PLA2G1B
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Official Full Name
phospholipase A2, group IB (pancreas)
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Overview
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known;varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2;enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to;venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine,;macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986;(PubMed 3028739)) . -
Synonyms
PLA2G1B; phospholipase A2, group IB (pancreas); PLA2, PLA2A, PPLA2; phospholipase A2; group IB phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B; PLA2; PLA2A; PPLA2; MGC119834; MGC119835;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human Cell
- Mammalian Cell
- Mammalian cells
- C
- His
- Myc
- DDK
- His (Fc)
- Avi
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PLA2G1B Related Articles
- PLA2G1B Related Research Area
PLA2G1B involved in several pathways and played different roles in them. We selected most pathways PLA2G1B participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycerophospholipid metabolism | PNPLA7;PLD1;CHATA;PCYT1AA;CHKA;DGKZ;PLA2G2E;PMT;PLA2G4AA |
Ether lipid metabolism | PLB1;PLA2G3;UGT8A;PLA2G2A;PAFAH1B1;PAFAH1B3;CEPT1B;GAL3ST1;CEPT1 |
Arachidonic acid metabolism | DPEP2;CYP2C8;FAAH2;PLA2G4AA;PTGIS;CYP2C19;AKR1C3;LTA4H;CYP1B1 |
Linoleic acid metabolism | PLA2G6;CYP2C39;CYP2P9;CYP3A41B;PLA2G5;PLA2G4D;CYP2J5;PLA2G10;PLA2G12A |
alpha-Linolenic acid metabolism | ACOX1;PLA2G5;PLA2G2E;PLA2G4AA;PLA2G6;PLA2G2F;PLA2G3;PLA2G2A;PLA2G1B |
Metabolic pathways | HYAL4;INPP1;NFS1;POLR2J;PIK3C3;CYP17A1;PGAM2;CYP2A4;GLULC |
Ras signaling pathway | FGF2;RASGRF2;SHC4;GNB1;PLA2G4A;GNB4;PLD1;GNG10;BCL2L1 |
Vascular smooth muscle contraction | ARHGEF1;PLA2G2D;PRKACBA;GNA12A;ADORA2AA;CACNA1SA;RHOA;ROCK2A;CALM1A |
Pancreatic secretion | ITPR3;ATP2B1;AMY2B;ATP1A2;PLCB4;PLCB2;CPA1;PLA2G12B;CELA2B |
Fat digestion and absorption | MOGAT3;AGPAT2;PPAP2A;DGAT1;CLPS;Cel;ABCG8;PNLIPRP2;ACAT2 |
PLA2G1B has several biochemical functions, for example, bile acid binding, calcium ion binding, calcium-dependent phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G1B itself. We selected most functions PLA2G1B had, and list some proteins which have the same functions with PLA2G1B. You can find most of the proteins on our site.
Function | Related Protein |
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bile acid binding | NR1H4;FABP6;STARD5;AKR1C2;PLA2G1B;FABP10A;AKR1C21;FABP1;PYGL |
calcium ion binding | SLC25A23;NOTCH1B;FBLN2;MGP;CAPNS1B;BGLAP;EFCAB4A;PVALB7;CALB2 |
calcium-dependent phospholipase A2 activity | PLA2G1B;PLA2G3;PLA2G12A;PLA2G2A;PLA2G4F;PLA2G5;PLA2G4A;PLA2G4B |
phospholipase A2 activity | PLA2G2D;PLA2G10;PLA2G2F;PLB1;PLA2G12B;PNPLA3;PLA2G4D;RARRES3;PLA2G4A |
receptor binding | CSK;CAPRIN2;FGF12A;ECH1;FGF18A;TNFSF9;APOF;FGF6A;POU2F1 |
PLA2G1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G1B.
SOCS2
- Q&As
- Reviews
Q&As (5)
Ask a questionPLA2G1B is associated with atherosclerosis and other cardiovascular conditions due to its involvement in lipid metabolism and inflammation.
Modulating PLA2G1B activity could be explored for potential neuroprotective effects, given its involvement in processes related to neuroinflammation.
Dysregulation of PLA2G1B has been linked to inflammatory disorders, cardiovascular diseases, and certain cancers.
Yes, targeting PLA2G1B may be a potential therapeutic strategy for inflammatory diseases, as it plays a role in the production of inflammatory mediators.
Inhibiting PLA2G1B may be explored as a therapeutic approach in cancer treatment by disrupting lipid metabolism and inhibiting cancer cell proliferation.
Customer Reviews (3)
Write a reviewIts exceptional purity and stability make it an ideal choice for a wide range of applications, ensuring reliable and reproducible results.
The PLA2G1B protein comes highly recommended for its exceptional performance in various research applications.
Its unique characteristics contribute to obtaining clear and detailed structural information, allowing researchers to gain insights into protein interactions and conformational changes.
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