PNPLA6
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Official Full Name
patatin-like phospholipase domain containing 6
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Overview
This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PNPLA6; patatin-like phospholipase domain containing 6; neuropathy target esterase; NTE; sws; EC 3.1.1.5; NTEMND; Patatin like phospholipase domain containing 6; Patatin like phospholipase domain containing protein 6; Patatin-like phospholipase domain-containing protein 6; PLPL6_HUMAN; SPG39;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PNPLA6-1819H | Recombinant Human PNPLA6, His-tagged | E.coli | His | 977-1327aa | |
| Human | PNPLA6-29926TH | Recombinant Human PNPLA6, His-tagged | E.coli | His |
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| Human | PNPLA6-1726H-B | Recombinant Human PNPLA6 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Human | PNPLA6-920HFL | Recombinant Full Length Human PNPLA6 Protein, C-Flag-tagged | Mammalian cells | Flag |
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| Human | PNPLA6-1726H | Recombinant Human PNPLA6 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | PNPLA6-2408H | Recombinant Human PNPLA6 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Mouse | PNPLA6-13045M | Recombinant Mouse PNPLA6 Protein | Mammalian Cell | His |
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| Mouse | Pnpla6-4973M | Recombinant Mouse Pnpla6 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Mouse | PNPLA6-6890M | Recombinant Mouse PNPLA6 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | PNPLA6-6890M-B | Recombinant Mouse PNPLA6 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | PNPLA6-3804C | Recombinant Chicken PNPLA6 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- PNPLA6 Related Articles
PNPLA6 involved in several pathways and played different roles in them. We selected most pathways PNPLA6 participated on our site, such as Glycerophospholipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | PMT;LCAT;GPAM;PLA2G1B;PCYT1AB;PLD1;PTDSS1A;PLA2G4A;PCYT1AA |
PNPLA6 has several biochemical functions, for example, lysophospholipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA6 itself. We selected most functions PNPLA6 had, and list some proteins which have the same functions with PNPLA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lysophospholipase activity | PNPLA6;LGALS13;Cel;ASPG;LYPLA1;PLA2G4A;PNPLA7A;ENPP2;PNPLA7 |
PNPLA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA6.
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- Q&As
- Reviews
Q&As (6)
Ask a questionMolecular biology and biochemical methods, such as yeast two-hybridization, affinity chromatography, mass spectrometry, etc., can be used to study the interaction network of PNPLA6. These methods can help us understand the function and mechanism of action of PNPLA6 in cells.
The interaction of PNPLA6 with other proteins or molecules is not fully understood. However, based on its structural and functional characteristics, it can be speculated that it may interact with some enzymes, transcription factors, or other signal transduction molecules to participate in lipid metabolism and cell signaling processes.
Cell models with PNPLA6 overexpression or knockout can be established by gene transfection. The vector of the gene of interest or a specific knockout gene is introduced into the cells, and the stably expressed or knocked out cell line is obtained through screening and identification.
Mutations in PNPLA6 may have a variety of effects on cells, such as affecting lipid metabolism, causing abnormal cell proliferation, and inducing apoptosis. These effects may be related to the occurrence of some diseases, such as neurological diseases, metabolic diseases, etc.
PNPLA6 can be used as a biomarker for disease diagnosis and as a therapeutic target. For example, inhibitors targeting PNPLA6 can be used to treat certain disorders associated with abnormal lipid metabolism, while overexpression may be associated with certain neurological disorders.
The expression regulation mechanism of PNPLA6 involves multiple levels, including transcriptional level, post-transcriptional level, translation level and post-translational level. These regulatory mechanisms work together to ensure that the expression level of PNPLA6 in cells remains stable.
Customer Reviews (3)
Write a reviewThey have a wide range of products to meet our needs in different fields of study.
It is not easy to inactivate, and it is still active after trying a variety of experimental conditions.
The sensitivity is extremely high, the experimental results are very good, and unnecessary troubles are reduced.
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