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PLEC

Official Full Name

plectin
Overview

Plectin interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the crosslinking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
Synonyms

PLEC1; Plectin-1; Hemidesmosomal protein 1; plectin; PLTN; PCN; plectin 1, intermediate filament binding protein 500kDa; HD1; EBS1; epidermolysis bullosa simplex 1 (Ogna); plectin 1, intermediate filament binding protein, 500kD; EBSO; PLEC1b; LGMD2Q; OTTHUMP00000229282; OTTHUMP00000229283; OTTHUMP00000229284; OTTHUMP00000229285; OTTHUMP00000229286; OTTHUMP00000229287; OTTHUMP00000229288; PLEC;

Type

Recombinant Proteins

Species

Human

Source

E.coli
HEK293
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PLEC1-32H	Recombinant Human PLEC Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	PLEC-32H	Recombinant Human PLEC Protein, GST-tagged	Wheat Germ	GST	4384 a.a. - 4493 a.a.	Inquiry
Human	PLEC-30873TH	Recombinant Human PLEC, His-tagged	E.coli	His		Inquiry
Human	PLEC-1357H	Recombinant Human PLEC Protein, His-tagged	E.coli	His		Inquiry
Human	PLEC-1877H	Recombinant Human PLEC protein, His-tagged	HEK293	His	Ala 4377 - Ala 4684	Inquiry
Human	PLEC-1837H	Recombinant Human PLEC protein, GST-tagged	E.coli	GST	1475-1768 aa	$319 / 25ug

Involved Pathway
Protein Function
Interacting Protein

PLEC involved in several pathways and played different roles in them. We selected most pathways PLEC participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Apoptosis, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLEC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Alpha6-Beta4 Integrin Signaling Pathway	COL17A1;DSP;YWHAQ;EIF4EB;DST;EGFR;CD151L;RTKN;EIF4E
Apoptosis	PANK1A;GZMF;NMT1;STK26;AKT1;DFFA;BCL2A;CASP6L1;TNFRSFA
Apoptotic cleavage of cellular proteins	DBNLA;VIML;DSG1;DBNL;DSG2;SPNA2;SATB1;CTNNB2;CASP8L1
Apoptotic execution phase	GAS2;HIST1H1C;OCLN;PTBP3;HIST1H1E;DBNLA;PANK1A;HMGB2;CTNNB1
Assembly of collagen fibrils and other multimeric structures	ABHD1;COL1A2;DST;COL6A1;TLL1;MMP20;COL1A1;LOX;TLL2
Caspase-mediated cleavage of cytoskeletal proteins	CASP6L2;PLEC;VIML;PLECA;GAS2;ADD1;DBNLB;DBNL;DBNLA
Cell junction organization	CLDN23;INADL;ANG;PARVB;CDH3;CDH12;CDH11;CDH10A;RSU1
Cell-Cell communication	COL17A1;CDH13;SIRPA;DSCAML1;SKAP2;CLDN23;CDH9;PARVB;PVRL2L

PLEC has several biochemical functions, for example, actin binding, ankyrin binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLEC itself. We selected most functions PLEC had, and list some proteins which have the same functions with PLEC. You can find most of the proteins on our site.

Function	Related Protein
actin binding	MYH4;ANLN;FSCN2;EPS8;GMFG;GSN;CNN1;LRRC10;DIAPH3
ankyrin binding	PLEC;KCNQ2;KCNJ11;SCN5A;NRCAM;RHBG;OBSCN;PTBP3;SLC8A1
poly(A) RNA binding	MTO1;WDR3;HNRNPF;RRP12;AGO3;CCBL2;EEF1A1;RPL27A;CCAR1
protein binding	NCOA2;UBL7;ITGA6;CCDC42;ABCE1;SPG20;PITX1;SLC6A4;EIF4G1
structural constituent of muscle	MYBPC3;MYBPC2;MYL5;ASPH;TCAP;MYL6;SORBS2;COX4I2;ANKRD2

PLEC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLEC here. Most of them are supplied by our site. Hope this information will be useful for your research of PLEC.

ITGB4; FUS; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; EWSR1; SQSTM1; TSC22D1; PAN2; KCTD13; TAF15; USP20