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PKD1

Official Full Name

polycystic kidney disease 1 (autosomal dominant)
Overview

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.
Synonyms

PKD1; polycystic kidney disease 1 (autosomal dominant); polycystin-1; PBP; Pc 1; polycystin 1; transient receptor potential cation channel; subfamily P; member 1; TRPP1; Autosomal dominant polycystic kidney disease 1 protein; Autosomal dominant polycystic kidney disease protein 1; OTTHUMP00000208669; OTTHUMP00000208670; Pc-1; PKD; PKD1_HUMAN; Polycystic Kidney Disease 1; polycystic kidney disease-associated protein; Polycystin 1 Precursor; transient receptor potential cation channel, subfamily P, member 1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PKD1-4469H	Recombinant Human PKD1 protein, His&His-tagged	E.coli	His&His	25-636aa	Inquiry
Human	PKD1-4470H	Recombinant Human PKD1 protein, His-tagged	E.coli	His	25-636aa	Inquiry
Mouse	PKD1-12857M	Recombinant Mouse PKD1 Protein	Mammalian Cell	His		Inquiry
Mouse	PKD1-6777M	Recombinant Mouse PKD1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PKD1-6777M-B	Recombinant Mouse PKD1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
PKD1 Related Articles

PKD1 involved in several pathways and played different roles in them. We selected most pathways PKD1 participated on our site, such as Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Assembly of the primary cilium	BBS12;IFT74;KIFAP3;KIF3A;B9D2;LZTFL1;BBS1;TTC30A1;TTC26
Cargo trafficking to the periciliary membrane	BBS2;EXOC8;BBS1;BBS10;TTC8;EXOC3;ARF4;PROL1;RP2
Organelle biogenesis and maintenance	ARF4A;CYS1;TUFM;KIFAP3B;TTBK2;TCTEX1D1;TCTEX1D2;MRPL52;DYNLRB1
VxPx cargo-targeting to cilium	PKD1;CNGA5;RAB3IP;PKD2;ARF4A;CNGA2;ARF4
XPodNet - protein-protein interactions in the podocyte expanded by STRING	PKD1;KCP;LIMS2;CDC42EP5;CLNK;MTAP1A;ATP9A;SNTB1;GJB6

PKD1 has several biochemical functions, for example, calcium channel activity, carbohydrate binding, cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD1 itself. We selected most functions PKD1 had, and list some proteins which have the same functions with PKD1. You can find most of the proteins on our site.

Function	Related Protein
calcium channel activity	GPM6A;ITPR1;TRPC3;TRPV3;MCU;TRPC5;CACNA1SB;PKD1;SLC24A1
carbohydrate binding	CLEC7A;POC1BL;PYGM;GALNT9;FCN3;CD55;ATRNL1;LGALS7B;CLEC11A
cation channel activity	TRPV4;FAM26F;GRIN2A;FAM38B;MCOLN1;FAM38A;GRIN3B;ASIC4A;GAR1
ion channel binding	SLC14A2;CIB1;FYN;KCNB1;LYN;FKBP1A;PKP2;AKAP9;PPP1R9B
protein binding	TMEM59;HES1;IRAK1BP1;TMEM199;SESTD1;SOX6;FAM64A;SLC4A4;PFKM
protein domain specific binding	IGBP1;CA;AIDA;PTPN11;SHROOM2;WNT1;NFE2L2;ARRB2;ACTN2
protein kinase binding	GOLGA2;RHOD;ELP2;GPRC5B;TTN;CALM3;SHC3;CCNB3;PTPN23

PKD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD1.

SF1; Pkd2; Id2; ACTB; PDK2; Actb; CTTN

Lian, PW; Li, A; et al. Loss of Polycystin-1 Inhibits Bicc1 Expression during Mouse Development. PLOS ONE 9:-(2014).

Vijayakumar, S; Dang, S; et al. Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 306:F640-F654(2014).