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PHF21A

Official Full Name

PHD finger protein 21A
Overview

The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Synonyms

PHF21A; PHD finger protein 21A; BHC80; BM-006; BHC80a; BRAF35/HDAC2 complex (80 kDa); BRAF35-HDAC complex protein BHC80;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PHF21A-3230HCL	Recombinant Human PHF21A 293 Cell Lysate	HEK293	N/A	Inquiry
Rhesus Macaque	PHF21A-3407R	Recombinant Rhesus monkey PHF21A Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	PHF21A-3225R	Recombinant Rhesus Macaque PHF21A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	PHF21A-3225R-B	Recombinant Rhesus Macaque PHF21A Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Chicken	PHF21A-4440C	Recombinant Chicken PHF21A	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PHF21A Related Articles

PHF21A involved in several pathways and played different roles in them. We selected most pathways PHF21A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF21A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	DNMT3A;SMYD2A;MSL1;ELP2;SETD3;SAP30L;SMARCE1;PADI3;TAF6L
Chromatin organization	SMARCB1A;MTA2;PHF17;BRD8;KDM4B;KDM1B;PADI1;RBBP4;KDM5B
Factors involved in megakaryocyte development and platelet production	ZFPM1;H3F3B.1;KIF2A;KIF5B;HBE1;KLC3;KIF15;DOCK1;GATA1
HDACs deacetylate histones	SUDS3;ARID4A;MBD3B;MTA1;SAP30;MTA3;SAP30L;MTA2;GATAD2A
Hemostasis	F3B;APOA1B;BA1;KCNMB1;F9A;PIK3R6;CEACAM8;KIFAP3;SH2B3

PHF21A has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF21A itself. We selected most functions PHF21A had, and list some proteins which have the same functions with PHF21A. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II regulatory region sequence-specific DNA binding	CDX1B;DLX2;ZNF548;RORA;ALX1;ZFP39;ELF5;IRF2;KLF12
chromatin binding	MED12;UBE2T;EGR2;Ar;STAG1;MEIS1;SOX14;HDAC5;NEUROG1
histone binding	HIST1H4N;BAZ2A;HJURP;SET;NCAPD3;HIST4H4;SART3;ASF1B;PHF21A
protein binding	VPS35;MORN4;PIAS4;TTC23L;MAGEH1;MARCKSL1;ZFP161;IMPA2;BAG5
transcription cofactor activity	NMI;SND1;CREB1;MED17;ANKRA2;IRF3;NFKBIZ;KAT2B;ZFP865
zinc ion binding	CREBBP;NEURL1AA;TRIM55A;ADAMTS15A;PHF13;PHRF1;ADH1;MT1A;SRSF7A

PHF21A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF21A here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF21A.

NUP62; TRAF1; FHL3; ZYX; KRT40; BANP; HDAC2

Montgomery, ND; Turcott, CM; et al. A 137-kb deletion within the Potocki-Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 161A:198-202(2013).

Kim, HG; Kim, HT; et al. Translocations Disrupting PHF21A in the Potocki-Shaffer-Syndrome Region Are Associated with Intellectual Disability and Craniofacial Anomalies. AMERICAN JOURNAL OF HUMAN GENETICS 91:56-72(2012).