PIK3C2B
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Official Full Name
phosphoinositide-3-kinase, class 2, beta polypeptide
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Overview
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. -
Synonyms
PIK3C2B; phosphoinositide-3-kinase, class 2, beta polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; C2 PI3K; PI3K C2beta; PI3K-C2beta; PI3K-C2-beta; PTDINS-3-kinase C2 beta; ptdIns-3-kinase C2 subunit beta; phosphoi;
- Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293T
- Insect Cell
- Sf9 Insect Cell
- GST
- His
- His|T7
- Myc
- DDK
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PIK3C2B-164H | Active Recombinant Human PIK3C2B protein, GST-tagged | Insect Cell | GST |
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| Human | PIK3C2B-1716H | Recombinant Human PIK3C2B, His-tagged | E.coli | His | 1-350aa | |
| Human | PIK3C2B-118H | Recombinant Human PIK3C2B, GST-tagged | Sf9 Insect Cell | GST |
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| Human | PIK3C2B-1871H | Recombinant Human PIK3C2B protein, GST-tagged | E.coli | GST | 1-350 aa | |
| Mouse | Pik3c2b-4862M | Recombinant Mouse Pik3c2b Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | Pik3c2b-1722R | Recombinant Rat Pik3c2b protein, His & T7-tagged | E.coli | His/T7 | Ser790~Leu1025 (Accession # D3ZVF3) |
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- Involved Pathway
- Protein Function
- Interacting Protein
- PIK3C2B Related Research Area
PIK3C2B involved in several pathways and played different roles in them. We selected most pathways PIK3C2B participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3C2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PLCG2;PLCH2;INPP4A;ITPKB;ITPKC;PTENB;PLCD1A;INPP5B;PLCD1 |
| Metabolic pathways | PFKL;SORD;CKB;SMPD1;HSD17B10;CYP11B2;PNLIP;B4GALT2;NOS2A |
| Phosphatidylinositol signaling system | OCRL;PLCE1;PIK3R1;PIP5K1B;CALM3A;PRKCB;CALM1;PRKCBB;CALML3 |
PIK3C2B has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3C2B itself. We selected most functions PIK3C2B had, and list some proteins which have the same functions with PIK3C2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-3-kinase activity | PIK3CD;PIK3CB;ATM;PIK3C2B;PIK3CA;PIK3R3;PIK3CG;PIK3C3;PIK3C2G |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | PIK3C2B;PIK3CD;PIK3C2G;PIK3CB;PIK3CG;PIK3C2A;PIK3CA |
| ATP binding | CCT6A;ERBB4;RAD54L;TAP1;ROCK2A;ULK4;FLT4;NLK;PSTK |
| lipid kinase activity | PIK3C2B;DGKZ;TAE1 |
| phosphatidylinositol binding | TUB;ZCCHC2;SNX25;PLD1;ITPR3;SEPT12;HIP1R;SNX10A;ESYT2 |
| protein binding | TNFRSF1A;DYNC1I1;PSKH1;ITM2A;LANCL2;CSPG5;TRMT12;CCDC148;TCAP |
PIK3C2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3C2B here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3C2B.
EGFR; TRIM27; GRB2; ERBB2; PDGFRB; NCK1
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