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PMCH

Official Full Name

pro-melanin-concentrating hormone
Overview

The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and;later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona;incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic;distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions;directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other;putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in;many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) (summary;by Nahon et al., 1992 (PubMed 1572663)).
Synonyms

PMCH; pro-melanin-concentrating hormone; pro-MCH; MCH; melanin-concentrating hormone;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PMCH-172H	Recombinant Human PMCH, His-tagged	HEK293	His	Inquiry
Human	PMCH-646H	Recombinant Human PMCH Protein, His-tagged	E.coli	His	Inquiry
Human	PMCH-488HCL	Recombinant Human PMCH lysate	HEK293	N/A	Inquiry
Human	PMCH-2149H	Recombinant Human PMCH Protein, His-tagged	E.coli	His	Inquiry
Rat	PMCH-4540R	Recombinant Rat PMCH Protein	Mammalian Cell	His	Inquiry
Rat	PMCH-4200R	Recombinant Rat PMCH Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	PMCH-4200R-B	Recombinant Rat PMCH Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	PMCH-8000Z	Recombinant Zebrafish PMCH	Mammalian Cell	His	Inquiry
Chicken	PMCH-4155C	Recombinant Chicken PMCH	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PMCH Related Articles

PMCH involved in several pathways and played different roles in them. We selected most pathways PMCH participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMCH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)	EDN1;CNR2;PMCH;EDNRAB;NMU;DRD2;CXCR7B;S1PR5B;APLNR
G alpha (i) signalling events	GAL;ADRA2A;OPN1LW2;S1PR5B;ADORA3;RGS20;LPAR5A;RGS21;ANXA1
G alpha (q) signalling events	HCRT;FPR-RS4;CCK;QRFP;GCGB;GCGA;LTB4R;AGT;UTS2D
GPCR downstream signaling	CALCRL;CCR1;ARHGEF1B;ITSN1;ANXA1;RGS20;PROK1;AKAP13;CCK
GPCR ligand binding	GPR132B;AGT;EMR3;FPR-RS3;DRD4;EDNRAB;PYY;HEBP1;CNR2
Gastrin-CREB signalling pathway via PKC and MAPK	KISS1;TAC3;TRH;TRPC7;QRFP;FPR-RS6;FPR-RS3;LPAR2B;CASR
Peptide ligand-binding receptors	RLN3;NPB;PROKR2;SST;UTS2;INSL5;XK;UTS2D;PENKA
Signal Transduction	KIF7;ARHGAP8;ARHGAP29;WDR19;ZFPM2B;SOX32;GPR31B;ARHGAP11A;RGS10

PMCH has several biochemical functions, for example, melanin-concentrating hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PMCH itself. We selected most functions PMCH had, and list some proteins which have the same functions with PMCH. You can find most of the proteins on our site.

Function	Related Protein
melanin-concentrating hormone activity	PMCH;PMCHL

PMCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMCH here. Most of them are supplied by our site. Hope this information will be useful for your research of PMCH.

Tuziak, SM; Rise, ML; et al. An investigation of appetite-related peptide transcript expression in Atlantic cod (Gadus morhua) brain following a Camelina sativa meal-supplemented feeding trial. GENE 550:253-263(2014).

Walter, LJ; Gasch, CA; et al. Association of pro-melanin concentrating hormone genotype with beef carcass quality and yield. JOURNAL OF ANIMAL SCIENCE 92:325-331(2014).