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PIK3R1

  • Official Full Name

    phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

  • Overview

    Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The;enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the;85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin,;and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in;four transcript variants encoding different isoforms.
  • Synonyms

    PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphati;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Mouse, Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect cells
  • Leishmania Tarentolae
  • Mammalian Cell
  • Sf9 Insect Cell
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIK3R1&PIK3CD-157H Active Recombinant Human PIK3R1/PIK3CD protein, His-tagged Insect Cell His
Human PIK3R1&Pik3ca-155H Active Recombinant Human PIK3CA and Mouse Pik3ca protein, His-tagged Insect Cell His
Human PIK3R1-29688TH Recombinant Human Human PIK3CA, His-tagged His
Human PIK3R1-31767TH Recombinant Human Human PIK3CB, His-tagged His
Human PIK3R1-31096TH Recombinant Human Human PIK3CB, His-tagged His
Human PIK3CA/PIK3R1-641H Recombinant Human PIK3CA/PIK3R1 Insect Cell N/A
Human PIK3R1-4864H Recombinant Human Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha), His-tagged Sf9 Insect Cell His
Human PIK3R1-4934H Recombinant Human PIK3R1 Protein, His-tagged Insect cells His
Human PIK3CA/PIK3R1-631H Recombinant Human PIK3CA/PIK3R1, FLAG-tagged Sf9 Insect Cell Flag
Human PIK3CA/PIK3R1-389H Recombinant Human PIK3CA/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Human PIK3R1-29588TH Recombinant Human PIK3R1, His-tagged His
Human PIK3CB/PIK3R1-632H Recombinant Human PIK3CB/PIK3R1, FLAG-tagged Sf9 Insect Cell Flag
Human PIK3CB/PIK3R1-391H Recombinant Human PIK3CB/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Human PIK3R1-1079H Recombinant Human PIK3R1, His-tagged Sf9 Insect Cell His Full Length
Human PIK3R1-315H Recombinant Human PIK3R1 protein, His/MBP-tagged E.coli His/MBP 1-110 aa
Human PIK3R1-316H Recombinant Human PIK3R2 protein, His/MBP-tagged E.coli His/MBP 296-397 aa
Human PIK3R1-3185HCL Recombinant Human PIK3R1 293 Cell Lysate HEK293 N/A
Human PIK3R1-4904H Recombinant Human PIK3R1 Protein (Trp624-Val718), N-His tagged E.coli N-His Trp624-Val718
Human PIK3R1-2925H Recombinant Human PIK3R1 protein, His-tagged E.coli His 319-372 aa
Human PIK3R1-670H Recombinant Human PIK3R1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PIK3R1-2931H Recombinant Human PIK3R1 Protein E.coli Tag Free
Human PIK3R1-4903H Recombinant Human PIK3R1 Protein (Trp624-Val718), C-His tagged E.coli C-His Trp624-Val718
Mouse Pik3r1-4865M Recombinant Mouse Pik3r1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PIK3R1-4463R Recombinant Rat PIK3R1 Protein Mammalian Cell His
Rat PIK3R1-4123R Recombinant Rat PIK3R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PIK3R1-4123R-B Recombinant Rat PIK3R1 Protein Pre-coupled Magnetic Beads HEK293
Bovine PIK3R1-05B Recombinant Bovine PIK3R1 Leishmania Tarentolae N/A
Bovine PIK3R1-06B Recombinant Bovine PIK3R1 Sf9 Insect Cell N/A
Mouse, Human Pik3ca/PIK3R1-390H Recombinant Mouse and Human Pik3ca/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Rhesus Macaque PIK3R1-3434R Recombinant Rhesus monkey PIK3R1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PIK3R1-3252R Recombinant Rhesus Macaque PIK3R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PIK3R1-3252R-B Recombinant Rhesus Macaque PIK3R1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PIK3R1-8346Z Recombinant Zebrafish PIK3R1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PIK3R1 Related Articles
  • PIK3R1 Related Research Area
  • PIK3R1 Related Signal Pathway

PIK3R1 involved in several pathways and played different roles in them. We selected most pathways PIK3R1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwaySHC1;MAPK8;NRG2B;NRG1;CAMK2D1;AKT3A;AKT1;HRAS;EREG
Ras signaling pathwayFGF20;GNG11;PAK7;PLA2G10;PAK6;ETS1;RAPGEF5;PIK3CA;MAPK8
Rap signaling pathwayFgf15;FIGF;GNAI2;Kitl;LPAR3;FGF3;BRAF;RAC1;RAC3
cGMP-PKG signaling pathwayGATA4;PPP3R1;NFATC2;CALML3;NFATC3;TRPC6;PPP1CA;CALM1;PLCB2
cAMP signaling pathwayTSHR;PIK3CG;GRIN2D;ATP1A3;MAPK3;AMH;GNAS;CAMK2D;GRIA4
Chemokine signaling pathwayCXCL12;GRB2;CCL16;CCL8;CCL7;GNG12;CCL13;ITK;GRK1
HIF- signaling pathwayPRKCA;NOS3;IGF1R;MKNK2;ANGPT4;TEK;PDHA2;RBX1;PFKFB3
FoxO signaling pathwaySGK3;IL7R;CDKN1BB;PIK3R1;GRB2;Fasl;PLK1;GABARAPA;FOXO1A
Phosphatidylinositol signaling systemINPP4B;CALML3;CALM3A;PI4KA;PIP4K2AA;PLCD1A;PLCD1B;PIK3R2;PTENA
Sphingolipid signaling pathwayPIK3R5;S1PR5;MAPK12;GAB2;PPP2R2C;GNAQ;AKT2;MAPK13;NFKB1
Phospholipase D signaling pathwayPLCB4;AKT2;PLD2;SYK;AVPR1A;SPHK1;HRAS;GAB1;GRM8
mTOR signaling pathwayEIF4BB;STRADA;DDIT4;RPTOR;PIK3R1;PRKCB;EIF4BA;INSB;ULK1
PIK-Akt signaling pathwayTSC1;PPP2R5D;LAMB1;RAC1;NR4A1;FGF20;IRS1;PDGFRB;ITGB1
AMPK signaling pathwayRPS6KB1;RHEB;STRADB;CPT1C;RAB2A;Scd1;SCD5;PPP2R1B;IGF1
ApoptosisCASP9;PLEC;OCLN;Fasl;STK26;IRAK2;BIRC3;HIST1H1E;MAP3K14
Adrenergic signaling in cardiomyocytesCACNG3;CREB3L3A;ADRB1;PLCB3;TPM1;GNAI2;AGTR1A;AKT2L;GNA11A
VEGF signaling pathwayPLA2G4A;MAPK13;RAC3A;AKT1;MAPK11;PPP3CCA;RAF1;PTK2;PPP3R1
Osteoclast differentiationMAPK11;FCGR3A;PIK3R1;FCGR3B;IFNGR2;IKBKB;FOSL2;BTK;TREM2
Focal adhesionPGF;PIK3CA;RHOA;COL27A1;RAC3B;PPP1R12A;SRMS;CDC42;COL6A2
Signaling pathways regulating pluripotency of stem cellsONECUT1;ZFHX3;FZD5;PIK3R1;PCGF1;ZIC3;PIK3CB;FGFR1;KLF4
Platelet activationRAP1B;MYLK;ITGB1;MAPK13;FCGR2A;GUCY1B3;PRKG2;FGB;AKT1
Toll-like receptor signaling pathwayMAP2K4;RIPK1L;SPP1;AKT2L;RAC1;IFNA4;CCL3;CXCL9;TBK1
Jak-STAT signaling pathwayPIK3R5;IL10RA;PTPN11A;CCND3;IL9R;BCL2;SOCS3;IL28A;SOCS1A
Natural killer cell mediated cytotoxicityNRAS;KIR2DS2;KIR3DL1;MAP2K1;PPP3R2;LCK;FAS;ICAM2;TNFRSF10A
T cell receptor signaling pathwaySLA1;PPP3R1;PAK7;IFNG;PTPN6;MAP2K2;ICOS;CD3D;PIK3CG
B cell receptor signaling pathwayMAP2K1;DUSP6;RAC2;PDK2;CD19;ITK;GSK3AB;CR2;NEDD9
Fc epsilon RI signaling pathwayFCER1G;AKT1;RAC2;PIK3CB;MAPK1;HRAS;MAPK13;PIK3R2;GRB2
Fc gamma R-mediated phagocytosisPIK3CG;LIMK2;FCGR2B;VAV1;AMPH;FCGR1;PTPRC;RPS6KB2;WASF2
TNF signaling pathwayCX3CL1;LTA;TRAF2;MMP3;TNFRSF1B;MAPK1;PIK3CD;ITCH;MAGI2
Leukocyte transendothelial migrationMYL9;GNAI1;MMP9;MYLPF;ROCK1;NOX3;Itgam&Itgb2;F11R;TXK
Neurotrophin signaling pathwayCDC42;NFKB1;BDNF;PRKCD;PIK3R1;GSK3B;CALM2;FASLG;RPS6KA6
Cholinergic synapsePLCB4;GNG11;FOS;PIK3R2;SLC5A7;GNG10;ACHE;MAP2K1;PIK3R5
Inflammatory mediator regulation of TRP channelsIL1R1;CYP2C70;PIK3CB;CYP2C39;TRPM8;ASIC4;ACCN3;MAPK9;MAPK10
Regulation of actin cytoskeletonINSRR;FGF12;SSH1;BRAF;PAK3;SCINLB;FGF20B;SSH2;RHOA
Insulin signaling pathwayPPARGC1A;IRS4;GYS2;MAPK8;CALML5;MAPK1;FBP1A;SOCS3B;RPS6KB2
Progesterone-mediated oocyte maturationPIK3R3A;ADCY1A;PIK3CA;HSP90AB1;HSP90AA1.2;MAPK12;PRKACAA;MAD2L2;MAPK1
Estrogen signaling pathwayKCNJ6;CREB3L2;CREB5;GABBR1;PIK3CG;CALML5;SHC1;MAP2K1;SRC
Prolactin signaling pathwayNFKB1;SOS1;FOS;SOCS6;SOCS1;PIK3R5;MAPK13;STAT1;SOCS4
Thyroid hormone signaling pathwayATP2A2;ATP1A2;NCOA1;MED1;SLC9A1;MED13;MED17;AKT2;KAT2A
Oxytocin signaling pathwayPPP3R1;PIK3CB;NFATC1;NPR1;PPP3CA;RYR1;GNAI2;NFATC3;ACTB
Regulation of lipolysis in adipocytesPTGER3;PNPLA2;AKT2;INSR;PRKACA;AQP7;NPY;TSHB;FABP4
Type II diabetes mellitusSLC2A4;MTOR;IRS4;HK3;TNF;PIK3R5;IKBKB;MAFA;MAPK3
Insulin resistanceINS2;TNFRSF1A;PRKCD;PPARA;INS1;IKBKB;IRS1;G6PC3;PRKAG1
Non-alcoholic fatty liver disease (NAFLD)PIK3CB;CASP7;INS1;COX7B2;NDUFA10;IL6R;UQCRB;PIK3CG;Il6ra
Aldosterone-regulated sodium reabsorptionATP1B3;ATP1A4;KRAS;IRS1;PIK3R5;PIK3CB;SFN;INSR;KCNJ1
Carbohydrate digestion and absorptionSLC5A1;AKT1;G6PC;PIK3R1;HKDC1;AMY1B;ATP1A3;SLC2A2;SI
Bacterial invasion of epithelial cellsCTNNA1;GAB1;CLTA;CAV2;ILK;ITGB1;PIK3R1;CRKL;RAC1
Chagas disease (American trypanosomiasis)PPP2R2D;CCL2;GNA15;MAPK9;IL12A;IKBKG;PLCB3;FAS;IFNB1
ToxoplasmosisHLA-DRA;BCL2;CD40LG;HLA-DMA;BCL2L1;PIK3R1;LAMC1;IRGM;LAMB4
AmoebiasisMUC2;RAB7B;TGFB3;SERPINB1C;CXCL1;IL6;PIK3R2;SERPINB4;GM-CSF
Hepatitis CSOS1;IFNA7;MAPK13;OAS1A;IFNA12;CLDN18;IFNA13;HRAS;IFNB1
Hepatitis BNFATC4;YWHAB;NFATC1;PCNA;PIK3CB;PRKCB;CCND1;MAVS;CXCL8
MeaslesIFNA13;STAT2;CD209A;EIF2AK1;RAB9A;HSPA8;IFNA21;FYN;IFNA2
Influenza APIK3CA;NUP98;IFNA7;HSPA6;PIK3CG;DNAJB1;PIK3R5;PABPN1;FASLG
HTLV-I infectionATM;ANAPC11;WNT7B;PIK3R2;ITGAL;PCNA;IKBKG;H2-AB1;SLC2A1
Epstein-Barr virus infectionNFKB2;POLR2J;POLR2C;AKAP8L;EP300;HLA-A;POLR2B;CD58;YWHAZ
Pathways in cancerWNT5A;VEGFB;FGFR3;PDGFRA;IL-8;BDKRB2;WNT2B;PLD1;WNT8B
Viral carcinogenesisCDK1;HIST1H4N;GTF2H1;HIST1H2BM;GTF2H2C_2;NFKBIA;IKBKG;HIST1H2BF;PIK3CG
Proteoglycans in cancerPRKCG;CTTN;FZD3;WNT5A;WNT8B;MTOR;PPP1R12A;HGF;PRKACA
Colorectal cancerTGFBR2;MSH6;MAP2K1;GSK3B;RALGDS;AKT2;PIK3CA;ARAF;PIK3CB
Renal cell carcinomaTCEB1;ARNT2;GRB2;RAC1;PIK3R1;SOS1;MAPK1;ETS1;GAB1
Pancreatic cancerERBB2;SMAD3;PIK3CA;PLD1;PIK3R3;RAC3;SMAD4;RAC1;STAT1
Endometrial cancerLEF1;AXIN1;PTEN;PIK3CD;CTNNA3;ERBB2;TRP53;KRAS;PIK3CB
GliomaTGFA;Pdgfa&Pdgfb;KRAS;PLCG2;CALML3;HRAS;PRKCB;TRP53;PIK3CG
Prostate cancerIKBKB;INS2;SPRY1;IGF1;TRP53;CASP9;RAF1;HSP90B1;PDGFD
MelanomaFGF17;FGF9;FGF10;NRAS;FGF5;KRAS;FGF20;FGF2;MAPK3
Chronic myeloid leukemiaSTAT5B;MECOM;CBL;PIK3R3;TGFB2;PIK3R1;NFKB1;HDAC2;BCL2L1
Acute myeloid leukemiaRARA;ZBTB16;RPS6KB2;PIK3CA;RPS6KB1;SPI1;PIK3R2;PIK3CD;MAPK1
Small cell lung cancerRELA;SKP2;TRAF5;APAF1;ITGAV;ITGA2B;PIK3CA;XIAP;LAMA4
Non-small cell lung cancerPRKCA;RASSF5;RXRB;BAD;PIK3CD;BRAF;PIK3CG;NRAS;RB1
Central carbon metabolism in cancerPIK3CG;KRAS;HKDC1;PGAM1;HK2;PKM2;LDHA;NRAS;PDGFRB
Choline metabolism in cancerDGKD;PDGFRA;HIF1A;WASF2;DGKZ;DGKA;SLC22A2;PPAP2A;RAC2

PIK3R1 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity, ErbB-3 class receptor binding, insulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R1 itself. We selected most functions PIK3R1 had, and list some proteins which have the same functions with PIK3R1. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol-3-kinase regulator activityPIK3R6;CCKBR;PIK3R3;PIK3R3B;PIK3R1;PIK3R3A;PIK3R5;PIK3R2
ErbB-3 class receptor bindingPIK3R1;NRG1;CDK5;ERBB2
insulin bindingINSR;PIK3R1;IDE;C2CD2L;HSPD1;IGF1R
insulin receptor bindingSNX1;IRS2;DOK2;FRS2A;DOK1;IGF1R;SNX4;FRS2;DOK1B
insulin receptor substrate bindingPTPN11;JAK2;IGF1R;PRKCD;PRKCZ;INSRA;INSRR;PIK3CB;IGF1RA
insulin-like growth factor receptor bindingIGF3;YWHAG;ARRB1;INSL4;IGF2;SOCS2;INSR;SOCS1;INS
neurotrophin TRKA receptor bindingEFNA5;PIK3R1;GRB2;PLCG1;SHC1;FRS2;NGFR
phosphatidylinositol 3-kinase bindingINSRR;IGF1RA;PIK3R1;FLT3;IRS4;LCK;JAK2;PDGFRB;CALM2
phosphatidylinositol 3-kinase regulator activityAGAP2;PIK3R3B;PIK3R1;KLF4;PIK3R3A
phosphatidylinositol 3-kinase regulatory subunit bindingPTPN13;PIK3AP1;PIK3R1;FAM83A;FAM83B;DNM2;XBP1
protein bindingHIST1H2BE;PSMB9;SUMO3;BLNK;PPP3CA;COMMD3;EXOSC3;CEP76;TNIK
protein heterodimerization activityPBX1;TYRP1;BTBD11A;DLG4B;HIST2H2BE;MYOG;HIST1H2BH;BCL2L1;EGFR
protein phosphatase bindingEIF2AK3;CSF1R;KAT2A;PPP6R3;JAK1;SKAP1;ITPR1;PPARG;HSF4
transcription factor bindingHES4;TWIST1;ESR1;EPAS1;NFATC4;TRIM11;NFATC2;PDCD11;SMAD2
transmembrane receptor protein tyrosine kinase adaptor activityBLNK;DOK2;PIK3R1;FRS2;SHC1;STAP1;TRAT1;IRS1;GAB2

PIK3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R1.

PDGFRB; CBL

Deau, MC; Heurtier, L; et al. A human immunodeficiency caused by mutations in the PIK3R1 gene. JOURNAL OF CLINICAL INVESTIGATION 124:3923-3928(2014).
Sood, A; McClain, D; et al. PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. CLINICAL COLORECTAL CANCER 11:143-150(2012).
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