PINX1
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Official Full Name
PIN2/TERF1 interacting, telomerase inhibitor 1
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Overview
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. -
Synonyms
PINX1; PIN2/TERF1 interacting, telomerase inhibitor 1; PIN2/TERF1-interacting telomerase inhibitor 1; FLJ20565; liver related putative tumor suppressor; LPTL; LPTS; MGC8850; PIN2 interacting protein 1; 67-11-3 protein; Hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; OTTHUMP00000224984; OTTHUMP00000224985; OTTHUMP00000224986; OTTHUMP00000225053; OTTHUMP00000225054; Pin2-interacting protein X1; PINX1_HUMAN; Protein 67-11-3; TRF1-interacting protein 1; PIN2-interacting protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PINX1 involved in several pathways and played different roles in them. We selected most pathways PINX1 participated on our site, such as Regulation of Telomerase, which may be useful for your reference. Also, other proteins which involved in the same pathway with PINX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Telomerase | SP3;PINX1;TNKS;CMTM2A;MXD1;NR2F2;DKC1 |
PINX1 has several biochemical functions, for example, protein binding, telomerase RNA binding, telomerase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PINX1 itself. We selected most functions PINX1 had, and list some proteins which have the same functions with PINX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GABPA;CXXC1;BBS7;EFCAB11;ATP2C2;FAM207A;KPNA1;SRSF11;PAX2 |
| telomerase RNA binding | WRAP53;TERT;PINX1;NHP2;GAR1;HNRNPU;DKC1;NOP10;HNRNPC |
| telomerase inhibitor activity | MCRS1;POT1;POT1A;PINX1 |
PINX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PINX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PINX1.
TERF1; 20475405; TERT; EIF1B; MRPS14; CUTA; SRP72; MT-CO2
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