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PLAGL1

Official Full Name

pleiomorphic adenoma gene-like 1
Overview

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5 UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010]
Synonyms

PLAGL1; pleiomorphic adenoma gene-like 1; ZAC; LOT1; ZAC1; zinc finger protein PLAGL1; LOT-1; PLAG-like 1; tumor supressor ZAC; tumor suppressor ZAC; lost on transformation 1; pleiomorphic adenoma-like protein 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

His
HIS
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PLAGL1-069H	Recombinant Human PLAGL1 Protein, HIS-tagged	E.coli	HIS		Inquiry
Human	PLAGL1-31027TH	Recombinant Human PLAGL1	Wheat Germ	N/A	100 amino acids	Inquiry
Human	PLAGL1-3133HCL	Recombinant Human PLAGL1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PLAGL1-752H	Recombinant Human PLAGL1 Protein, His-tagged	E.coli	His	His226~Pro362	$298 / 10ug
Human	PLAGL1-3585H	Recombinant Human PLAGL1 protein, His-tagged	E.coli	His	201-463 aa	$319 / 25ug
Mouse	Plagl1-1946M	Recombinant Mouse Plagl1 Protein, His-tagged	E.coli	N-His	Phe4-Met212	Inquiry
Rat	Plagl1-1947R	Recombinant Rat Plagl1 Protein, His-tagged	E.coli	N-His	Phe4-Met212	Inquiry
Rhesus Macaque	PLAGL1-3460R	Recombinant Rhesus monkey PLAGL1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	PLAGL1-3278R	Recombinant Rhesus Macaque PLAGL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	PLAGL1-3278R-B	Recombinant Rhesus Macaque PLAGL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

PLAGL1 involved in several pathways and played different roles in them. We selected most pathways PLAGL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAGL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PLAGL1 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAGL1 itself. We selected most functions PLAGL1 had, and list some proteins which have the same functions with PLAGL1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	FOXG1D;ZNF80;NACA;ZNF559;ZFP687;DEDD2;SOS1;OTX1A;VENT
RNA polymerase II regulatory region sequence-specific DNA binding	AEBP1;ESX1;BARHL2;BHLHA15;POU3F4;TRPS1;GATA2;HES6;HOXD8
RNA polymerase II transcription factor activity, sequence-specific DNA binding	TP73;NHLH2;EPAS1B;HOXA13A;GATA6;SP1;ATF4;FOXI3B;FOXJ3
metal ion binding	EXTL2;GTF3AA;B4GALT2;ACSM4;NOX1;ZBTB42;ZFP131;TIMM8B;NOTCH1A
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	ZGLP1;STAG1;NKX2;SOX17;BARX2;DLX2;NR1I2;GATA1A;FOXC1

PLAGL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAGL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAGL1.

SMAD3