PMAIP1
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Official Full Name
phorbol-12-myristate-13-acetate-induced protein 1
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Overview
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. -
Synonyms
PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1; APR; NOXA; protein Noxa; PMA-induced protein 1; immediate-early-response protein APR; adult T cell leukemia-derived PMA-responsive;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PMAIP1 involved in several pathways and played different roles in them. We selected most pathways PMAIP1 participated on our site, such as p signaling pathway, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMAIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p signaling pathway | SERPINE1;RPRMA;ATM;BAX;TP53AIP1;CYCS;THBS1;PTEN;SESN2 |
| Viral carcinogenesis | NFKB2;H2-Q10;CREB3L3;HIST1H4K;HDAC7;GTF2E1;HIST2H2BB;BAX;HLA-G |
PMAIP1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PMAIP1 itself. We selected most functions PMAIP1 had, and list some proteins which have the same functions with PMAIP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PTPN1;THG1L;METTL1;CCBE1;RAET1D;TCEB3B;MRPL51;ASGR1;ATF2 |
PMAIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMAIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PMAIP1.
MCL1; BCL2L1; BCL2L2; BCL2; BCL2; Mcl1; Bcl2a1; BCL2L11; f1_vaccp
- Q&As
- Reviews
Customer Reviews (3)
Write a reviewManufacturers can support researchers in developing assays to measure PMAIP1 protein levels or activity specific to their clinical trial settings.
They can offer detailed characterization data, including purity, stability, and functional assessments, to support researchers' confidence in using the protein in their trials.
This may involve guidance in selecting appropriate detection methods, providing assay components, or optimizing protocols for optimal performance and sensitivity.
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