E.coli His/T7 Ala412~Leu562 (Accession # P06401)
Human PGR-3881H Recombinant Human PGR protein, His-tagged E.coli His 1-301 aa
Human PGR-5861H Recombinant Human PGR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PGR-7204HFL Recombinant Full Length Human PGR protein, Flag-tagged Mamanlian cells Flag
Mouse Pgr-4828M Recombinant Mouse Pgr Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PGR-4410R Recombinant Rat PGR Protein Mammalian Cell His
Rat Pgr-6754R Recombinant Rat Pgr protein, His & T7-tagged E.coli His/T7 Gln672~Thr790 (Accession # Q63449)
Rat PGR-4070R Recombinant Rat PGR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PGR-4070R-B Recombinant Rat PGR Protein Pre-coupled Magnetic Beads HEK293
Dog PGR-1182D Recombinant Dog PGR Protein, His&GST-tagged E.coli N-His&GST Gln685-Ile919
Rhesus Macaque PGR-3395R Recombinant Rhesus monkey PGR Protein, His-tagged Mammalian Cell His
Rhesus Macaque PGR-3213R Recombinant Rhesus Macaque PGR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PGR-3213R-B Recombinant Rhesus Macaque PGR Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PGR-7617Z Recombinant Zebrafish PGR Mammalian Cell His
Chicken PGR-6814C Recombinant Chicken PGR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PGR Related Articles
  • PGR Related Research Area

PGR involved in several pathways and played different roles in them. We selected most pathways PGR participated on our site, such as Oocyte meiosis, Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oocyte meiosisANAPC5;CALM2A;IGF1RA;CALM1;MOS;PPP2R1A;RPS6KA3;CDC23;CALM3B
Progesterone-mediated oocyte maturationINS1;MAPK9;PIK3R3A;BUB1;MAPK11;CDH1-A;SPDYB;AKT2L;SPDYA

PGR has several biochemical functions, for example, ATPase binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PGR itself. We selected most functions PGR had, and list some proteins which have the same functions with PGR. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingNSFL1C;SNX10;SDF2L1;ABCA1;SELS;USP25;FXYD4;ATPIF1;ESR1
DNA bindingHIF3A;ZNF212;ZNF48;HOXB1B;TCF25;DNASE1L2;ZNF239;SOX1B;HIST1H3A
RNA polymerase II core promoter proximal region sequence-specific DNA bindingCLOCK;NCOA2;SMAD2;FOSL2;SRF;IFI203;SKIL;HOXA7;TFAM
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingNR2F6B;NR1I2;NR4A2B;ESRRA;VDRA;RORAA;NR5A1A;NR2F1B;PPARDB
enzyme bindingCYP2A6;YWHAE;SCN5A;XRCC1;LDB2;BCHE;C2orf56;IL6R;SUPT5H
protein bindingNAPG;COPS7B;LRRK1;HSPA1B;PPARGC1A;USP47;PGM1;TPP2;ACTA1
receptor bindingAPLN;CXADR;PTK2AA;MLN;MSTN;NUDT7;NRG2A;ANGPTL2;WNT2BB
steroid bindingESR1;Ar;NR3C2;ESRRB;PGRMC1;CYP3A4;SULT1E1;HSD17B10;ESR2A
steroid hormone receptor activityNR2F6B;NR1D4B;NR6A1;PAQR7A;NR0B2A;NR1D2A;THRAA;RORAB;PAQR8
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingPGR;SREBF1;ESRRA;NPAS4;PLAG1;TP73;HOXA5;MEF2C;MEIS1
zinc ion bindingCRIP3;ZDHHC5A;ZMYM5;FTR14;PDLIM3;ZDHHC20A;HLTF;ISL2A;TCEA2

PGR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGR here. Most of them are supplied by our site. Hope this information will be useful for your research of PGR.

CUEDC2; STAT3; SP1; r_5020_promegestone; PRMT2; JDP2; SMARCD1

Tosovic, A; Bondeson, AG; et al. T3 levels in relation to prognostic factors in breast cancer: a population-based prospective cohort study. BMC CANCER 14:-(2014).
Yardley, DA; Tripathy, D; et al. Long-term survivor characteristics in HER2-positive metastatic breast cancer from registHER. BRITISH JOURNAL OF CANCER 110:2756-2764(2014).
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