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PKD2L1

Official Full Name

polycystic kidney disease 2-like 1
Overview

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane;domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in;cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two;transcript variants encoding different isoforms have been found for this gene.
Synonyms

PKD2L1; polycystic kidney disease 2-like 1; PKD2L, PKDL; polycystic kidney disease 2-like 1 protein; PCL; transient receptor potential cation channel; subfamily P; member 3; TRPP3; B830002B15; BC046386; PK2L1; PK2L1_HUMAN; PKD2L; PKDL; Polycystic kidney disease 2 like 1 protein; Polycystin L; Polycystin-2 homolog; Polycystin-2L1; Polycystin-L; Polycystin-L1; transient receptor potential cation channel, subfamily P, member 3;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PKD2L1-1739H	Recombinant Human PKD2L1, GST-tagged	E.coli	GST	C-term-245aa	$319 / 25ug
Human	PKD2L1-1185HFL	Recombinant Human PKD2L1 protein, His&Flag-tagged	HEK293	His&Flag	1-758 aa	Inquiry
Mouse	PKD2L1-12861M	Recombinant Mouse PKD2L1 Protein	Mammalian Cell	His		Inquiry
Mouse	PKD2L1-6780M	Recombinant Mouse PKD2L1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PKD2L1-6780M-B	Recombinant Mouse PKD2L1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

PKD2L1 involved in several pathways and played different roles in them. We selected most pathways PKD2L1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PKD2L1 has several biochemical functions, for example, alpha-actinin binding, calcium activated cation channel activity, calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD2L1 itself. We selected most functions PKD2L1 had, and list some proteins which have the same functions with PKD2L1. You can find most of the proteins on our site.

Function	Related Protein
alpha-actinin binding	PKD2L1;ADORA2A;LRRC10;MYOT;RARA;MAGI1;DAG1;KCNN2;KCNA5
calcium activated cation channel activity	ANO10;CALHM1;CATSPER1;TRPM5;TRPM4A;TRPM4;CATSPER2;ANO6;PKD2L1
calcium channel activity	TRPC7A;CACNG7A;AKR1C1;TRPC1;PKD2L2;SLC24A1;UBXN6;SLC24A4A;TRPV1
calcium ion binding	ASPH;PCDH2AB10;S100U;DGKB;UBE4A;PCDHB11;FSTL1B;CETN4;RHOT2
calcium-activated potassium channel activity	MTMR6;KCNMB1;KCNN1A;HPN;KCNMB2;KCNN4;CCT8L2;KCNMB3;PKD2L1
cation channel activity	FAM38A;FAM26F;TRPV2;CALHM3;ASIC1C;GRIN2C;PKD1;TRPV4;FAM26E
contributes_to cation transmembrane transporter activity	PKD2L1;PKD1L3
cytoskeletal protein binding	PDLIM3;PTPN4;PKD2;RPH3AL;EPB41L3A;EPB41L4B;FRMD5;MSNA;EPB41L3B
identical protein binding	TRADD;TTN;TRP53;AGXT2L2;VAMP2;SH3GL1;UGP2;P2RX6;ZBTB16
muscle alpha-actinin binding	NRAP;MYPN;PALLD;PDLIM2;PKD2L1;PKD2;LDB3;TTN
protein binding	PDGFRA;OSTF1;LZTS2;SERPINA5;NETO2;GEMIN4;HIST1H2AG;RGS7BP;LY6H
sodium channel activity	SCN8AA;ASIC1B;KCNK1;SCN11A;TRPM5;ASIC1C;SLC4A11;SCN12AB;ASIC4
contributes_to sour taste receptor activity	PKD1L3;PKD2L1

PKD2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD2L1.

PKD1L3