PLA2G12A
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Official Full Name
phospholipase A2, group XIIA
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Overview
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids;and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low;specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 (PubMed;11031251)). -
Synonyms
PLA2G12A; phospholipase A2, group XIIA; phospholipase A2, group XII , PLA2G12; group XIIA secretory phospholipase A2; EC 3.1.1.4; Group XIIA secretory phospholipase A2 precursor; GXII sPLA2; Phosphatidylcholine 2 acylhydrolase GXII; Phospholipase A2 group XIIA; PLA2G12; sPLA2-XII; group XII secreted phospholipase A2; group XIIA secreted phospholipase A2; phosphatidylcholine 2-acylhydrolase 12A; GXII; ROSSY;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- His|T7
- SUMO
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PLA2G12A Related Articles
PLA2G12A involved in several pathways and played different roles in them. We selected most pathways PLA2G12A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycerophospholipid metabolism | LPIN2;CDS1;PCYT1BB;ETNPPL;ETNK2;ADPRM;PCYT1AB;PPAP2A;LCLAT1 |
Ether lipid metabolism | PLD4;PLA2G4C;GAL3ST1;PLB1;PPAP2A;PLD1;PLA2G2D;PLA2G4AA;UGT8 |
Arachidonic acid metabolism | CYP2C55;PTGDSB;CYP2J6;CYP2N13;AKR1C3;CYP1A2;CYP2AD3;FAAH2B;ALOX12 |
Linoleic acid metabolism | CYP2P6;CYP2J5;PLA2G6;ALOX15;CYP3A25;PLA2G5;PLA2G4D;CYP2C55;DHRS13L1 |
alpha-Linolenic acid metabolism | PLA2G6;PLA2G2A;PLA2G2F;PLA2G4A;PLA2G4AA;PLA2G4F;PLA2G5;PLA2G4D;PLA2G2E |
Metabolic pathways | ENPP7;AGPAT5;MBOAT2;ACSL4;ALPI.1;PDXK;CYP7A1;PKM2;GBA2 |
Ras signaling pathway | PLA2G12B;FGF11;RASAL3;PIK3CA;MAPK9;HTR7;INS;RAF1;FGFR2 |
Vascular smooth muscle contraction | PLA2G4D;EDNRAA;KCNMB2;PLA2G2E;GNA12;PPP1CAB;KCNMB4;PLA2G3;AVPR1A |
Pancreatic secretion | PLA2G2A;SLC26A3;CPB2;RAB11A;CLCA5;PLA2G10;ATP2B1;SCTR;ATP1B2 |
Fat digestion and absorption | FABP1;SCARB1;PLA2G10;MOGAT2;PLA2G2A;PLA2G5;CLPS;PLA2G2E;DGAT1 |
PLA2G12A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G12A itself. We selected most functions PLA2G12A had, and list some proteins which have the same functions with PLA2G12A. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | PLA2G12A;PVALB9;EGFL6;CAPN2A;MCTP2;EHD1B;FREM2B;PCDH2G9;EFCAB10 |
calcium-dependent phospholipase A2 activity | PLA2G4F;PLA2G2A;PLA2G1B;PLA2G4B;PLA2G3;PLA2G5;PLA2G12A;PLA2G4A |
PLA2G12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G12A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G12A.
DVL2; RB1; UMPS; YWHAG; RPS6; RPS15; MEF2C; TMEM37; UCK1; EPB41L3
- Q&As
- Reviews
Q&As (5)
Ask a questionPLA2G12A-generated lipid mediators can act as signaling molecules, influencing various cellular processes and pathways.
Investigations are underway to explore the role of PLA2G12A in cancer progression, with the goal of identifying therapeutic strategies to target this protein.
PLA2G12A is involved in the generation of lipid mediators, such as eicosanoids, which play a role in inflammation and immune responses.
Studies suggest that alterations in PLA2G12A expression or activity may serve as potential diagnostic markers for certain diseases, although more research is needed.
Information on current clinical trials targeting PLA2G12A can be obtained from databases like ClinicalTrials.gov, indicating the evolving interest in its therapeutic potential.
Customer Reviews (3)
Write a reviewthe manufacturer of the PLA2G12A protein plays a vital role in supporting my research endeavors.
the manufacturer's commitment to ongoing innovation ensures that I have access to the most advanced and updated versions of the PLA2G12A protein.
They proactively monitor scientific advancements and customer feedback to continually refine and improve the performance of the protein.
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